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Rubén Cereijo
University of Barcelona
26Publications
11H-index
519Citations
Publications 26
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#1Joan Villarroya (University of Barcelona)H-Index: 17
#2Rubén Cereijo (University of Barcelona)H-Index: 11
Last.Francesc Villarroya (University of Barcelona)H-Index: 40
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#2Laura Campderros (University of Barcelona)H-Index: 2
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#1Laura Campderrós (University of Barcelona)H-Index: 1
#2Ricardo Moure (University of Barcelona)H-Index: 3
Last.Francesc Villarroya (University of Barcelona)H-Index: 40
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#1Rubén Cereijo (University of Barcelona)H-Index: 11
#2Siri D. TaxeråsH-Index: 1
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Introduction miRNAs are small non-coding RNAs, some of which are expressed in adipose tissues, are present in the circulation, and are regulated in obesity. Bariatric surgery (BS) has been proposed to lead to activation of brown adipose tissue, an effect that may be related to beneficial effects of BS on systemic metabolism. Here, we evaluated circulating levels of miR-92a and miR-99b, two miRNAs proposed as biomarkers of brown fat activity, in a cohort of patients with severe obesity before and...
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#1Montserrat Cairó (University of Barcelona)H-Index: 5
#2Laura Campderrós (University of Barcelona)H-Index: 1
Last.Francesc Villarroya (University of Barcelona)H-Index: 40
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Abstract Parkin is an ubiquitin‐E3 ligase that acts as a key component of the cellular machinery for mitophagy. We show here that Parkin expression is reciprocally regulated in brown adipose tissue in relation to thermogenic activity. Thermogenic stimuli repress Parkin gene expression via transcriptional mechanisms that are elicited by noradrenergic and PPARα‐mediated pathways that involve intracellular lipolysis in brown adipocytes. Parkin‐KO mice show over‐activated brown adipose tissue thermo...
2 CitationsSource
#1Joan Villarroya (University of Barcelona)H-Index: 17
#2Rubén Cereijo (University of Barcelona)H-Index: 11
Last.Francesc Villarroya (University of Barcelona)H-Index: 40
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Background. The secretory properties of brown adipose tissue are thought to contribute to the association between active brown fat and a healthy metabolic status. Although a few brown adipokines have been identified, a comprehensive knowledge of the brown adipose tissue secretome is lacking. Methods. Here, to examine the effects of thermogenic activation of brown adipocytes on protein secretion, we used isobaric tags for relative and absolute quantification (iTRAQ) analysis to determine how the ...
1 CitationsSource
#1David Sánchez-Infantes (University of Barcelona)H-Index: 9
#2Rubén Cereijo (University of Barcelona)H-Index: 11
Last.Lourdes Ibáñez (University of Barcelona)H-Index: 57
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Background. Nerve growth factor (NGF) plays a key role in neuroprotection and developmental maturity. We assessed longitudinally the circulating concentrations of NGF in term healthy human newborns and infants as well as their association with prenatal growth and early postnatal feeding patterns. Methods. Circulating NGF and anthropometric measures (weight, length, body mass index, and ponderal index) were assessed longitudinally—at birth and at age 4 months—in 86 term infants born appropriate (...
1 CitationsSource
#1Francesc Villarroya (University of Barcelona)H-Index: 31
#2Rubén Cereijo (University of Barcelona)H-Index: 11
Last.Marta Giralt (University of Barcelona)H-Index: 43
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10 CitationsSource
#1Rubén Cereijo (University of Barcelona)H-Index: 11
#2Aleix Gavaldà-Navarro (University of Barcelona)H-Index: 10
Last.Francesc Villarroya (University of Barcelona)H-Index: 40
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Summary The beneficial effects of brown adipose tissue (BAT) are attributed to its capacity to oxidize metabolites and produce heat, but recent data suggest that secretory properties of BAT may also be involved. Here, we identify the chemokine CXCL14 (C-X-C motif chemokine ligand-14) as a novel regulatory factor secreted by BAT in response to thermogenic activation. We found that the CXCL14 released by brown adipocytes recruited alternatively activated (M2) macrophages. Cxcl14 -null mice exposed...
12 CitationsSource
#1Francesc Villarroya (University of Barcelona)H-Index: 40
#2Rubén Cereijo (University of Barcelona)H-Index: 11
Last.Marta Giralt (University of Barcelona)H-Index: 43
view all 5 authors...
Immune cells were recently found to have an unexpected involvement in controlling the thermogenic activity of brown and beige adipose tissue. Here, we review how macrophages, eosinophils, type 2 innate lymphoid cells, and T lymphocytes are linked to this process. In particular, the recruitment of alternatively activated macrophages and eosinophils is associated with brown fat activation and white fat browning. Conversely, pro-inflammatory immune cell recruitment represses the thermogenic activit...
28 CitationsSource
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