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Sanjiv Kaul
Oregon Health & Science University
RadiologyPerfusionCardiologyMyocardial infarctionMedicine
414Publications
82H-index
29.8kCitations
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#1Mrinal Yadava (OHSU: Oregon Health & Science University)
#2D. Elizabeth Le (OHSU: Oregon Health & Science University)
Last. Sanjiv Kaul (OHSU: Oregon Health & Science University)H-Index: 82
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Background Therapeutic ultrasound (TUS) has been used to lyse infarct-related coronary artery thrombus. There has been no study examining the effect of TUS specifically on myocardial microthromboemboli seen in acute myocardial infarction and acute coronary syndromes. The aim of this study was to test the hypothesis that TUS improves myocardial blood flow (MBF) and reduces infarct size (IS) in this situation by dissolving myocardial microthrombi. Methods An open-chest canine model of myocardial m...
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#1C. Vaughan Tuohy (OHSU: Oregon Health & Science University)H-Index: 1
#2Sanjiv Kaul (OHSU: Oregon Health & Science University)H-Index: 82
Last. Stephen Heitner (OHSU: Oregon Health & Science University)H-Index: 7
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Hypertrophic cardiomyopathy (HCM) is a heterogeneous genetic disorder most often caused by sarcomeric mutations resulting in left ventricular hypertrophy, fibrosis, hypercontractility, and reduced compliance. It is the most common inherited monogenic cardiac condition, affecting 0.2% of the population. Whereas currently available therapies for HCM have been effective in reducing morbidity, there remain important unmet needs in the treatment of both the obstructive and non-obstructive phenotypes....
2 CitationsSource
#1Shanthi Nagarajan (OHSU: Oregon Health & Science University)H-Index: 6
#2Nabil J. Alkayed (OHSU: Oregon Health & Science University)H-Index: 42
Last. Anthony P. Barnes (OHSU: Oregon Health & Science University)H-Index: 15
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Neurotensin (NTS) is a 13-amino acid neuropeptide with neuroendocrine and vasoactive functions that is widely expressed in the central nervous system and gastrointestinal tract. NTS is sensed by a multiple cell surface proteins including two G protein-coupling receptors (GPCRs): NTS receptors 1 and 2 (NTSR1 and NTSR2). Crystal structures of NTSR1 have successfully elucidated agonist binding within the orthosteric pocket of receptor but have not revealed the full activation state of the receptor....
2 CitationsSource
#1D. Elizabeth Le (OHSU: Oregon Health & Science University)
#1D. Elizabeth Le (OHSU: Oregon Health & Science University)
Last. Sanjiv Kaul (OHSU: Oregon Health & Science University)H-Index: 82
view all 11 authors...
We hypothesized that ranolazine-induced adenosine release is responsible for its beneficial effects in ischemic heart disease. Sixteen open-chest anesthetized dogs with non-critical coronary stenos...
2 CitationsSource
#1Brian Mott (OHSU: Oregon Health & Science University)H-Index: 4
#2Azzdine Ammi (OHSU: Oregon Health & Science University)H-Index: 6
Last. Sanjiv Kaul (OHSU: Oregon Health & Science University)H-Index: 82
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Background Therapeutic ultrasound can reduce infarct size in a model of coronary thrombosis even when sonothrombolysis is ineffective. The aim of this study was to test the hypothesis that ultrasound-induced cardioprotection is mediated by molecules released from the vascular endothelium that increase myocardial blood flow (MBF) and also have direct tissue-salvaging effects. Methods In vivo and in vitro experiments were performed using a 1.05-MHz transducer. For the in vivo experiments 10 contro...
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#1Carmen Methner (OHSU: Oregon Health & Science University)H-Index: 13
#2Anusha Mishra (OHSU: Oregon Health & Science University)H-Index: 11
Last. Jeffrey J. Iliff (OHSU: Oregon Health & Science University)H-Index: 26
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Background: Capillary de-recruitment distal to a coronary stenosis is implicated as the mechanism of reversible perfusion defect and potential myocardial ischemia during coronary hyperemia; however...
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#1Kristina ChenH-Index: 8
#2Sanjiv KaulH-Index: 82
Last. Lars RejnmarkH-Index: 59
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#1Kristina Chen (Shire plc)H-Index: 8
#2Gary C. Curhan (Brigham and Women's Hospital)H-Index: 111
Last. Sanjiv Kaul (OHSU: Oregon Health & Science University)H-Index: 82
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The mechanism by which ranolazine (RAN) alleviates ischemia has not been fully elucidated. We have shown that RAN was associated with an increase in adenosine levels in the absence and presence of ischemia in a canine model. RAN was also associated with improvement in left ventricular function and
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