Kai Schönig
Heidelberg University
TransgeneGenetically modified mouseMolecular biologyNeuroscienceBiology
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Publications 71
#1Praveen K. Dhandapani (UH: University of Helsinki)H-Index: 3
#2Isabel M. Begines-Moreno (Pablo de Olavide University)H-Index: 1
Last. Marten Szibor (UH: University of Helsinki)H-Index: 14
view all 13 authors...
Constitutive expression of the chemokine Mcp1 in mouse cardiomyocytes creates a model of inflammatory cardiomyopathy, with death from heart failure at age 7–8 months. A critical pathogenic role has previously been proposed for induced oxidative stress, involving NADPH oxidase activation. To test this idea, we exposed the mice to elevated oxygen levels. Against expectation, this prevented, rather than accelerated, the ultrastructural and functional signs of heart failure. This result suggests tha...
1 CitationsSource
#1Peter Wirthschaft (DKFZ: German Cancer Research Center)H-Index: 1
#2Julia Bode (DKFZ: German Cancer Research Center)H-Index: 6
Last. Björn Tews (DKFZ: German Cancer Research Center)H-Index: 9
view all 23 authors...
Glioblastomas strongly invade the brain by infiltrating into the white matter along myelinated nerve fiber tracts even though the myelin protein Nogo-A prevents cell migration by activating inhibitory RhoA signaling. The mechanisms behind this long-known phenomenon remained elusive so far, precluding a targeted therapeutic intervention. This study demonstrates that the prevalent activation of AKT in gliomas increases the ER protein-folding capacity and enables tumor cells to utilize a side effec...
#1Hamid R. NooriH-Index: 15
#2Christian Mücksch (TUK: Kaiserslautern University of Technology)H-Index: 7
Last. Steven M. Sine (Mayo Clinic)H-Index: 58
view all 13 authors...
Alcohol consumption affects many organs and tissues, including skeletal muscle. However, the molecular mechanism of ethanol action on skeletal muscle remains unclear. Here, using molecular dynamics simulations and single channel recordings, we show that ethanol interacts with a negatively charged amino acid within an extracellular region of the neuromuscular nicotinic acetylcholine receptor (nAChR), thereby altering its global conformation and reducing the single channel current amplitude. Charg...
#1Laura Broccoli (Heidelberg University)H-Index: 5
#2Stefanie Uhrig (Heidelberg University)H-Index: 7
Last. Anita C. Hansson (Heidelberg University)H-Index: 23
view all 10 authors...
Rationale The corticotropin-releasing hormone (CRH) system is a key mediator of stress-induced responses in alcohol-seeking behavior. Recent research has identified the central nucleus of the amygdala (CeA), a brain region involved in the regulation of fear and stress-induced responses that is especially rich in CRH-positive neurons, as a key player in mediating excessive alcohol seeking. However, detailed characterization of the specific influences that local neuronal populations exert in media...
5 CitationsSource
#1Olena MolokanovaH-Index: 7
#2Kai SchönigH-Index: 22
Last. Steffen LorenzH-Index: 7
view all 10 authors...
#1Bianca Völkening (Heidelberg University)H-Index: 1
#2Kai Schönig (Heidelberg University)H-Index: 22
Last. Tillmann Weber (Heidelberg University)H-Index: 10
view all 5 authors...
In the central nervous system, CaV1.2 and CaV1.3 constitute the main L-type voltage-gated calcium channels (LTCCs) coupling membrane depolarization to gene transcription. We have previously demonstrated that inducible disruption of Cav1.2 in type-1 astrocyte-like stem cells of the adult dentate gyrus (DG) impairs hippocampal neurogenesis in a cell-autonomous fashion. To address the role of Cav1.3 channels (encoded by the Cacna1d gene), we here generated TgGLAST-CreERT2/Cacna1dfl/fl/RCE:loxP mice...
#1Stefan Berger (Heidelberg University)H-Index: 32
#2Iván Fernández-Lamo (Pablo de Olavide University)H-Index: 6
Last. Dusan Bartsch (Heidelberg University)H-Index: 30
view all 15 authors...
Dendritic messenger RNA (mRNA) localization and subsequent local translation in dendrites critically contributes to synaptic plasticity and learning and memory. Little is known, however, about the contribution of RNA-binding proteins (RBPs) to these processes in vivo. To delineate the role of the double-stranded RBP Staufen2 (Stau2), we generate a transgenic rat model, in which Stau2 expression is conditionally silenced by Cre-inducible expression of a microRNA (miRNA) targeting Stau2 mRNA in ad...
7 CitationsSource
#1Olena Molokanova (University of Mainz)H-Index: 7
#2Kai Schönig (Heidelberg University)H-Index: 22
Last. Detlef Schuppan (University of Mainz)H-Index: 63
view all 12 authors...
• Fibrosis is characterized by excess deposition of extracellular matrix components, especially collagen type I.
7 CitationsSource
#1Miriam Schneider (Heidelberg University)H-Index: 26
#2Petrus J. de Vries (UCT: University of Cape Town)H-Index: 17
Last. Robert Waltereit (TUD: Dresden University of Technology)H-Index: 12
view all 5 authors...
Epilepsy is a major risk factor for autism spectrum disorder (ASD) and complicates clinical manifestations and management of ASD significantly. Tuberous sclerosis complex (TSC), caused by TSC1 or TSC2 mutations, is one of the medical conditions most commonly associated with ASD and has become an important model to examine molecular pathways associated with ASD. Previous research showed reversal of autism-like social deficits in Tsc1 +/− and Tsc2 +/− mouse models by mammalian target of rapamycin ...
10 CitationsSource
#1Bianca Völkening (Heidelberg University)H-Index: 1
#2Kai Schönig (Heidelberg University)H-Index: 22
Last. Tillmann Weber (Heidelberg University)H-Index: 10
view all 5 authors...
6 CitationsSource