Match!
Yue Zhang
University of Alabama at Birmingham
Growth hormone receptorEndocrinologyMolecular biologyReceptorBiology
28Publications
15H-index
2,030Citations
What is this?
Publications 26
Newest
#1Yue Zhang (UAB: University of Alabama at Birmingham)H-Index: 15
#2Edward Taub (UAB: University of Alabama at Birmingham)H-Index: 76
Last. David C. Knight (UAB: University of Alabama at Birmingham)H-Index: 25
view all 7 authors...
Assessing brain temperature can provide important information about disease processes (e.g., stroke, trauma) and therapeutic effects (e.g., cerebral hypothermia treatment). Whole-brain magnetic resonance spectroscopic imaging (WB-MRSI) is increasingly used to quantify brain metabolites across the entire brain. However, its feasibility and reliability for estimating brain temperature needs further validation. Therefore, the present study evaluates the reproducibility of WB-MRSI for temperature ma...
Source
#1Ashiya Buckels (UAB: University of Alabama at Birmingham)H-Index: 2
#2Yue Zhang (UAB: University of Alabama at Birmingham)H-Index: 15
Last. Stuart J. Frank (UAB: University of Alabama at Birmingham)H-Index: 45
view all 7 authors...
Abstract Melanoma is the most aggressive skin cancer. Its aggressiveness is most commonly attributed to ERK pathway mutations leading to constitutive signaling. Though initial tumor regression results from targeting this pathway, resistance often emerges. Interestingly, interrogation of the NCI-60 database indicates high growth hormone receptor (GHR) expression in melanoma cell lines. To further characterize melanoma, we tested responsiveness to human growth hormone (GH). GH treatment resulted i...
1 CitationsSource
#1Yue Zhang (UAB: University of Alabama at Birmingham)H-Index: 15
#2Sajina Gc (UAB: University of Alabama at Birmingham)H-Index: 1
Last. Stuart J. Frank (UAB: University of Alabama at Birmingham)H-Index: 45
view all 8 authors...
Abstract Human growth hormone (GH) binds and activates GH receptor (GHR) and prolactin (PRL) receptor (PRLR). LNCaP human prostate cancer cells express only GHR. A soluble fragment of IGF-1 receptor (IGF-1R) extracellular domain (sol IGF-1R) interacts with GHR and blocks GH signaling. We now explore sol IGF-1R's specificity for inhibiting GH signaling via GHR vs. PRLR and test GHR and PRLR extracellular domain inhibition determinants. Although T47D human breast cancer cells express GHR and PRLR,...
1 CitationsSource
#1Yue Zhang (UAB: University of Alabama at Birmingham)H-Index: 15
#2Edward Taub (UAB: University of Alabama at Birmingham)H-Index: 76
Last. David C. Knight (UAB: University of Alabama at Birmingham)H-Index: 25
view all 9 authors...
: To date, single voxel spectroscopy (SVS) is the most commonly used MRS technique. SVS is relatively easy to use and provides automated and immediate access to the resulting spectra. However, it is also limited in spatial coverage. A new and very promising MRS technique allows for whole-brain MR spectroscopic imaging (WB-MRSI) with much improved spatial resolution. Establishing the reproducibility of data obtained using SVS and WB-MRSI is an important first step for using these techniques to ev...
12 CitationsSource
#1Ying Liu (UAB: University of Alabama at Birmingham)H-Index: 4
#2Jing Jiang (UAB: University of Alabama at Birmingham)H-Index: 28
Last. Stuart J. Frank (UAB: University of Alabama at Birmingham)H-Index: 45
view all 6 authors...
: Growth hormone receptor (GHR) and prolactin (PRL) receptor (PRLR) are homologous transmembrane class I cytokine receptors. In humans, GH interacts with GHR homodimers or PRLR homodimers and PRL interacts with only PRLR homodimers to promote signaling. In human breast cancer cells endogenously expressing both receptors, GHR and PRLR specifically coimmunoprecipitate. We previously devised a split luciferase complementation assay to study GHR and PRLR assemblages. In this technique, firefly lucif...
