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Shintaro Yamada
Memorial Sloan Kettering Cancer Center
4Publications
4H-index
192Citations
Publications 4
Newest
#1Shintaro Yamada (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 4
#2Seoyoung Kim (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 4
Last.Scott Keeney (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 51
view all 6 authors...
ABSTRACTThe SPO11-generated DNA double-strand breaks (DSBs) that initiate meiotic recombination occur non-randomly across genomes, but mechanisms shaping their distribution and repair remain incompletely understood. Here, we expand on recent studies of nucleotide-resolution DSB maps in mouse spermatocytes. We find that trimethylation of histone H3 lysine 36 around DSB hotspots is highly correlated, both spatially and quantitatively, with trimethylation of H3 lysine 4, consistent with coordinated...
29 CitationsSource
#1Shintaro Yamada (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 4
#2Seoyoung Kim (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 4
Last.Scott Keeney (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 51
view all 6 authors...
The SPO11-generated DNA double-strand breaks (DSBs) that initiate meiotic recombination occur non-randomly across genomes, but mechanisms shaping their distribution and repair remain incompletely understood. Here, we expand on recent studies of nucleotide-resolution DSB maps in mouse spermatocytes. We find that trimethylation of histone H3 lysine 36 around DSB hotspots is highly correlated, both spatially and quantitatively, with trimethylation of H3 lysine 4, consistent with coordinated formati...
5 CitationsSource
#1Eleni P. Mimitou (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 1
#2Shintaro Yamada (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 4
Last.Scott Keeney (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 51
view all 3 authors...
Meiosis is a specialized double cell division that generates haploid gametes from diploid parent cells. Meiotic recombination between homologous chromosomes ensures the proper segregation of chromosomes to the daughter cells. Mimitou et al. carried out a genome-wide survey of resection of the ends of DNA double strand breaks in yeast. Resection generates single-stranded tails that are vital for meiotic recombination. The Tel1 kinase promoted initiation of resection. Nucleosomes, which normally p...
58 CitationsSource
#1Julian Lange (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 13
#2Shintaro Yamada (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 4
Last.Scott Keeney (Cornell University)H-Index: 51
view all 9 authors...
Summary Heritability and genome stability are shaped by meiotic recombination, which is initiated via hundreds of DNA double-strand breaks (DSBs). The distribution of DSBs throughout the genome is not random, but mechanisms molding this landscape remain poorly understood. Here, we exploit genome-wide maps of mouse DSBs at unprecedented nucleotide resolution to uncover previously invisible spatial features of recombination. At fine scale, we reveal a stereotyped hotspot structure—DSBs occur withi...
100 CitationsSource
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