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Kirill Kovalev
Moscow Institute of Physics and Technology
23Publications
5H-index
98Citations
Publications 23
Newest
#1Kirill KovalevH-Index: 5
#2Dmytro Volkov (Forschungszentrum Jülich)
Last.Alexander Popov (European Synchrotron Radiation Facility)H-Index: 18
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Rhodopsins are the most abundant light-harvesting proteins. A new family of rhodopsins, heliorhodopsins (HeRs), was recently discovered. In opposite to the known rhodopsins their N-termini face the cytoplasm. HeRs structure and function remain unknown. We present structures of two HeR-48C12 states at 1.5 A showing its remarkable difference from all known rhodopsins. Its internal extracellular part is completely hydrophobic, while the cytoplasmic part comprises a cavity (‘active site’), surrounde...
#1Vera V. Nazarenko (MIPT: Moscow Institute of Physics and Technology)
#2V.V. Nazarenko (MIPT: Moscow Institute of Physics and Technology)
Last.A. V. RogachevH-Index: 6
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Light-Oxygen-Voltage (LOV) domains are conserved parts of photoreceptors in plants, bacteria and fungi that bind flavins as chromophores and detect blue light. In the past, LOV domain variants have been developed as fluorescent reporter proteins (called flavin-based fluorescent proteins; FbFPs), which due to their ability to fluoresce under anaerobic conditions, fast folding kinetics and a small size of ∼12–16 kDa are a promising reporter system for quantitative real-time analysis of biological ...
#1Kirill KovalevH-Index: 5
#2Vitaly Polovinkin (CNRS: Centre national de la recherche scientifique)H-Index: 7
Last.Dmitry Bratanov (CNRS: Centre national de la recherche scientifique)H-Index: 1
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Rhodopsins are the most universal biological light-energy transducers and abundant phototrophic mechanisms that evolved on Earth and have a remarkable diversity and potential for biotechnological applications. Recently, the first sodium-pumping rhodopsin KR2 from Krokinobacter eikastus was discovered and characterized. However, the existing structures of KR2 are contradictory, and the mechanism of Na + pumping is not yet understood. Here, we present a structure of the cationic (non H + ) light-d...
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