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Thomas Marian
SwallowingDysphagiaAnesthesiaStrokeMedicine
13Publications
4H-index
68Citations
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Publications 13
Newest
#1Bendix LabeitH-Index: 1
#2Paul MuhleH-Index: 7
Last. Rainer DziewasH-Index: 34
view all 9 authors...
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#2Thomas MarianH-Index: 4
Last. Tobias WarneckeH-Index: 24
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Introduction: Although patients with Parkinson's disease (PD) often suffer from oropharyngeal dysphagia, knowledge about the underlying pathophysiological mechanisms is limited. Substance P (SP) is a localization-independent neurotransmitter of the entire nervous system. Reduced levels of SP were found in saliva of patients with impaired cough reflex and in advanced stages of PD. The aim of the study was to investigate SP in PD patients in order to gain further insights into the underlying patho...
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#2Thomas MarianH-Index: 4
Last. Rainer DziewasH-Index: 34
view all 11 authors...
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#1Paul MuhleH-Index: 7
#2Inga ClausH-Index: 3
Last. Sonja Suntrup-KruegerH-Index: 7
view all 9 authors...
Objective Dysphagia is a frequent and outcome-relevant complication of various neurological disorders, whose treatment options are still limited. Lately, neuromodulatory treatment devices have come into focus to enhance adaptive plasticity in the cortical swallowing network. However, performing neurophysiological and functional imaging studies to investigate these novel neurostimulation techniques for the treatment of neurogenic dysphagia in severely affected patients is difficult. Therefore, ba...
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#1Paul MuhleH-Index: 7
Last. Rainer DziewasH-Index: 34
view all 11 authors...
Introduction Dysphagia is one of the most important and prognostically relevant complications of acute stroke. Pharyngeal Electrical Stimulation (PES) is a treatment device that enhances cortical reorganization for the restoration of swallowing function after cerebral injury. Furthermore, it was shown that PES leads to a temporary increase of Substance P (SP) level in saliva but not serum in healthy adults. The neuropeptide SP likely acts as a neurotransmitter in the pharyngeal mucosa and enhanc...
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#1Thomas MarianH-Index: 4
#2Martin W. Dünser (Johannes Kepler University of Linz)H-Index: 9
Last. Rainer DziewasH-Index: 34
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6 CitationsSource
#1Paul MuhleH-Index: 7
#2Inga ClausH-Index: 3
Last. Sonja Suntrup-KruegerH-Index: 7
view all 9 authors...
Background/Aims: Performing neurophysiological and functional imaging studies in severely affected patients to investigate novel neurostimulation techniques for the treatment of neurogenic dysphagia is difficult. Therefore, basic research needs to be conducted in healthy subjects. Swallowing is a motor function highly dependent on sensory afferent input. Here we propose a virtual peripheral sensory lesion model to mimic pharyngeal sensory impairment, which is known as a major contributor to dysp...
3 CitationsSource
#2Jens MinnerupH-Index: 27
Last. Rainer DziewasH-Index: 34
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1 CitationsSource
#1Thomas MarianH-Index: 4
Last. Rainer DziewasH-Index: 34
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Background: Dysphagia is a frequent and dangerous complication of acute stroke. Apart from a well-timed oropharyngeal muscular contraction pattern, sensory feedback is of utmost importance for safe and efficient swallowing. In the present study, we therefore analyzed the relation between pharyngolaryngeal sensory deficits and post-stroke dysphagia (PSD) severity in a cohort of acute stroke patients with middle cerebral artery (MCA) infarction. Methods: Eighty-four first-ever MCA stroke patients ...
8 CitationsSource
#1Thomas MarianH-Index: 4
Last. Rainer DziewasH-Index: 34
view all 9 authors...
Background: Dysphagia is one of the most dangerous symptoms of acute stroke. Various screening tools have been suggested for the early detection of this condition
1 CitationsSource
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