Mark W. Moore
GeneMolecular biologyReceptorImmunologyBiology
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Publications 46
#1Bret A. Moore (Veterinary Medical Teaching Hospital)H-Index: 4
#3Brian C. Leonard (UC Davis: University of California, Davis)H-Index: 16
Last. Ala Moshiri (Vision-Sciences, Inc.)H-Index: 8
view all 69 authors...
In the original published version of the article, Valerie Vancollie was mistakenly omitted from the list of members of the International Mouse Phenotyping Consortium. In addition, recognition of funding from Wellcome Trust grant WT098051 was mistakenly omitted from the Acknowledgements.The errors have been corrected in both the PDF and HTML versions of the paper.
1 CitationsSource
#1Bret A. Moore (Veterinary Medical Teaching Hospital)H-Index: 4
#2Brian C. Leonard (UC Davis: University of California, Davis)H-Index: 16
Last. Ala Moshiri (UC Davis: University of California, Davis)H-Index: 8
view all 69 authors...
Despite advances in next generation sequencing technologies, determining the genetic basis of ocular disease remains a major challenge due to the limited access and prohibitive cost of human forward genetics. Thus, less than 4,000 genes currently have available phenotype information for any organ system. Here we report the ophthalmic findings from the International Mouse Phenotyping Consortium, a large-scale functional genetic screen with the goal of generating and phenotyping a null mutant for ...
6 CitationsSource
#1Jan RozmanH-Index: 30
#2Birgit Rathkolb (LMU: Ludwig Maximilian University of Munich)H-Index: 29
Last. Martin Hrabé de Angelis (TUM: Technische Universität München)H-Index: 46
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Metabolic diseases are a worldwide problem but the underlying genetic factors and their relevance to metabolic disease remain incompletely understood. Genome-wide research is needed to characterize so-far unannotated mammalian metabolic genes. Here, we generate and analyze metabolic phenotypic data of 2016 knockout mouse strains under the aegis of the International Mouse Phenotyping Consortium (IMPC) and find 974 gene knockouts with strong metabolic phenotypes. 429 of those had no previous link ...
18 CitationsSource
#1Michael R. Bowl (Medical Research Council)H-Index: 21
#2Michelle M. Simon (Medical Research Council)H-Index: 15
Last. Steve D.M. Brown (Medical Research Council)H-Index: 57
view all 49 authors...
The developmental and physiological complexity of the auditory system is likely reflected in the underlying set of genes involved in auditory function. In humans, over 150 non-syndromic loci have been identified, and there are more than 400 human genetic syndromes with a hearing loss component. Over 100 non-syndromic hearing loss genes have been identified in mouse and human, but we remain ignorant of the full extent of the genetic landscape involved in auditory dysfunction. As part of the Inter...
27 CitationsSource
#1Terrence F. MeehanH-Index: 18
#2Nathalie ConteH-Index: 19
Last. Damian Smedley (QMUL: Queen Mary University of London)H-Index: 40
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Damian Smedley and colleagues report the phenotypic characterization of the first 3,328 genes by the International Mouse Phenotyping Consortium. They develop new mouse models based on genes known to be associated with human mendelian diseases and identify potential disease-associated genes with little or no previous functional annotation.
78 CitationsSource
#1Mary E. DickinsonH-Index: 44
#2Ann M. Flenniken (U of T: University of Toronto)H-Index: 18
Last. Stephen A. MurrayH-Index: 31
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Identification and characterization, using a comprehensive embryonic phenotyping pipeline, of 410 lethal alleles during the generation of the first 1,751 of 5,000 unique gene knockouts produced by the International Mouse Phenotyping Consortium.
254 CitationsSource
#1Cornelia KaloffH-Index: 2
#2Konstantinos Anastassiadis (TUD: Dresden University of Technology)H-Index: 37
Last. Wolfgang WurstH-Index: 79
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The International Knockout Mouse Consortium (IKMC) developed high throughput gene trapping and gene targeting pipelines that produced mostly conditional mutations of more than 18,500 genes in C57BL/6N mouse embryonic stem (ES) cells which have been archived and are freely available to the research community as a frozen resource. From this unprecedented resource more than 6000 mutant mouse strains have been generated by the IKMC in collaboration with the International Mouse Phenotyping Consortium...
1 CitationsSource
#1Kevin C K Lloyd (UC Davis: University of California, Davis)H-Index: 35
#2Terry Meehan (EMBL-EBI: European Bioinformatics Institute)H-Index: 2
Last. Mark W. MooreH-Index: 31
view all 12 authors...
By all accounts, President Obama's Precision Medicine Initiative (PMI) promising molecular-guided diagnostics, therapeutics, and prevention strategies is eliciting enthusiasm and excitement among clinicians, translational researchers, and patients (“NIH plots million-person megastudy,” J. Kaiser
5 CitationsSource
#1Donna Eaton (TGH: Toronto General Hospital)
#2A. Mariscal (TGH: Toronto General Hospital)
Last. M. de Perrot (TGH: Toronto General Hospital)H-Index: 16
view all 7 authors...