Kathryn Oliver
University of Alabama at Birmingham
Publications 3
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR), with approximately 90% of patients harboring at least one copy of the disease-associated variant F508del. We utilized a yeast phenomic system to identify genetic modifiers of F508del-CFTR biogenesis, from which ribosomal protein L12 (RPL12/uL11) emerged as a molecular target. In the present study, we investigated mechanism(s) by which suppression of RPL12 rescues F508del protein synthesis and activi...
#1Christine PolteH-Index: 2
#2Daniel WedemeyerH-Index: 1
Last.Zoya IgnatovaH-Index: 27
view all 9 authors...
#1Guido Veit (McGill University)H-Index: 18
#2Kathryn Oliver (UAB: University of Alabama at Birmingham)H-Index: 1
Last.Gergely L. Lukacs (McGill University)H-Index: 51
view all 11 authors...
The most common cystic fibrosis (CF) causing mutation, deletion of phenylalanine 508 (ΔF508 or Phe508del), results in functional expression defect of the CF transmembrane conductance regulator (CFTR) at the apical plasma membrane (PM) of secretory epithelia, which is attributed to the degradation of the misfolded channel at the endoplasmic reticulum (ER). Deletion of phenylalanine 670 (ΔF670) in the yeast oligomycin resistance 1 gene (YOR1, an ABC transporter) of Saccharomyces cerevisiae phenoco...
23 CitationsSource