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Lavanya M Iyer
Genome Institute of Singapore
CardiologyKLF15TCF7L2BiologyCell biology
9Publications
2H-index
10Citations
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Publications 10
Newest
#1Eric Schoger (GAU: University of Göttingen)H-Index: 1
#2Kelli J. Carroll (UTSW: University of Texas Southwestern Medical Center)H-Index: 2
Last. Laura C Zelarayan (GAU: University of Göttingen)H-Index: 5
view all 15 authors...
Rationale: Genome editing by CRISPR/Cas9 is evolving rapidly. Recently, second generation CRISPR/Cas9 activation systems based on nuclease inactive "dead" (d)Cas9 fused to transcriptional transacti...
Source
#1Claudia Noack (Bayer)H-Index: 1
#2Lavanya M Iyer (Genome Institute of Singapore)H-Index: 2
Last. Laura C Zelarayan (GAU: University of Göttingen)H-Index: 5
view all 14 authors...
Abstract Background The combination of cardiomyocyte (CM) and vascular cell (VC) fetal reprogramming upon stress culminates in end-stage heart failure (HF) by mechanisms that are not fully understood. Previous studies suggest KLF15 as a key regulator of CM hypertrophy. Objectives This study aimed to characterize the impact of KLF15-dependent cardiac transcriptional networks leading to HF progression, amenable to therapeutic intervention in the adult heart. Methods Transcriptomic bioinformatics, ...
2 CitationsSource
#1Eric Schoger (GAU: University of Göttingen)H-Index: 1
#2Kelli J. Carroll (UTSW: University of Texas Southwestern Medical Center)H-Index: 2
Last. Laura C Zelarayan (GAU: University of Göttingen)H-Index: 5
view all 10 authors...
Source
#1Claudia Noack (GAU: University of Göttingen)H-Index: 4
#1Claudia Noack (GAU: University of Göttingen)H-Index: 4
Last. Laura C Zelarayan (GAU: University of Göttingen)H-Index: 5
view all 9 authors...
Source
#1Susanne F. Schlick (GAU: University of Göttingen)H-Index: 2
#2Florian Spreckelsen (MPG: Max Planck Society)H-Index: 2
Last. Florian Rehfeldt (GAU: University of Göttingen)H-Index: 19
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Abstract Cardiomyocyte and stroma cell cross-talk is essential for the formation of collagen-based engineered heart muscle, including engineered human myocardium (EHM). Fibroblasts are a main component of the myocardial stroma. We hypothesize that fibroblasts, by compacting the surrounding collagen network, support the self-organization of cardiomyocytes into a functional syncytium. With a focus on early self-organization processes in EHM, we studied the molecular and biophysical adaptations med...
2 CitationsSource
Source
#1Lavanya M Iyer (GAU: University of Göttingen)H-Index: 2
#2Sankari Nagarajan (GAU: University of Göttingen)H-Index: 9
Last. Laura C Zelarayan (GAU: University of Göttingen)H-Index: 5
view all 17 authors...
7 CitationsSource
#2Sara KhadjehH-Index: 7
Last. Laura C. ZelarayánH-Index: 5
view all 7 authors...
Introduction: Available pharmacological treatments for cardiovascular diseases (CVD) delay, but do not prevent the onset of heart failure (HF). To succeed with novel interventions preventing HF, it...
#1Lavanya M IyerH-Index: 2
#2Claudia NoackH-Index: 4
Last. Laura C ZelarayanH-Index: 5
view all 12 authors...
Source
#1Claudia NoackH-Index: 4
#2Lavanya M IyerH-Index: 2
Last. Laura C. ZelarayánH-Index: 5
view all 5 authors...
Background & Aim: Developmentally conserved pathways, such as the Wnt/β-catenin pathway, are upregulated in adult heart diseases. Here, we aimed to elucidate the role of Wnt regulation via KLF15 for adult heart homeostasis. Results: We identified the transcription factor KLF15, a factor previously identified to contribute to cardiac fibrosis and hypertrophy, as a cardiac specific Wnt/β-catenin inhibitor. Accordingly, a constitutive Klf15 KO mouse model revealed specific cardiac upregulation of t...
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