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Keon Mook Seong
Michigan State University
13Publications
5H-index
53Citations
Publications 13
Newest
#1Keon Mook Seong (MSU: Michigan State University)H-Index: 5
#2Brad S. Coates (ARS: Agricultural Research Service)H-Index: 22
Last.Barry Robert Pittendrigh (MSU: Michigan State University)H-Index: 25
view all 3 authors...
Abstract Cytochrome P450s are part of a super-gene family that has undergone gene duplication, divergence, over-expression and, in some cases, loss of function. One such case is the 91-R and 91-C strains of common origin, in Drosophila melanogaster , whereby 91-R (DDT resistant strain) overexpresses Cyp4p1 and Cyp4p2 and both genes are lost in 91-C (DDT susceptible strain). In this study, we used a comparative approach to demonstrate that transcription of Cyp4p1 and Cyp4p2 were constitutively up...
#1Keon Mook Seong (MSU: Michigan State University)H-Index: 5
Last.Barry Robert Pittendrigh (MSU: Michigan State University)H-Index: 25
view all 4 authors...
Abstract While insecticide resistance presents a challenge for those intent on controlling insect populations, these challenges have also generated a set of tools that can be used to ask fundamental biological questions about that resistance. Numerous species of insects have evolved resistance to multiple classes of insecticides. Each one of these species and their respective resistant populations represent a potential tool for understanding the molecular basis of the evolution of resistance. Ho...
#1Keon Mook SeongH-Index: 5
#2Brad S. CoatesH-Index: 22
Last.Barry Robert PittendrighH-Index: 25
view all 3 authors...
Ten constitutively differentially expressed miRNAs were previously described between DDT-resistant 91-R and -susceptible control Drosophila melanogaster strains, and among their predicted target genes were those associated with metabolic DDT resistance mechanisms. The present study evaluated the inducibility of miRNA expression and putative downstream regulation of cytochrome P450s in response to DDT exposure in a time-dependent manner in 91-R and the susceptible Canton-S strain. Specifically, R...
#1Laura D. Steele (UIUC: University of Illinois at Urbana–Champaign)H-Index: 5
#2Brad S. Coates (USDA: United States Department of Agriculture)H-Index: 22
Last.Barry Robert Pittendrigh (MSU: Michigan State University)H-Index: 25
view all 8 authors...
#1Laura D. Steele (UIUC: University of Illinois at Urbana–Champaign)H-Index: 5
#2Weilin Sun (MSU: Michigan State University)H-Index: 13
Last.Barry Robert Pittendrigh (MSU: Michigan State University)H-Index: 25
view all 9 authors...
Abstract The brown pod-sucking bug, Clavigralla tomentosicollis Stal (Hemiptera: Coreidae), causes significant damage to cultivated cowpea, Vigna unguiculata Walp, a staple crop in sub-Saharan Africa. C. tomentosicollis pierce and suck sap from cowpea pods, resulting in reduced grain yield and quality. The complete, 16,089 bp mitogenome of C. tomentosicollis encodes 13 protein-coding genes (PCGs), 22 transfer RNAs (tRNAs), two ribosomal RNAs (rRNAs) and an A + T rich control region, with gene or...
#1Keon Mook Seong (UIUC: University of Illinois at Urbana–Champaign)H-Index: 5
#2Weilin Sun (UIUC: University of Illinois at Urbana–Champaign)H-Index: 13
Last.Barry Robert Pittendrigh (UIUC: University of Illinois at Urbana–Champaign)H-Index: 25
view all 4 authors...
The ATP-binding cassette (ABC) transporters represent a superfamily of proteins that have important physiological roles in both prokaryotes and eukaryotes. In insects, ABC transporters have previously been implicated in insecticide resistance. The 91-R strain of Drosophila melanogaster has been intensely selected with DDT over six decades. A recent selective sweeps analysis of 91-R implicated the potential role of MDR49, an ABC transporter, in DDT resistance, however, to date the details of how ...
#1Laura D. Steele (UIUC: University of Illinois at Urbana–Champaign)H-Index: 5
#2Brad S. Coates (Iowa State University)H-Index: 22
Last.Barry Robert Pittendrigh (UIUC: University of Illinois at Urbana–Champaign)H-Index: 25
view all 8 authors...
Adaptation of insect phenotypes for survival after exposure to xenobiotics can result from selection at multiple loci with additive genetic effects. To the authors’ knowledge, no selective sweep analysis has been performed to identify such loci in highly dichlorodiphenyltrichloroethane (DDT) resistant insects. Here we compared a highly DDT resistant phenotype in the Drosophila melanogaster (Drosophila) 91-R strain to the DDT susceptible 91-C strain, both of common origin. Whole genome re-sequenc...
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