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Svante Pääbo
Max Planck Society
Citations
46136
H-index
117
Publications 386
Most Citations
DYNAMICS OF MITOCHONDRIAL DNA EVOLUTION IN ANIMALS: AMPLIFICATION AND SEQUENCING WITH CONSERVED PRIMERS
Thomas Kocher49
Estimated H-index: 49
(University of Maryland, College Park),
W.K. Thomas2
Estimated H-index: 2
(Ludwig Maximilian University of Munich),
A. Meyer1
Estimated H-index: 1
... (4 others)
Abstract With a standard set of primers directed toward conserved regions, we have used the polymerase chain reaction to amplify homologous segments of mtDNA from more than 100 animal species, including mammals, birds, amphibians, fishes, and some invertebrates. Amplification and direct sequencing were possible using unpurified mtDNA from nanogram samples of fresh specimens and microgram amounts o...
Cited 3538 Download Pdf Cite this paper Add Collection
A Draft Sequence of the Neandertal Genome
2010 in Science [IF: 37.20]
Richard E. Green39
Estimated H-index: 39
(Max Planck Society),
Johannes Krause45
Estimated H-index: 45
(Max Planck Society),
Adrian W. Briggs19
Estimated H-index: 19
(Max Planck Society)
... (7 others)
Neandertals, the closest evolutionary relatives of present-day humans, lived in large parts of Europe and western Asia before disappearing 30,000 years ago. We present a draft sequence of the Neandertal genome composed of more than 4 billion nucleotides from three individuals. Comparisons of the Neandertal genome to the genomes of five present-day humans from different parts of the world identify ...
Ref 142Cited 1597 Download Pdf Cite this paper Add Collection
Initial sequence of the chimpanzee genome and comparison with the human genome
2005 in Nature [IF: 40.14]
Tarjei S. Mikkelsen1
Estimated H-index: 1
(University of Washington),
LaDeana W. Hillier57
Estimated H-index: 57
(Broad Institute),
Evan E. Eichler1
Estimated H-index: 1
(Broad Institute)
... (5 others)
Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we have generated a largely complete catalogue of the genetic differenc ...
Ref 181Cited 1546 Download Pdf Cite this paper Add Collection
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
2007 in Nature Genetics [IF: 27.96]
Michael Weber36
Estimated H-index: 36
(University of Strasbourg),
Ines Hellmann23
Estimated H-index: 23
(Max Planck Society),
Michael B. Stadler34
Estimated H-index: 34
(Friedrich Miescher Institute for Biomedical Research)
... (4 others)
To gain insight into the function of DNA methylation at cis-regulatory regions and its impact on gene expression, we measured methylation, RNA polymerase occupancy and histone modifications at 16,000 promoters in primary human somatic and germline cells. We find CpG-poor promoters hypermethylated in somatic cells, which does not preclude their activity. This methylation is present in male gametes ...
Ref 51Cited 1333 Download Pdf Cite this paper Add Collection
Mitochondrial genome variation and the origin of modern humans
2000 in Nature [IF: 40.14]
Max Ingman12
Estimated H-index: 12
(Uppsala University),
Henrik Kaessmann33
Estimated H-index: 33
(Max Planck Society),
Svante Pääbo117
Estimated H-index: 117
(Max Planck Society)
... (1 others)
Mitochondrial DNA (mtDNA) has been a potent tool in studies of the evolution of modern humans, human migrations and the dynamics of human populations over time. The popularity of this cytoplasmic genome has largely been due to its clonal inheritance (in Man) allowing the tracing of a direct genetic line. In addition, a comparatively high rate of nucleotide substitution facilitates phylogenetic res...
Ref 31Cited 1028 Download Pdf Cite this paper Add Collection
Molecular evolution of FOXP2, a gene involved in speech and language.
