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N Suff
St Thomas' Hospital
29Publications
3H-index
97Citations
Publications 29
Newest
#1Agnieszka Anna Glazewska-Hallin (St Thomas' Hospital)
#2Lisa Story (St Thomas' Hospital)H-Index: 4
Last.Andrew Shennan (St Thomas' Hospital)H-Index: 47
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#1N Suff (UCL: University College London)H-Index: 3
#2Rajvinder Karda (UCL: University College London)H-Index: 5
Last.Donald Peebles (UCL: University College London)H-Index: 31
view all 12 authors...
Approximately 40% of preterm births are preceded by microbial invasion of the intrauterine space: ascent from the vagina is the most common pathway. Within the cervical canal, antimicrobial peptides and proteins (AMPs) help to constitute a barrier which prevents ascending infection. We investigated whether expression of the AMP, human β-defensin-3 (HBD3), in the cervical mucosa prevented bacterial ascent from the vagina into the uterine cavity of pregnant mice. An adeno-associated virus vector c...
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#1Andrew Shennan ('KCL': King's College London)H-Index: 47
#2N Suff ('KCL': King's College London)H-Index: 3
Source
#1N Suff (St Thomas' Hospital)H-Index: 3
#2Lisa Story (St Thomas' Hospital)H-Index: 4
Last.Andrew Shennan (St Thomas' Hospital)H-Index: 47
view all 3 authors...
Abstract Preterm birth, defined as birth occurring prior to 37 weeks gestation, is a serious obstetric problem accounting for 11% of pregnancies worldwide. It is associated with significant neonatal morbidity and mortality. Predictive tests for preterm birth are incredibly important, given the huge personal, economic, and health impacts of preterm birth. They can provide reassurance for women who are unlikely to deliver early, but they are also important for highlighting those women at higher ri...
2 CitationsSource
#1Julien Baruteau (UCL: University College London)H-Index: 7
#2Dany P. Perocheau (UCL: University College London)H-Index: 5
Last.Simon N. Waddington (UCL: University College London)H-Index: 40
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Argininosuccinate lyase (ASL) belongs to the hepatic urea cycle detoxifying ammonia, and the citrulline-nitric oxide (NO) cycle producing NO. ASL-deficient patients present argininosuccinic aciduria characterised by hyperammonaemia, multiorgan disease and neurocognitive impairment despite treatment aiming to normalise ammonaemia without considering NO imbalance. Here we show that cerebral disease in argininosuccinic aciduria involves neuronal oxidative/nitrosative stress independent of hyperammo...
3 CitationsSource
#1N Suff (UCL: University College London)H-Index: 3
#2Rajvinder Karda (UCL: University College London)H-Index: 5
Last.Simon N. Waddington (UCL: University College London)H-Index: 40
view all 11 authors...
Preterm birth is a serious global health problem and the leading cause of infant death before 5 years of age. At least 40% of cases are associated with infection. The most common way for pathogens to access the uterine cavity is by ascending from the vagina. Bioluminescent pathogens have revolutionized the understanding of infectious diseases. We hypothesized that bioluminescent Escherichia coli can be used to track and monitor ascending vaginal infections. Two bioluminescent strains were studie...
5 CitationsSource
#1Julien Baruteau (UCL: University College London)H-Index: 7
#2Dany P. Perocheau (UCL: University College London)H-Index: 5
Last.Simon N. Waddington (UCL: University College London)H-Index: 40
view all 20 authors...
Argininosuccinate lyase (ASL) belongs to the liver-based urea cycle detoxifying ammonia, and the citrulline-nitric oxide cycle synthesising nitric oxide (NO). ASL-deficient patients present argininosuccinic aciduria characterised by hyperammonaemia and a multi-organ disease with neurocognitive impairment. Current therapeutic guidelines aim to control ammonaemia without considering the systemic NO imbalance. Here, we observed a neuronal disease with oxidative/nitrosative stress in ASL-deficient m...
Source
#1Rajvinder Karda (UCL: University College London)H-Index: 5
#2Ahad A. Rahim (UCL: University College London)H-Index: 18
Last.Simon N. Waddington (UCL: University College London)H-Index: 40
view all 15 authors...
We have previously designed a library of lentiviral vectors to generate somatic-transgenic rodents to monitor signalling pathways in diseased organs using whole-body bioluminescence imaging, in conscious, freely moving rodents. We have now expanded this technology to adeno-associated viral vectors. We first explored bio-distribution by assessing GFP expression after neonatal intravenous delivery of AAV8. We observed widespread gene expression in, central and peripheral nervous system, liver, kid...
1 CitationsSource
#1Rajvinder Karda (UCL: University College London)H-Index: 5
#2Dany P. Perocheau (UCL: University College London)H-Index: 5
Last.Simon N. Waddington (UCL: University College London)H-Index: 40
view all 12 authors...
Luciferase bioimaging in living animals is increasingly being applied in many fields of biomedical research. Rodent imaging usually involves anaesthetising the animal during data capture, however, the biological consequences of anaesthesia have been largely overlooked. We have evaluated luciferase bioimaging in conscious, unrestrained mice after neonatal intracranial or intravascular administration of lentiviral, luciferase reporter cassettes (biosensors); we present real-time analyses from the ...
5 CitationsSource
#1N SuffH-Index: 3
#2Rajvinder KardaH-Index: 5
Last.Simon N. WaddingtonH-Index: 40
view all 8 authors...
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