Yong-Jun Li
Guiyang Medical University
High-performance liquid chromatographyChemistryPolygonumChromatographyBiochemistry
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Publications 63
#1Lin ZhengH-Index: 5
#2Yueting LiH-Index: 4
Last. Yong HuangH-Index: 8
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AbstractThe study aimed to compare the pharmacokinetic properties of quercitrin, astragalin, afzelin and taxifolin, four major bioactive components of Polygonum orientale inflorescence extracts, be...
A simple, rapid, and selective ultra-performance liquid chromatography-mass spectrometry (MS)/MS method was established to investigate tissue distribution of 6 polyphenolic compounds of Polygonum o...
#1Jie PanH-Index: 1
#2Yuan LuH-Index: 4
Last. Yonglin WangH-Index: 4
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Hepatocellular carcinoma (HCC) is a malignancy of liver cells. Recent studies have shown that HCC patients often have changes in the activities of transporters and metabolic enzymes, which can cons...
Cardiovascular disease has become one of the main diseases that endanger humans, and oxidative damage plays an important role in this. Shenxiong glucose injection (SGI) is a common clinical treatme...
#1Guangcheng Wang (JSU: Jishou University)H-Index: 10
#2Wenjing LiuH-Index: 1
Last. Zhiyun Peng (Shanghai Ocean University)H-Index: 1
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Abstract A novel series of chalcone derivatives containing diaryl ether moiety (5a-5p) were designed, synthesized and evaluated their anti-tubulin polymerization activities and anticancer activities. Among them, compound 5b with 4-methoxy substitution on right aromatic ring was found to be most active on MCF-7, HepG2 and HCT116 cancer cell lines, with IC50 values of 3.44±0.19, 4.64±0.23, and 6.31±0.27 μM, respectively. In vitro tubulin polymerization assay showed that 5b could effectively inhibi...
2 CitationsSource
#1Mei LiH-Index: 1
Last. Ai-Min WangH-Index: 8
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: This study is to study the absorption properties of different particle size of Gastrodiae Rhizoma powder in rats. In vivo circulation pass perfusion model combined with ultra high performance liquid chromatography-mass spectrometry(UPLC-MS/MS) method was used to determine the cumulative absorption of each component in different particle size of Gastrodiae Rhizoma powder, and the effect of different particle size, different concentrations, different intestine segments and bile on the intestine ...
#1Ying LiH-Index: 1
#2Siying ChenH-Index: 1
Last. Lin ZhengH-Index: 5
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: This work aimed to investigate the intestinal absorption characteristics of Laportea bulbifera extract in normal and rheumatoid arthritis model rats. The contents of neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, rutin, kaempferol-3-O-rutinoside, galuteolin, quercetin and isoquercetin in intestinal absorption solution samples were detected by UPLC-MS/MS with 5.0 g·L~(-1) as the absorption concentration. The cumulative absorption(Q) and absorption rate constant(K_a) were calcula...
#2Yang WangH-Index: 1
Last. Yong-Jun LiH-Index: 8
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Two new compounds, rel-(3S,4aR,10bR)-3-(4′-methoxyphenyl)-8-hydroxy-9-methoxy-4a,5,6,10b-tetrahydro-3H-naphtho[2,1-b]pyran (1), 7-hydroxy- 2-phenylnaphthalene-1-carboxylic acid ethyl ester (2), wer...
Bletilla striata has been widely used as a valuable hemostatic agent for thousands of years due to the high levels of bioactive constituents it contains. Here, we used a sensitive ultrahigh-performance liquid chromatography-tandem mass spectroscopy (UPLC-MS/MS) method for the simultaneous determination of three major active ingredients of the B. striata extract, namely, α-isobutylmalic acid, gymnoside I, and militarine in rat plasma. The three major active ingredients were determined using the m...