Miguel J. Stadecker
Tufts University
AntigenImmunologySchistosoma mansoniBiologyImmune system
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Publications 134
#1Parisa Kalantari (Tufts University)H-Index: 1
#2Stephen C. Bunnell (Tufts University)H-Index: 18
Last. Miguel J. Stadecker (Tufts University)H-Index: 39
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Schistosomiasis is a major helminthic disease in which damage to the affected organs is orchestrated by a pathogenic host CD4 T helper (Th) cell-mediated immune response against parasite eggs. In the case of the species Schistosoma mansoni, the resulting granulomatous inflammation and fibrosis takes place in the liver and intestines. The magnitude of disease varies greatly from individual to individual but in a minority of patients there is severe disease and death. S. mansoni infection in a mur...
#1Parisa Kalantari (Tufts University)H-Index: 1
#2Yoelkys Morales (Tufts University)H-Index: 1
Last. Miguel J. Stadecker (Tufts University)H-Index: 39
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Summary The immunopathology caused by schistosome helminths varies greatly in humans and among mouse strains. A severe form of parasite egg-induced hepatic granulomatous inflammation, seen in CBA mice, is driven by Th17 cells stimulated by IL-1β and IL-23 produced by dendritic cells that express CD209a (SIGNR5), a C-type lectin receptor (CLR) related to human DC-SIGN. Here, we show that CD209a-deficient CBA mice display decreased Th17 responses and are protected from severe immunopathology. In v...
5 CitationsSource
#1Andrew C. WangH-Index: 1
#2Laura I. RutitzkyH-Index: 19
Last. Lindsey E. BazzoneH-Index: 6
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#1Holly E. Ponichtera (Tufts University)H-Index: 4
#2Miguel J. Stadecker (Tufts University)H-Index: 39
Abstract Following infection with the trematode helminth Schistosoma mansoni , CBA mice develop severe parasite egg-induced hepatic granulomatous inflammation as well as prominent CD4 + T helper 17 (Th17) cell responses driven by dendritic cell (DC)-derived IL-1β and IL-23. By comparison, C57BL/6 mice develop mild hepatic immunopathology, egg stimulation of DCs does not result in IL-1β and IL-23 production, and Th17 cells fail to develop. To investigate the reasons for strain-specific difference...
6 CitationsSource
#1Patrick M. Smith (Tufts University)H-Index: 7
#2Thomas J. SprouleH-Index: 17
Last. Miguel J. Stadecker (Tufts University)H-Index: 39
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Infection with the helminth Schistosoma mansoni results in hepatointestinal granulomatous inflammation mediated by CD4 T cells directed against parasite eggs. The severity of disease varies greatly in humans and mice; however, the genetic basis of such a heterogenous immune response remains poorly understood. Here we show that, despite their close genetic relationship, C57BL/10SnJ (B10) mice developed significantly more pronounced immunopathology and higher T helper 17 cell responses than C57BL/...
#1Steven A. BogenH-Index: 17
Last. Miguel J. StadeckerH-Index: 39
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#1Holly E. Ponichtera (Tufts University)H-Index: 4
#2Mara G. Shainheit (Tufts University)H-Index: 11
Last. Miguel J. Stadecker (Tufts University)H-Index: 39
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In murine schistosomiasis, immunopathology and cytokine production in response to parasite eggs are uneven and strain dependent. CBA/J (CBA) mice develop severe hepatic granulomatous inflammation associated with prominent Th17 cell responses driven by dendritic cell (DC)-derived IL-1β and IL-23. Such Th17 cells fail to develop in low-pathology C57BL/6 (BL/6) mice, and the reasons for these strain-specific differences in APC reactivity to eggs remain unclear. We show by gene profiling that CBA DC...
18 CitationsSource
#1Holly E. Ponichtera (Tufts University)H-Index: 4
#2Mara G. Shainheit (Tufts University)H-Index: 11
Last. Miguel J. Stadecker (Tufts University)H-Index: 39
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The magnitude of immunopathology and pro-inflammatory cytokine production in murine Schistosoma mansoni infection is strain-dependent. Severe hepatic egg-induced granulomatous inflammation in CBA mice is associated with Th1 and Th17 cytokine responses, whereas BL/6 mice develop milder lesions in a Th2-polarized cytokine environment. Pathogenic Th17 cell responses in CBA mice are dependent on the production of IL-1β and IL-23 by egg-stimulated dendritic cells (DC); by comparison, such Th17 cells ...
#1Rachel Liberman (Tufts University)H-Index: 4
#2Sarah BondH-Index: 5
Last. Michael Forgac (Tufts University)H-Index: 53
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The vacuolar (H+)-ATPases (V-ATPases) are ATP-driven proton pumps composed of a peripheral V1 domain and a membrane-embedded V0 domain. Regulated assembly of V1 and V0 represents an important regulatory mechanism for controlling V-ATPase activity in vivo. Previous work has shown that V-ATPase assembly increases during maturation of bone marrow-derived dendritic cells induced by activation of Toll-like receptors. This increased assembly is essential for antigen processing, which is dependent upon...
27 CitationsSource
#1D. deLeon (Tufts Medical Center)H-Index: 1
#2A. E. Paniz Mondolfi (Tufts Medical Center)H-Index: 1
Last. P. Lizzul (Tufts Medical Center)H-Index: 1
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1 CitationsSource