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Svante Pääbo
Max Planck Society
403Publications
120H-index
48.8kCitations
Publications 403
Newest
Martin Petr2
Estimated H-index: 2
(Max Planck Society),
Svante Pääbo120
Estimated H-index: 120
(Max Planck Society)
+ 1 AuthorsBenjamin Vernot18
Estimated H-index: 18
(Max Planck Society)
Several studies have suggested that introgressed Neandertal DNA was subjected to negative selection in modern humans due to deleterious alleles that had accumulated in the Neandertals after they split from the modern human lineage. A striking observation in support of this is an apparent monotonic decline in Neandertal ancestry observed in modern humans in Europe over the past 45 thousand years. Here we show that this apparent decline is an artifact caused by gene flow between West Eurasians and...
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2019 in Current BiologyIF: 9.25
Philipp Gunz34
Estimated H-index: 34
(Max Planck Society),
Amanda K. Tilot1
Estimated H-index: 1
(Max Planck Society)
+ 24 AuthorsTulio Guadalupe14
Estimated H-index: 14
(Max Planck Society)
Summary One of the features that distinguishes modern humans from our extinct relatives and ancestors is a globular shape of the braincase [1–4]. As the endocranium closely mirrors the outer shape of the brain, these differences might reflect altered neural architecture [4, 5]. However, in the absence of fossil brain tissue, the underlying neuroanatomical changes as well as their genetic bases remain elusive. To better understand the biological foundations of modern human endocranial shape, we t...
1 Citations Download PDF Cite
2018 in Scientific ReportsIF: 4.12
Bart Van Laer (European Synchrotron Radiation Facility), Ulrike Kapp11
Estimated H-index: 11
(European Synchrotron Radiation Facility)
+ 4 AuthorsChristoph Mueller-Dieckmann12
Estimated H-index: 12
(European Synchrotron Radiation Facility)
The availability of genomic data from extinct homini such as Neanderthals has caused a revolution in palaeontology allowing the identification of modern human-specific protein substitutions. Currently, little is known as to how these substitutions alter the proteins on a molecular level. Here, we investigate adenylosuccinate lyase, a conserved enzyme involved in purine metabolism for which several substitutions in the modern human protein (hADSL) have been described to affect intelligence and be...
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2018 in NatureIF: 41.58
Viviane Slon11
Estimated H-index: 11
(Max Planck Society),
Fabrizio Mafessoni4
Estimated H-index: 4
(Max Planck Society)
+ 16 AuthorsSamantha Brown2
Estimated H-index: 2
(Max Planck Society)
Neanderthals and Denisovans are extinct groups of hominins that separated from each other more than 390,000 years ago1,2. Here we present the genome of ‘Denisova 11’, a bone fragment from Denisova Cave (Russia)3 and show that it comes from an individual who had a Neanderthal mother and a Denisovan father. The father, whose genome bears traces of Neanderthal ancestry, came from a population related to a later Denisovan found in the cave4–6. The mother came from a population more closely related t...
16 Citations Download PDF Cite
2018 in bioRxiv
Michael Dannemann14
Estimated H-index: 14
(Max Planck Society),
Benjamin Vernot18
Estimated H-index: 18
(Max Planck Society)
+ 2 AuthorsJ. Gray Camp6
Estimated H-index: 6
(Max Planck Society)
Pluripotent stem cells from diverse humans offer the potential to study human functional variation in controlled culture environments. A portion of this variation originates from ancient admixture between modern humans and Neandertals, which introduced alleles that left a phenotypic legacy on individual humans today. Here we show that a large repository of human induced pluripotent stem cells (iPSCs) harbors extensive Neandertal DNA, including most known functionally relevant Neandertal alleles ...
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2018 in CellIF: 31.40
Benjamin Vernot18
Estimated H-index: 18
(Max Planck Society),
Svante Pääbo120
Estimated H-index: 120
(Max Planck Society)
By examining the genomes of present-day people from Asia, researchers show that modern humans met and interbred with Denisovans, distant relatives to Neanderthals, on at least two occasions. As a result, people today carry DNA from two different Denisovan populations.
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2018 in Nature CommunicationsIF: 12.35
Thiseas Christos Lamnidis2
Estimated H-index: 2
(Max Planck Society),
Kerttu Majander1
Estimated H-index: 1
(Max Planck Society)
+ 14 AuthorsAntje Weihmann6
Estimated H-index: 6
(Max Planck Society)
European population history has been shaped by migrations of people, and their subsequent admixture. Recently, ancient DNA has brought new insights into European migration events linked to the advent of agriculture, and possibly to the spread of Indo-European languages. However, little is known about the ancient population history of north-eastern Europe, in particular about populations speaking Uralic languages, such as Finns and Saami. Here we analyse ancient genomic data from 11 individuals f...
3 Citations Download PDF Cite
2018 in NatureIF: 41.58
Mateja Hajdinjak9
Estimated H-index: 9
(Max Planck Society),
Qiaomei Fu21
Estimated H-index: 21
+ 28 AuthorsIsabelle Crevecoeur14
Estimated H-index: 14
Many questions remain about the relationship between populations of Neanderthals around the time of their final interactions with modern humans, and how this contributed to the evolution of modern humans. Janet Kelso, Svante Paabo and colleagues sequenced the genomes of five Neanderthals that lived between 39,000 and 47,000 years ago, broadening the temporal and geographical range of available Neanderthal genomes. They analyse these genomes together with previously sequenced ancient genomes and ...
14 Citations Download PDF Cite
2018 in ScienceIF: 41.06
Marieke Sophia van de Loosdrecht1
Estimated H-index: 1
(Max Planck Society),
Abdeljalil Bouzouggar13
Estimated H-index: 13
(Max Planck Society)
+ 15 AuthorsMohammed Abdeljalil El Hajraoui1
Estimated H-index: 1
North Africa is a key region for understanding human history, but the genetic history of its people is largely unknown. We present genomic data from seven 15,000-year-old modern humans from Morocco, attributed to the Iberomaurusian culture. We find a genetic affinity with early Holocene Near Easterners, best represented by Levantine Natufians, suggesting a pre-agricultural connection between Africa and the Near East. We do not find evidence for gene flow from Paleolithic Europeans into Late Plei...
8 Citations Download PDF Cite
2017
Thibaut Devièse7
Estimated H-index: 7
,
Ivor Karavanić13
Estimated H-index: 13
+ 7 AuthorsThomas Higham56
Estimated H-index: 56
The period between ~45, 000 and 35, 000 14C years BP in Europe witnessed the “biocultural” transition from the Middle to early Upper Palaeolithic, when anatomically modern humans from Africa displaced Neanderthals across the continent. Significant questions remain regarding how this transition happened, for example to what extent Neanderthals and modern humans overlapped temporally and spatially, if modern humans or Neanderthals were responsible for various ‘transitional’ early Upper Palaeolithi...
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