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Roma Patel
Maharaja Sayajirao University of Baroda
EndocrinologyGenotypeType 2 diabetesDiabetes mellitusBiology
9Publications
3H-index
22Citations
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Publications 12
Newest
#1Sayantani Pramanik Palit (MSU: Maharaja Sayajirao University of Baroda)H-Index: 2
#2Roma Patel (MSU: Maharaja Sayajirao University of Baroda)H-Index: 3
Last. Rasheedunnisa Begum (MSU: Maharaja Sayajirao University of Baroda)H-Index: 22
view all 9 authors...
Source
#1Sayantani Pramanik Palit (MSU: Maharaja Sayajirao University of Baroda)H-Index: 2
#2Roma Patel (MSU: Maharaja Sayajirao University of Baroda)H-Index: 3
Last. Rasheedunnisa Begum (MSU: Maharaja Sayajirao University of Baroda)H-Index: 22
view all 9 authors...
Adiponectin is a prime determinant of the status of insulin resistance. Association studies between adiponectin (ADIPOQ) gene single nucleotide polymorphisms (SNPs) and metabolic diseases have been reported earlier. However, results are ambiguous due to apparent contradictions. Hence, we investigated (1) the association between ADIPOQ SNPs: −11377C/G, +10211T/G, +45T/G and +276G/T for the risk towards type 2 diabetes (T2D) and, (2) genotype-phenotype association of these SNPs with various bioche...
1 CitationsSource
#1Nirali Rathwa (MSU: Maharaja Sayajirao University of Baroda)H-Index: 2
#2Nishant R. Parmar (MSU: Maharaja Sayajirao University of Baroda)
Last. Rasheedunnisa Begum (MSU: Maharaja Sayajirao University of Baroda)H-Index: 22
view all 6 authors...
Abstract Vaspin, an insulin-sensitizing adipokine, has been associated with type 2 diabetes (T2D). The present study aimed to investigate the distribution of genotypes and high-risk alleles of vaspin genetic variants (rs77060950 G/T and rs2236242 A/T), in Gujarat subpopulation (India). Genomic DNA isolated from PBMCs was used to genotype vaspin polymorphisms by PCR-RFLP and ARMS-PCR from 502 controls and 478 patients. RNA isolated from visceral adipose tissue (VAT) of 22 controls and 20 patients...
1 CitationsSource
#1Nirali Rathwa (MSU: Maharaja Sayajirao University of Baroda)H-Index: 2
#2Roma Patel (MSU: Maharaja Sayajirao University of Baroda)H-Index: 3
Last. Rasheedunnisa Begum (MSU: Maharaja Sayajirao University of Baroda)H-Index: 22
view all 5 authors...
Abstract Resistin, an adipokine, is involved in obesity and Type 2 Diabetes (T2D). The current study evaluates the association between RETN polymorphisms (−638 G/A, −420C/G & −358 G/A) and the risk towards T2D. Controls and T2D patients were enrolled from Gujarat, India. Polymorphisms of RETN were genotyped by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism. For the genotype-phenotype correlation analysis Fasting Blood Glucose (FBG), Body Mass Index (BMI) and plasma lipid prof...
3 CitationsSource
#1Nirali Rathwa (MSU: Maharaja Sayajirao University of Baroda)H-Index: 2
#2Roma Patel (MSU: Maharaja Sayajirao University of Baroda)H-Index: 3
Last. Rasheedunnisa Begum (MSU: Maharaja Sayajirao University of Baroda)H-Index: 22
view all 7 authors...
Abstract Objective Omentin-1, an anti-inflammatory protein, is secreted by the visceral adipose tissue. Altered levels of Omentin-1 are associated with obesity and Type 2 Diabetes (T2D). Although Omentin-1 is implicated in the insulin signaling pathway, the relationship between the genetic variants of Omentin-1 and T2D is not yet explored. The current study evaluates the association of Omentin-1 polymorphisms (rs2274907 A/T and rs1333062 G/T), its transcript and protein levels, and genotype-phen...
