Li Chen
University of Oxford
EndocrinologyGene expressionBrain-derived neurotrophic factorGlutamate receptorBiology
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Publications 6
#1Sarah H. Williams (University of Oxford)H-Index: 2
#2Li Chen (University of Oxford)H-Index: 6
Last. Philip W.J. Burnet (University of Oxford)H-Index: 31
view all 6 authors...
Compelling data suggest that perturbations in microbial colonization of the gut in early-life, influences neurodevelopment and adult brain function. If this is the case, then ensuring the growth of beneficial bacteria at an early age will lead to optimal brain development and maturation. We have tested whether feeding neonatal rats daily (from post-natal days 3-21) with a galacto-oligosaccharide prebiotic (Bimuno®, BGOS) or a control solution, alters the levels of hippocampal N-Methyl-D-Aspartat...
28 CitationsSource
#1Helene M. Savignac (University of Oxford)H-Index: 1
#2Giulia Corona (University of Reading)H-Index: 23
Last. Philip W.J. Burnet (University of Oxford)H-Index: 31
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The influence of the gut microbiota on brain chemistry has been convincingly demonstrated in rodents. In the absence of gut bacteria, the central expression of brain derived neurotropic factor, (BDNF), and N-methyl-d-aspartate receptor (NMDAR) subunits are reduced, whereas, oral probiotics increase brain BDNF, and impart significant anxiolytic effects. We tested whether prebiotic compounds, which increase intrinsic enteric microbiota, also affected brain BDNF and NMDARs. In addition, we examined...
119 CitationsSource
#1Philip W.J. Burnet (University of Oxford)H-Index: 31
#2Patrick N. Anderson (UCL: University College London)H-Index: 39
Last. Matthew J.A. Wood (University of Oxford)H-Index: 66
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Abstract Virus mediated RNA-interference (RNAi) is a powerful approach to study genes in vivo . Here we report a method using lentivirus-delivered RNAi to knockdown the glial enzyme, d -amino acid oxidase (DAO), in the mouse cerebellum. After initial characterisation in vitro , we achieved a 40–50% reduction of DAO mRNA in the cerebellum 7 and 28 days after a single injection of lentivirus encoding a DAO-specific, short-hairpin RNA. Injections also decreased DAO immunoreactivity (−33%). The majo...
18 CitationsSource
#1Greg C. Bristow (Warneford Hospital)H-Index: 6
#2Tracy A. Lane (Warneford Hospital)H-Index: 1
Last. Sharon L. Eastwood (Warneford Hospital)H-Index: 23
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Single nucleotide polymorphisms (SNPs) within the gene encoding the serine/threonine kinase KIS (Kinase Interacting with Stathmin, also known as UHMK1) have recently been associated with schizophrenia. As none of the disease associated SNPs are coding, they may confer susceptibility by altering some facet of KIS expression. Here we have characterised the cellular distribution of KIS in human brain using in situ hybridisation and immunohistochemistry, and quantified KIS protein and mRNA in two la...
6 CitationsSource
#1Ed S. Lein (Allen Institute for Brain Science)H-Index: 37
#2Michael Hawrylycz (Allen Institute for Brain Science)H-Index: 42
Last. Allan R. Jones (Allen Institute for Brain Science)H-Index: 34
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The expression of each of the roughly 22,000 genes of the mouse genome has been mapped, at cellular resolution, across all major structures of the mouse brain, revealing that 80% of all genes appear to be expressed in the brain.
2,917 CitationsSource
#1J. F. Watkins (University of Oxford)H-Index: 5
#2Li Chen (University of Oxford)H-Index: 6
A hybrid of Ehrlich ascites tumour cells and polyoma-transformed hamster cells can be used to immunize mice against the Ehrlich ascites tumour. The hybrid cell is analogous to an attenuated tumour cell and this method of tumour immunization can be adapted for the detection of tumour antigens.
55 CitationsSource