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Tianhong Zhang
Shenyang Pharmaceutical University
PharmacokineticsBioavailabilityChemistryChromatographyDissolution
56Publications
11H-index
445Citations
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Publications 55
Newest
#1Huixin Li (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Sirun Lu (SPU: Shenyang Pharmaceutical University)
Last. Tianhong Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 11
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AbstractRaloxifene hydrochloride (RH) suffers from low oral bioavailability due to its low water-solubility and first-pass metabolism. Therefore, a novel phospholipid complex of RH (RHPC) and a mat...
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#1Weiping Wang (SPU: Shenyang Pharmaceutical University)
#2Wenshuang Zhang (SPU: Shenyang Pharmaceutical University)
Last. Tianhong Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 11
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AbstractTo improve the aqueous solubility and the oral bioavailability of a poorly water-soluble biologically active pentacyclic triterpenoid, ursolic acid (UA), ursolic acid–phospholipid complex (...
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#1Shuqi Zhang (SPU: Shenyang Pharmaceutical University)
#2Mengna Fang (SPU: Shenyang Pharmaceutical University)
Last. Tianhong Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 11
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AbstractMetronidazole, a BCS class I drug, could be waived based on the BCS principles, thus enabling in vitro dissolution data as a surrogate of BE study. However, the impact of dissolution profil...
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#1Qikun JiangH-Index: 3
#2Jiangnan Zhang (Dalian Medical University)H-Index: 1
Last. Zhonggui HeH-Index: 29
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The cyclic dipeptides generally present lower affinity toward intestinal oligopeptide transporter 1 (PEPT1) than the linear dipeptides. JBP485 (cyclo(l-Hyp-l-Ser)) is a low-affinity substrate of PEPT1 with poor oral bioavailability. However, JBP923 (l-Hyp-l-Ser) is a high-affinity substrate of PEPT1 with high oral absorption. We hypothesize that the bioactivatable pseudo-tripeptidization prodrug strategy is promising to increase the affinity of cyclic dipeptides toward PEPT1. To test our hypothe...
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#1Xiaoting Li (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Yuanhang Yang (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Tianhong Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 11
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A quantitative prediction of human pharmacokinetic (PK) profiles has become an increasing demand for the reduction of the clinical failure of drug formulations. The existing in vitro and in vivo correlation (IVIVC) methodology could achieve this goal, but the development of IVIVC for immediate release (IR) products is challenging. Herein, we report that for certain weakly acidic biopharmaceutical classification system (BCS) class II molecules (piroxicam, PIRO), physiologically based PK (PBPK) mo...
1 CitationsSource
#1Cuiru Liu (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Peiyue Tong (SPU: Shenyang Pharmaceutical University)
Last. Tianhong Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 11
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Abstract Resveratrol (RES), a compound with a variety of pharmacological activities, is reported to be poorly soluble in water and has limited absorption in vivo. And so its application is limited. In this study, a solidified RES phospholipid (PL) complex solid dispersion, containing RES-PL complex (RPC) and Sylysia 350 (S350) together with D-a-tocopheryl polyethylene glycol succinate (Vitamin E TPGS, or simply TPGS) (RPC-SDT) was prepared by simple solvent evaporation. The RPC-SDT was character...
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#1Weiping Wang (SPU: Shenyang Pharmaceutical University)
#2Pengyan Li (SPU: Shenyang Pharmaceutical University)
Last. Tianhong Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 11
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A simple, sensitive, and efficient supercritical fluid chromatography with tandem mass spectrometry method was established for the determination of nimodipine in beagle plasma. One‐step protein precipitation with acetone was used to extract the analytes from the plasma. Nitrendipine was used as the internal standard. The chromatographic separation was achieved on an ACQUITY UPC²™ BEH 2‐EP column, and a gradient elution program was applied at a flow rate of 1.5 mL/min. The detection was carried o...
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#1Xiaoting Li (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Yan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Tianhong Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 11
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Abstract Bioequivalence study is highly prized to piroxicam (PIRO), since its generic products have been widely used worldwide. The present work was undertaken to explore the pharmacokinetic behaviors and bioequivalence of two branded PIRO tablets in beagle dogs using the supercritical fluid chromatography tandem mass spectrometry (SFC-MS/MS) method. Here, a fast evaporation-free liquid-liquid extraction (EF-LLE) method using ethyl acetate was developed for extracting PIRO from beagle dog plasma...
1 CitationsSource
#1Cuiru Liu (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Yingchao Li (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last. Tianhong Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 11
view all 6 authors...
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#1Yingchao Li (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Xingxing Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Tianhong Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 11
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1 CitationsSource
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