2002 in Nature [IF: 40.14]
Wolfgang Enard30
Estimated H-index: 30
(Max Planck Society),
Molly Przeworski43
Estimated H-index: 43
(Max Planck Society),
Simon E. Fisher58
Estimated H-index: 58
(Wellcome Trust)
... (5 others)
Abstract Language is a uniquely human trait likely to have been a prerequisite for the development of human culture. The ability to develop articulate speech relies on capabilities, such as fine control of the larynx and mouth, that are absent in chimpanzees and other great apes. FOXP2 is the first gene relevant to the human ability to develop language. A point mutation in FOXP2 co-segregates with...
Ref 31Cited 902 Download Pdf Cite this paper Add Collection
Neandertal DNA sequences and the origin of modern humans
1997 in Cell [IF: 30.41]
Matthias Krings11
Estimated H-index: 11
(Ludwig Maximilian University of Munich),
Anne C. Stone28
Estimated H-index: 28
(Pennsylvania State University),
Ralf W. Schmitz7
Estimated H-index: 7
(University of Tübingen)
... (3 others)
Abstract DNA was extracted from the Neandertal-type specimen found in 1856 in western Germany. By sequencing clones from short overlapping PCR products, a hitherto unknown mitochondrial (mt) DNA sequence was determined. Multiple controls indicate that this sequence is endogenous to the fossil. Sequence comparisons with human mtDNA sequences, as well as phylogenetic analyses, show that the Neandert...
Ref 48Cited 812 Download Pdf Cite this paper Add Collection
Genetic history of an archaic hominin group from Denisova Cave in Siberia
2010 in Nature [IF: 40.14]
David Reich86
Estimated H-index: 86
(Harvard University),
Richard E. Green39
Estimated H-index: 39
(Max Planck Society),
Martin Kircher31
Estimated H-index: 31
(Max Planck Society)
... (7 others)
Using DNA extracted from a finger bone found in Denisova Cave in southern Siberia, we have sequenced the genome of an archaic hominin to about 1.9-fold coverage. This individual is from a group that shares a common origin with Neanderthals. This population was not involved in the putative gene flow from Neanderthals into Eurasians; however, the data suggest that it contributed 4–6% of its genetic ...
Ref 38Cited 774 Download Pdf Cite this paper Add Collection
Intra- and Interspecific Variation in Primate Gene Expression Patterns
2002 in Science [IF: 37.20]
Wolfgang Enard30
Estimated H-index: 30
(Max Planck Society),
Philipp Khaitovich39
Estimated H-index: 39
(Max Planck Society),
Joachim Klose33
Estimated H-index: 33
(Charité)
... (7 others)
Although humans and their closest evolutionary relatives, the chimpanzees, are 98.7% identical in their genomic DNA sequences, they differ in many morphological, behavioral, and cognitive aspects. The underlying genetic basis of many of these differences may be altered gene expression. We have compared the transcriptome in blood leukocytes, liver, and brain of humans, chimpanzees, orangutans, and ...
Ref 14Cited 658 Download Pdf Cite this paper Add Collection
A High-Coverage Genome Sequence from an Archaic Denisovan Individual
2012 in Science [IF: 37.20]
Matthias Meyer45
Estimated H-index: 45
(Max Planck Society),
Martin Kircher31
Estimated H-index: 31
(Max Planck Society),
Marie Theres Gansauge1
Estimated H-index: 1
(Max Planck Society)
... (7 others)
Draft genome sequences have been recovered from two archaic human groups, Neandertals (1) and Denisovans (2). While Neandertals are defined by distinct morphological features and occur in the fossil record of Europe, Western and Central Asia from at least 230,000 until about 30,000 years ago (3), Denisovans are known only from a distal manual phalanx and two molars, all excavated at Denisova Cave ...
Ref 196Cited 647 Download Pdf Cite this paper Add Collection
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Co-Authors 5
Ines HellmannH-index : 23
Ludwig Maximilian University of Munich
Wolfgang EnardH-index : 30
Ludwig Maximilian University of Munich
University of Chicago
Thomas KocherH-index : 49
University of Maryland, College Park
Dirk SchübelerH-index : 57
Friedrich Miescher Institute for Biomedical Research