Bénédicte Ballanger
Claude Bernard University Lyon 1
Publications 46
#1Charlotte SpayH-Index: 2
#2Garance MeyerH-Index: 1
Last.Philippe BoulinguezH-Index: 19
view all 7 authors...
Abstract Objectives Impulse control disorders (ICDs) in Parkinson’s disease (PD) have been associated with cognitive impulsivity and dopaminergic dysfunction and treatment. The present study tests the neglected hypothesis that the neurofunctional networks involved in motor impulsivity might also be dysfunctional in PD-ICDs. Methods We performed blind spectral analyses of resting state electroencephalographic (EEG) data in PD patients with and without ICDs to probe the functional integrity of all...
#1Bénédicte Ballanger (French Institute of Health and Medical Research)H-Index: 21
#2Kevin G. Bath (Brown University)H-Index: 31
Last.Nathalie Mandairon (French Institute of Health and Medical Research)H-Index: 6
view all 3 authors...
Abstract Anxiety disorders represent one of the most common classes of psychiatric disorders. In the aging population and for patients with age-related pathology, the percentage of people suffering of anxiety is significantly elevated. Further, anxiety carries with it an increased risk for a variety of age-related medical conditions, including cardiovascular disease, stroke, cognitive decline, and increased severity of motor symptoms in Parkinson’s disease. A variety of anxiolytic compounds are ...
#1Garance Meyer (UCBL: Claude Bernard University Lyon 1)H-Index: 1
#2Charlotte Spay (UCBL: Claude Bernard University Lyon 1)H-Index: 2
Last.Philippe Boulinguez (UCBL: Claude Bernard University Lyon 1)H-Index: 19
view all 6 authors...
Abstract Impulse control disorders (ICDs) in Parkinson’s disease (PD) are associated with dopaminergic dysfunction and treatment, but have no satisfactory therapeutic solution. While studies assessing the neurofunctional bases of ICDs are important for advancing our understanding and management of ICDs, they remain sparse and inconsistent. Based on a systematic analysis of the neuroimaging literature, the present review pinpoints various abnormalities beyond the mesocorticolimbic circuit that su...
2 CitationsSource
#1Charlotte Spay (UCBL: Claude Bernard University Lyon 1)H-Index: 2
#2Garance Meyer (UCBL: Claude Bernard University Lyon 1)H-Index: 1
Last.Bénédicte Ballanger (UCBL: Claude Bernard University Lyon 1)H-Index: 21
view all 6 authors...
Abstract Akinesia is a major manifestation of Parkinson's disease (PD) related to difficulties or failures of willed movement to occur. Akinesia is still poorly understood and is not fully alleviated by standard therapeutic strategies. One reason is that the area of the clinical concept has blurred boundaries referring to confounded motor symptoms. Here, we review neuroimaging studies which, by providing access to finer-grained mechanisms, have the potential to reveal the dysfunctional brain pro...
1 CitationsSource
#1Guillaume Lio (University of Lyon)H-Index: 5
#2Stéphane ThoboisH-Index: 29
Last.Philippe Boulinguez (French Institute of Health and Medical Research)H-Index: 1
view all 5 authors...
Abstract A major question for deep brain stimulation (DBS) research is understanding how DBS of one target area modulates activity in different parts of the brain. EEG gives privileged access to brain dynamics, but its use with implanted patients is limited since DBS adds significant high-amplitude electrical artifacts that can completely obscure neural activity measured using EEG. Here, we systematically review and discuss the methods available for removing DBS artifacts. These include simple t...
1 CitationsSource
#1Charlotte SpayH-Index: 2
#2Marion AlbaresH-Index: 4
Last.Philippe BoulinguezH-Index: 19
view all 8 authors...
Clonidine is an anti-hypertensive medication which acts as an alpha-adrenergic receptor agonist. As the noradrenergic system is likely to support cognitive functions including attention and executive control, other clinical uses of clonidine have recently gained popularity for the treatment of neuropsychiatric disorders like attention-deficit hyperactivity disorder or Tourette syndrome, but the mechanism of action is still unclear. Here, we test the hypothesis that the noradrenergic system regul...
3 CitationsSource
#1Marion CriaudH-Index: 8
#2Marieke Longcamp (AMU: Aix-Marseille University)H-Index: 8
Last.Philippe BoulinguezH-Index: 19
view all 9 authors...
Abstract The neural mechanisms underlying response inhibition and related disorders are unclear and controversial for several reasons. First, it is a major challenge to assess the psychological bases of behaviour, and ultimately brain–behaviour relationships, of a function which is precisely intended to suppress overt measurable behaviours. Second, response inhibition is difficult to disentangle from other parallel processes involved in more general aspects of cognitive control. Consequently, di...
6 CitationsSource
#1Antonio P. Strafella (Mental Health Research Institute)H-Index: 21
#2Nicolaas I. Bohnen (UM: University of Michigan)H-Index: 52
Last.Jon StoesslH-Index: 9
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Molecular imaging has proven to be a powerful tool for investigation of parkinsonian disorders. One current challenge is to identify biomarkers of early changes that may predict the clinical trajectory of parkinsonian disorders. Exciting new tracer developments hold the potential for in vivo markers of underlying pathology. Herein, we provide an overview of molecular imaging advances and how these approaches help us to understand PD and atypical parkinsonisms. © 2016 International Parkinson and ...
28 CitationsSource
#1Marion CriaudH-Index: 8
#2Alice PoissonH-Index: 8
Last.Philippe BoulinguezH-Index: 19
view all 11 authors...
Impairment in initiating movements in PD might be related to executive dysfunction associated with abnormal proactive inhibitory control, a pivotal mechanism consisting in gating movement initiation in uncertain contexts.Testing this hypothesis on the basis of direct neural-based evidence.Twelve PD patients on antiparkinsonian medication and fifteen matched healthy controls performed a simple reaction time task during event-related functional MRI scanning.For all subjects, the level of activatio...
8 CitationsSource
#1Marion CriaudH-Index: 8
#2Leigh Christopher (U of T: University of Toronto)H-Index: 10
Last.Antonio P. Strafella (U of T: University of Toronto)H-Index: 33
view all 8 authors...
The insula region is known to be an integrating hub interacting with multiple brain networks involved in cognitive, affective, sensory, and autonomic processes. There is growing evidence suggesting that this region may have an important role in Parkinson's disease (PD). Thus, to investigate the functional organization of the insular cortex and its potential role in parkinsonian features, we used a coordinate-based quantitative meta-analysis approach, the activation likelihood estimation. A total...
15 CitationsSource