Kirsten Boonstra
Academic Medical Center
Primary biliary cirrhosisPrimary sclerosing cholangitisPopulationMedicineGastroenterology
What is this?
Publications 38
#1Elisabeth M. G. de Vries (AMC: Academic Medical Center)H-Index: 10
#2Junfeng Wang (PHRI: Public Health Research Institute)H-Index: 9
Last. C. Y. Ponsioen (AMC: Academic Medical Center)H-Index: 9
view all 10 authors...
Objective Most prognostic models for primary sclerosing cholangitis (PSC) are based on patients referred to tertiary care and may not be applicable for the majority of patients with PSC. The aim of this study was to construct and externally validate a novel, broadly applicable prognostic model for transplant-free survival in PSC, based on a large, predominantly population-based cohort using readily available variables. Design The derivation cohort consisted of 692 patients with PSC from the Neth...
14 CitationsSource
#1Elisabeth M. G. de Vries (UvA: University of Amsterdam)H-Index: 10
#2Junfeng Wang (UvA: University of Amsterdam)H-Index: 9
Last. Cyriel Y. Ponsioen (UvA: University of Amsterdam)H-Index: 42
view all 8 authors...
BACKGROUND: Primary sclerosing cholangitis (PSC) is a slowly progressive liver disease. Reliable biomarkers to predict outcome are urgently needed to serve as surrogate endpoints and/or stratifiers in clinical trials. Reduction of serum alkaline phosphatase (ALP) has been proposed as prognostic surrogate marker in PSC. The aim of this study was to asses if ALP at diagnosis (T0), 1 year later (T1), and percentage change between both time points holds prognostic value, and to determine the optimal...
32 CitationsSource
Reported epidemiology and phenotype distributions vary widely and disease burden of inflammatory bowel disease (IBD) is poorly described. Our aim was to establish these features in a population-based cohort covering 319 976 inhabitants. Furthermore, differences between tertiary referral and peripheral hospital patients were quantified. IBD patients in the adherence area of three peripheral hospitals (2004-2012) were included. Medical and surgical treatment data were obtained. Quality of life and...
14 CitationsSource
#1W J Lammers (Erasmus University Medical Center)H-Index: 1
#2M. Leeman (EUR: Erasmus University Rotterdam)H-Index: 2
Last. Bettina E. HansenH-Index: 62
view all 22 authors...
BACKGROUND: Criteria assessing biochemical response to ursodeoxycholic acid (UDCA) are established risk stratification tools in primary biliary cholangitis (PBC). We aimed to evaluate to what extent liver tests influenced patient management during a three decade period, and whether this changed over time. METHODS: 851 Dutch PBC patients diagnosed between 1988 and 2012 were reviewed to assess patient management in relation to liver test results during UDCA treatment. To do so, biochemical respons...
5 Citations
#1Kirsten BoonstraH-Index: 12
Last. Cyriel Y. PonsioenH-Index: 42
view all 13 authors...
BACKGROUND & AIMS: Primary sclerosing cholangitis (PSC) is a progressive cholestatic liver disease of unknown cause, but strongly associated with inflammatory bowel disease (IBD). Potential risk factors triggering PSC have never been studied on a population level. The aim of this study was to evaluate smoking, appendectomy, family history and geographical distribution in a population-based cohort of PSC patients, as compared to IBD control patients and healthy controls (HC). METHODS: For this ca...
10 CitationsSource
#1Ulrich BeuersH-Index: 59
#2Lowiek M. HubersH-Index: 7
Last. Vries de N. KH-Index: 49
view all 9 authors...
IgG4-associated cholangitis (IAC) is an inflammatory disorder of the biliary tract representing a major manifestation of IgG4-related disease (IgG4-RD) often with elevation of serum IgG4 levels, infiltration of IgG4+ plasma cells in the affected tissue and good response to immunosuppressive treatment. Its first description may go back to 150 years ago. The clinical presentation of IAC is often misleading, mimicking other biliary diseases such as primary sclerosing cholangitis (PSC) or cholangioc...
14 CitationsSource
#2Joanne VerheijH-Index: 28
Last. Cyriel Y. PonsioenH-Index: 42
view all 7 authors...
Background & Aims Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease. At present, there is no appropriate histologic scoring system available for PSC, evaluating both degree of necroinflammatory activity (grade) and fibrosis (stage). The aim of this study was to assess if three scoring systems, commonly used in different liver diseases could be applied for grading and/or staging of PSC. Methods Sixty-four PSC patients from a Dutch cohort, who underwent diagnostic liver b...
29 CitationsSource
#2Noortje RossenH-Index: 6
Last. Cyriel Y. PonsioenH-Index: 42
view all 13 authors...
Background and aims: The epidemiology of inflammatory bowel disease (IBD) is changing. In Europe, recent incidence and prevalence rates are lacking. The primary objective of this study is to update incidence and prevalence figures in a large well-phenotyped populationbased IBD cohort.Methods: All IBD patients living in the adherence area of 2 non-academic hospitals between 20042010 were identified. Patients were searched in 3 independent hospital databases case finding sources. 1378 Possible IBD...
4 CitationsSource
#1W.J. Lammers (Erasmus University Medical Center)H-Index: 2
#2Albert Parés (University of Barcelona)H-Index: 58
Last. Bettina E. Hansen (Erasmus University Medical Center)H-Index: 62
view all 30 authors...
1 CitationsSource
#1A. C. Cheung (UHN: University Health Network)H-Index: 3
#2Willem J. Lammers (EUR: Erasmus University Rotterdam)H-Index: 7
Last. H.R. van Buuren (EUR: Erasmus University Rotterdam)H-Index: 39
view all 27 authors...
8 CitationsSource