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Kirsten Boonstra
Academic Medical Center
36Publications
12H-index
1,077Citations
Publications 36
Newest
#1Elisabeth M. G. de Vries (AMC: Academic Medical Center)H-Index: 10
#2Junfeng Wang (PHRI: Public Health Research Institute)H-Index: 9
Last.C. Y. Ponsioen (AMC: Academic Medical Center)H-Index: 9
view all 10 authors...
Objective Most prognostic models for primary sclerosing cholangitis (PSC) are based on patients referred to tertiary care and may not be applicable for the majority of patients with PSC. The aim of this study was to construct and externally validate a novel, broadly applicable prognostic model for transplant-free survival in PSC, based on a large, predominantly population-based cohort using readily available variables. Design The derivation cohort consisted of 692 patients with PSC from the Neth...
#1Elisabeth M. G. de Vries (UvA: University of Amsterdam)H-Index: 10
#2Junfeng Wang (UvA: University of Amsterdam)H-Index: 9
Last.Cyriel Y. Ponsioen (UvA: University of Amsterdam)H-Index: 42
view all 8 authors...
BACKGROUND: Primary sclerosing cholangitis (PSC) is a slowly progressive liver disease. Reliable biomarkers to predict outcome are urgently needed to serve as surrogate endpoints and/or stratifiers in clinical trials. Reduction of serum alkaline phosphatase (ALP) has been proposed as prognostic surrogate marker in PSC. The aim of this study was to asses if ALP at diagnosis (T0), 1 year later (T1), and percentage change between both time points holds prognostic value, and to determine the optimal...
Reported epidemiology and phenotype distributions vary widely and disease burden of inflammatory bowel disease (IBD) is poorly described. Our aim was to establish these features in a population-based cohort covering 319 976 inhabitants. Furthermore, differences between tertiary referral and peripheral hospital patients were quantified. IBD patients in the adherence area of three peripheral hospitals (2004-2012) were included. Medical and surgical treatment data were obtained. Quality of life and...
#1W J Lammers (Erasmus University Medical Center)H-Index: 1
#2M. Leeman (EUR: Erasmus University Rotterdam)H-Index: 2
Last.Bettina E. HansenH-Index: 62
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BACKGROUND: Criteria assessing biochemical response to ursodeoxycholic acid (UDCA) are established risk stratification tools in primary biliary cholangitis (PBC). We aimed to evaluate to what extent liver tests influenced patient management during a three decade period, and whether this changed over time. METHODS: 851 Dutch PBC patients diagnosed between 1988 and 2012 were reviewed to assess patient management in relation to liver test results during UDCA treatment. To do so, biochemical respons...
#1Kirsten BoonstraH-Index: 12
Last.Cyriel Y. PonsioenH-Index: 42
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BACKGROUND & AIMS: Primary sclerosing cholangitis (PSC) is a progressive cholestatic liver disease of unknown cause, but strongly associated with inflammatory bowel disease (IBD). Potential risk factors triggering PSC have never been studied on a population level. The aim of this study was to evaluate smoking, appendectomy, family history and geographical distribution in a population-based cohort of PSC patients, as compared to IBD control patients and healthy controls (HC). METHODS: For this ca...
Background & Aims Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease. At present, there is no appropriate histologic scoring system available for PSC, evaluating both degree of necroinflammatory activity (grade) and fibrosis (stage). The aim of this study was to assess if three scoring systems, commonly used in different liver diseases could be applied for grading and/or staging of PSC. Methods Sixty-four PSC patients from a Dutch cohort, who underwent diagnostic liver b...
#1W.J. Lammers (Erasmus University Medical Center)H-Index: 2
#2Albert Parés (University of Barcelona)H-Index: 58
Last.Bettina E. Hansen (Erasmus University Medical Center)H-Index: 62
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Background and aims: The epidemiology of inflammatory bowel disease (IBD) is changing. In Europe, recent incidence and prevalence rates are lacking. The primary objective of this study is to update incidence and prevalence figures in a large well-phenotyped populationbased IBD cohort.Methods: All IBD patients living in the adherence area of 2 non-academic hospitals between 20042010 were identified. Patients were searched in 3 independent hospital databases case finding sources. 1378 Possible IBD...
#1Noortje RossenH-Index: 6
#2Susana Fuentes (WUR: Wageningen University and Research Centre)H-Index: 26
Last.Cyriel Y. PonsioenH-Index: 42
view all 8 authors...
Background: Primary sclerosing cholangitis (PSC) is a cholestatic liver disease that is strongly associated with a particular phenotype of inflammatory bowel disease (IBD) with right-sided colonic involvement. In IBD, several studies demonstrated significant aberrancies in the intestinal microbiota in comparison with healthy controls. We aimed to explore the link between IBD and PSC by studying the intestinal mucosa-adherent microbiota in PSC and ulcerative colitis (UC) patients and noninflammat...
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