6 CitationsSource
#1Yue Zhang (UAB: University of Alabama at Birmingham)H-Index: 15
#2Xiangdong Wang (SDU: Shandong University)H-Index: 16
Last. Stuart J. Frank (UAB: University of Alabama at Birmingham)H-Index: 45
view all 7 authors...
GH receptor (GHR) binds GH at the cell surface via its extracellular domain and initiates intracellular signal transduction, resulting in important anabolic and metabolic actions. GH signaling is subject to dynamic regulation, which in part is exerted by modulation of cell surface GHR levels. Constitutive and inducible metalloprotease-mediated cleavage of GHR regulate GHR abundance and thereby modulate GH action. We previously demonstrated that GHR proteolysis is catalyzed by the TNF-α convertin...
5 CitationsSource
#1Ying Liu (Stanford University)H-Index: 4
#2Yue Zhang (Stanford University)H-Index: 15
Last. Stuart J. Frank (UAB: University of Alabama at Birmingham)H-Index: 45
view all 9 authors...
GH receptor (GHR) and prolactin (PRL) receptor (PRLR) are homologous transmembrane cytokine receptors. Each prehomodimerizes and ligand binding activates Janus Kinase 2 (JAK2)-signal transducer and activator of transcription (STAT) signaling pathways by inducing conformational changes within receptor homodimers. In humans, GHR is activated by GH, whereas PRLR is activated by both GH and PRL. We previously devised a split luciferase complementation assay, in which 1 receptor is fused to an N-term...
5 CitationsSource
#1Hainan ChenH-Index: 1
#2Jeffrey W. Kleinberger (UMB: University of Maryland, Baltimore)H-Index: 6
Last. Andrew F. StewartH-Index: 41
view all 14 authors...
Pregnancy in rodents is associated with a two- to three-fold increase in beta cell mass, attributable to large increases in beta cell proliferation, complimented by increases in beta cell size, survival and function, mediated mainly by the lactogenic hormones, prolactin (PRL) and placental lactogens (PLs). In humans, however, beta cell mass does not increase as dramatically in pregnancy, and PRL fails to activate proliferation in human islets in vitro. To determine why, we explored the PRL-prola...
31 CitationsSource
#1Ying Liu (UAB: University of Alabama at Birmingham)H-Index: 4
#2Philip A. Berry (UAB: University of Alabama at Birmingham)H-Index: 2
Last. Stuart J. FrankH-Index: 45
view all 10 authors...
The transmembrane GH receptor (GHR) exists at least in part as a preformed homodimer on the cell surface. Structural and biochemical studies suggest that GH binds GHR in a 1:2 stoichiometry to effect acute GHR conformational changes that trigger the activation of the receptor-associated tyrosine kinase, Janus kinase 2 (JAK2), and downstream signaling. Despite information about GHR-GHR association derived from elegant fluorescence resonance energy transfer/bioluminescence resonance energy transfe...
9 CitationsSource
#1Yujun Gan (UAB: University of Alabama at Birmingham)H-Index: 6
#2Ashiya Buckels (UAB: University of Alabama at Birmingham)H-Index: 2
Last. Stuart J. Frank (UAB: University of Alabama at Birmingham)H-Index: 45
view all 8 authors...
GH signaling yields multiple anabolic and metabolic effects. GH binds the transmembrane GH receptor (GHR) to activate the intracellular GHR-associated tyrosine kinase, Janus kinase 2 (JAK2), and downstream signals, including signal transducer and activator of transcription 5 (STAT5) activation and IGF-1 gene expression. Some GH effects are partly mediated by GH-induced IGF-1 via IGF-1 receptor (IGF-1R), a tyrosine kinase receptor. We previously demonstrated in non-human cells that GH causes form...
19 CitationsSource
123