Branding/Logomark Created with Sketch. minus Created with Sketch. arrow-point-to-down Created with Sketch. Citation Created with Sketch. Combined Shape Created with Sketch. Icon/Copy Created with Sketch. 2AC24B92-E380-4A24-A7FB-E0AC4B6F468D Created with sketchtool. ADDA8D13-C2F5-4358-9B0E-1C359912CA41 Created with sketchtool.
Loading Scinapse...
Svante Pääbo
Max Planck Society
Citations
49070
H-index
118
Publications 390
Most Citations
Thomas Kocher58
Estimated H-index: 58
("University of California, Berkeley"),
Scott V. Edwards60
Estimated H-index: 60
("University of California, Berkeley"),
Axel Meyer74
Estimated H-index: 74
("University of California, Berkeley")
... (4 others)
Abstract With a standard set of primers directed toward conserved regions, we have used the polymerase chain reaction to amplify homologous segments of mtDNA from more than 100 animal species, including mammals, birds, amphibians, fishes, and some invertebrates. Amplification and direct sequencing were possible using unpurified mtDNA from nanogram samples of fresh specimens and microgram amounts o...
Cited 3661 Download Pdf Cite this paper
2010 in Science [IF: 37.20]
Nick Patterson92
Estimated H-index: 92
(Broad Institute),
Udo Stenzel21
Estimated H-index: 21
(Max Planck Society),
Johannes Krause55
Estimated H-index: 55
(Max Planck Society)
... (6 others)
Neandertals, the closest evolutionary relatives of present-day humans, lived in large parts of Europe and western Asia before disappearing 30,000 years ago. We present a draft sequence of the Neandertal genome composed of more than 4 billion nucleotides from three individuals. Comparisons of the Neandertal genome to the genomes of five present-day humans from different parts of the world identify ...
Cited 1735 Download Pdf Cite this paper
2005 in Nature [IF: 40.14]
Tarjei S. Mikkelsen46
Estimated H-index: 46
(Broad Institute),
Michael C. Zody46
Estimated H-index: 46
(Broad Institute),
Shiaw-Pyng Yang22
Estimated H-index: 22
(Max Planck Society)
... (6 others)
Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we have generated a largely complete catalogue of the genetic differenc ...
Ref 181Cited 1603 Download Pdf Cite this paper
2007 in Nature Genetics [IF: 27.96]
Michael Weber25
Estimated H-index: 25
(Friedrich Miescher Institute for Biomedical Research),
Ines Hellmann24
Estimated H-index: 24
(Max Planck Society),
Liliana Ramos22
Estimated H-index: 22
(Radboud University Nijmegen)
... (4 others)
To gain insight into the function of DNA methylation at cis-regulatory regions and its impact on gene expression, we measured methylation, RNA polymerase occupancy and histone modifications at 16,000 promoters in primary human somatic and germline cells. We find CpG-poor promoters hypermethylated in somatic cells, which does not preclude their activity. This methylation is present in male gametes ...
Ref 51Cited 1417 Download Pdf Cite this paper
2000 in Nature [IF: 40.14]
Max Ingman13
Estimated H-index: 13
(Uppsala University),
Svante Pääbo118
Estimated H-index: 118
(Max Planck Society),
Henrik Kaessmann37
Estimated H-index: 37
(Max Planck Society)
... (1 others)
Mitochondrial DNA (mtDNA) has been a potent tool in studies of the evolution of modern humans, human migrations and the dynamics of human populations over time. The popularity of this cytoplasmic genome has largely been due to its clonal inheritance (in Man) allowing the tracing of a direct genetic line. In addition, a comparatively high rate of nucleotide substitution facilitates phylogenetic res...
Ref 31Cited 1073 Download Pdf Cite this paper
2002 in Nature [IF: 40.14]
Svante Pääbo118
Estimated H-index: 118
(Max Planck Society),
Cecilia S. L. Lai7
Estimated H-index: 7
(Wellcome Trust),
Victor Wiebe15
Estimated H-index: 15
(Max Planck Society)
... (5 others)
Abstract Language is a uniquely human trait likely to have been a prerequisite for the development of human culture. The ability to develop articulate speech relies on capabilities, such as fine control of the larynx and mouth, that are absent in chimpanzees and other great apes. FOXP2 is the first gene relevant to the human ability to develop language. A point mutation in FOXP2 co-segregates with...
Cited 946 Download Pdf Cite this paper
1997 in Cell [IF: 30.41]
Svante Pääbo118
Estimated H-index: 118
(Ludwig Maximilian University of Munich),
Ralf W. Schmitz6
Estimated H-index: 6
(University of Tübingen),
Anne C. Stone32
Estimated H-index: 32
(Pennsylvania State University)
... (3 others)
Abstract DNA was extracted from the Neandertal-type specimen found in 1856 in western Germany. By sequencing clones from short overlapping PCR products, a hitherto unknown mitochondrial (mt) DNA sequence was determined. Multiple controls indicate that this sequence is endogenous to the fossil. Sequence comparisons with human mtDNA sequences, as well as phylogenetic analyses, show that the Neandert...
Cited 846 Download Pdf Cite this paper
2010 in Nature [IF: 40.14]
Eric Y. Durand10
Estimated H-index: 10
("University of California, Berkeley"),
Martin Kircher33
Estimated H-index: 33
(Max Planck Society),
Johannes Krause55
Estimated H-index: 55
(Max Planck Society)
... (6 others)
Using DNA extracted from a finger bone found in Denisova Cave in southern Siberia, we have sequenced the genome of an archaic hominin to about 1.9-fold coverage. This individual is from a group that shares a common origin with Neanderthals. This population was not involved in the putative gene flow from Neanderthals into Eurasians; however, the data suggest that it contributed 4–6% of its genetic ...
Ref 38Cited 831 Download Pdf Cite this paper
2012 in Science [IF: 37.20]
Fernando Racimo13
Estimated H-index: 13
(Max Planck Society),
Joshua G. Schraiber12
Estimated H-index: 12
("University of California, Berkeley"),
Heng Li37
Estimated H-index: 37
(Massachusetts Institute of Technology)
... (6 others)
Draft genome sequences have been recovered from two archaic human groups, Neandertals (1) and Denisovans (2). While Neandertals are defined by distinct morphological features and occur in the fossil record of Europe, Western and Central Asia from at least 230,000 until about 30,000 years ago (3), Denisovans are known only from a distal manual phalanx and two molars, all excavated at Denisova Cave ...
Cited 713 Download Pdf Cite this paper
2002 in Science [IF: 37.20]
Philipp Khaitovich43
Estimated H-index: 43
(Max Planck Society),
Ajit Varki76
Estimated H-index: 76
("University of California, San Diego"),
Florian Heissig4
Estimated H-index: 4
(Max Planck Society)
... (6 others)
Although humans and their closest evolutionary relatives, the chimpanzees, are 98.7% identical in their genomic DNA sequences, they differ in many morphological, behavioral, and cognitive aspects. The underlying genetic basis of many of these differences may be altered gene expression. We have compared the transcriptome in blood leukocytes, liver, and brain of humans, chimpanzees, orangutans, and ...
Cited 685 Download Pdf Cite this paper
12345678910