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Zhe Wu
Peking University
11Publications
2H-index
9Citations
Publications 11
Newest
#1Zhe Wu (PKU: Peking University)H-Index: 2
#2Jun Xu (PKU: Peking University)H-Index: 1
Last.Yujing Chi (PKU: Peking University)H-Index: 3
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#1Lin Su (PKU: Peking University)
#2Zhe Wu (PKU: Peking University)H-Index: 2
Last.Yulan Liu (PKU: Peking University)H-Index: 7
view all 8 authors...
Abstract Non-alcoholic fatty liver disease (NAFLD) is characterized by altered intestinal microbiota and intestinal immune disorder. Here we investigated the role of mesenteric lymph node (MLN) CD4 + T lymphocytes in NAFLD. In high fat diet (HFD)-fed mice, the percentage ratios of Th1 to Th2 cells and Th17 to Treg cells were imbalanced in MLNs. Co-culture assays showed MLN CD4 + T lymphocytes from HFD-fed mice tended to migrate to the liver and promoted hepatic inflammation. Adoptive transfer of...
#1Yujing Chi (PKU: Peking University)H-Index: 7
#2Yuhong Meng (PKU: Peking University)H-Index: 4
Last.Lu Tie (PKU: Peking University)
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#1Zhe Wu (PKU: Peking University)H-Index: 2
#2Jiang Tan (PKU: Peking University)
Last.Yulan Liu (PKU: Peking University)H-Index: 7
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The mesenteric adipose tissue (MAT) lies between the gut and liver and plays a critical role in hepatic metabolic diseases. In the present study, we found that the MAT was prone to inflammation in ...
#1Jun Xu (PKU: Peking University)H-Index: 1
#2Ning Chen (PKU: Peking University)H-Index: 1
Last.Yulan Liu (PKU: Peking University)H-Index: 7
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Background The aim of this study was to clarify the effect of 5-aminosalicylic acid (5-ASA) treatment on gut bacterial microbiota in patients with ulcerative colitis (UC). Methods A total of 57 UC patients, including 20 untreated and 37 5-ASA-treated, were recruited into an exploration cohort. We endoscopically collected both noninflamed and inflamed mucosal samples from all patients, and compared the gut bacterial profiles using 16S rDNA sequencing. Ten untreated UC patients were then treated w...
#1Feng Zhang (PKU: Peking University)H-Index: 4
#2Wei Wei Jiang (PKU: Peking University)H-Index: 1
Last.Yu Lan Liu (PKU: Peking University)H-Index: 2
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To investigate the alterations and functions of intrahepatic B (IHB) cells in non-alcoholic fatty liver disease (NAFLD) model induced by high-fat diet (HFD).C57BL/6 J mice were fed with HFD for 16 weeks to induce NAFLD. Flow cytometry was used to analyze lymphocytes from liver, spleen and peripheral blood mononuclear cells (PBMC). Real-time polymerase chain reaction and immunofluorescence stain were applied to investigate cytokine expression in the intrahepatic lymphocytes and IHB cells. CD4(+) ...
#1Feng Zhang (PKU: Peking University)H-Index: 4
#2Weiwei Jiang (PKU: Peking University)H-Index: 3
Last.Yu Lan Liu (PKU: Peking University)H-Index: 2
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Aims To investigate the alterations and functions of B cells, especially the intrahepatic B (IHB) cells in high-fat diet (HFD) induced non-alcoholic fatty liver disease (NAFLD). Methods C57BL/6 J mice were induced NAFLD using 16-week HFD. Flow cytometry was used to analyze B cells and T cells in different tissues and co-culture system. Real-time PCR and immunofluorescence staining assays were applied to investigate cytokines expressions in livers, intrahepatic lymphocytes and IHB cells. CD4+ int...
#1Xinyun Qiu (PKU: Peking University)H-Index: 2
#2Xia Li (PKU: Peking University)H-Index: 2
Last.Yulan Liu (PKU: Peking University)H-Index: 7
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The commensal intestinal microbiota plays critical roles in the development of inflammatory bowel diseases (IBD). However, the importance of intestinal fungi and their interactions with bacteria in the pathogenesis of IBD is unclear. In this study, anti-fungal drugs (fluconazole or amphotericin B [AmpB]) were administered to control mice and those treated, acutely (A-DSS) and chronically (C-DSS) with DSS. The severity of colonic inflammation was assessed, and pro-inflammatory cytokine levels in ...
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