1 CitationsSource
#1Roma PatelH-Index: 3
#2Sayantani PramanikH-Index: 1
Last. Rasheedunnisa BegumH-Index: 22
view all 8 authors...
Progressive deterioration of β-cell function and mass is a central parameter to the development of type-1/2 diabetes (T1/2D). Over the last decade, many studies have explored the potential benefits of incretin-based therapies on β-cell preservation and/or regeneration. In this context, DPP-IV inhibitor is known to improve GLP-1 and GIP longevity besides increasing β-cell mass. Melatonin, a pineal hormone is shown to ameliorate oxidative stress and bring about insulin secretion via MT1 receptor a...
Source
#1Roma Patel (MSU: Maharaja Sayajirao University of Baroda)H-Index: 3
#2Sayantani Pramanik Palit (MSU: Maharaja Sayajirao University of Baroda)H-Index: 2
Last. Rasheedunnisa Begum (MSU: Maharaja Sayajirao University of Baroda)H-Index: 22
view all 5 authors...
Summary Background & aim Tumor necrosis factor-α (TNF-α) and its genetic variants are implicated in the development of type 2 diabetes (T2D) as a result of systemic inflammation, dyslipidemia, and insulin resistance. The aim of the present study was to investigate i) single nucleotide polymorphisms (SNPs) of TNF-α and its association with altered TNF-α transcript levels and plasma concentrations ii) free fatty acid (FFA) concentrations as a marker for dyslipidemia and its association with TNF-α ...
1 CitationsSource
#1Nirali RathwaH-Index: 2
#2Roma PatelH-Index: 3
Last. Rasheedunnisa BegumH-Index: 22
view all 6 authors...
Dysfunction of adipocytes and β-cells are crucial in the progression of obesity-related insulin resistance and type 2 diabetes (T2D). γ-Aminobutyric Acid (GABA) is a key neurotransmitter and is secreted by β-cells. It exerts protective and regenerative effects on β-cells. At the metabolic level, Calorie Restriction (CR) has been shown to improve insulin sensitivity, reduces Fasting Blood Glucose (FBG) and increases insulin levels. GABA and CR are speculated to show an additive effect on insulin ...
Source
#1Roma Patel (MSU: Maharaja Sayajirao University of Baroda)H-Index: 3
#2Nirali Rathwa (MSU: Maharaja Sayajirao University of Baroda)H-Index: 2
Last. Rasheedunnisa Begum (MSU: Maharaja Sayajirao University of Baroda)H-Index: 22
view all 5 authors...
Abstract Aim/hypothesis Melatonin is a circadian rhythm regulator and any imbalance in its levels can be related to various metabolic disorders. Melatonin and the genetic variants of Melatonin Receptor 1B (MTNR1B) are reported to be associated with Type 2 Diabetes (T2D) susceptibility. The aim of the present study was to investigate i) plasma melatonin levels ii) Single Nucleotide Polymorphisms (SNPs) of MTNR1B and iii) Genotype-phenotype correlation analysis in T2D patients. Methods Plasma and ...
3 CitationsSource
#1Sayantani Pramanik (MSU: Maharaja Sayajirao University of Baroda)H-Index: 1
#2Nirali Rathwa (MSU: Maharaja Sayajirao University of Baroda)H-Index: 2
Last. Rasheedunnisa Begum (MSU: Maharaja Sayajirao University of Baroda)H-Index: 22
view all 5 authors...
Background: Diabetes has turned into a pandemic disorder that is affecting millions of people worldwide. Industries are aggressively racing and pursuing research towards the discovery of antidiabetic drug and the current global sale of such drugs are ever on the increase. However, in spite of such massive level and expenditure thereof, WHO projects that by 2030, diabetes will rank as the 7th leading cause of mortality. Objective: It is in this context that we have reviewed here the various appro...
2 CitationsSource
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