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Archana Singh
Institute of Genomics and Integrative Biology
ChemistryStratum corneumBiochemistryBiologyCell biology
18Publications
7H-index
150Citations
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Publications 28
Newest
#1Ragini GuptaH-Index: 1
#2Jyoti Thakur (Indian Institute of Science Education and Research, Bhopal)H-Index: 1
Last. Aasheesh Srivastava (Indian Institute of Science Education and Research, Bhopal)H-Index: 16
view all 13 authors...
Infections caused by fungal species via their existence as biofilms on medical devices can cause organ damage via candidiasis and candidemia. Different Candida species like Candida albicans can pos...
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#1Aayush GuptaH-Index: 11
#2Aparna Chauhan (Institute of Genomics and Integrative Biology)
Last. Archana Singh (AcSIR: Academy of Scientific and Innovative Research)H-Index: 7
view all 10 authors...
Vitiligo, a common skin disorder, is characterized by the loss of functional melanocytes resulting in the depigmentation of skin. Previous studies have demonstrated molecular and architectural alterations in the epidermal keratinocytes upon loss of melanocytes. The physiological implications of these "altered" keratinocytes are yet not known. We investigated the wound healing efficiency of lesional vs nonlesional skin in 12 subjects with stable nonsegmental vitiligo using histological and ultras...
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#1Desingu Ayyappa Raja (AcSIR: Academy of Scientific and Innovative Research)H-Index: 2
#2Vishvabandhu Gotherwal (AcSIR: Academy of Scientific and Innovative Research)H-Index: 2
Last. Vivek T. Natarajan (AcSIR: Academy of Scientific and Innovative Research)H-Index: 9
view all 13 authors...
Tanning response and melanocyte differentiation are mediated by the central transcription factor MITF. This involves the rapid and selective induction of melanocyte maturation genes, while concomitantly the expression of other effector genes is maintained. In this study, using cell-based and zebrafish model systems, we report on a pH-mediated feed-forward mechanism of epigenetic regulation that enables selective amplification of the melanocyte maturation program. We demonstrate that MITF activat...
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Neuronal ceroid-lipofuscinosis (NCL) is a heterogeneous and rare lysosomal storage disorder characterized by the accumulation of autofluorescent materials—ceroid and lipofuscin—in the cytoplasm.1 It is manifested as a progressive destruction of neuronal cells resulting in brain atrophy, loss of vision, and other neurodegenerative phenotypes.1 Over 446 mutations in different genes have been cataloged in the NCL mutation database ([ucl.ac.uk/ncl/mutation][1]). The overlapping phenotypes and involv...
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#1Richa Virmani (DU: University of Delhi)H-Index: 5
#2Andaleeb Sajid (Institute of Genomics and Integrative Biology)H-Index: 7
Last. Yogendra Singh (DU: University of Delhi)H-Index: 31
view all 17 authors...
3 CitationsSource
#1Kavita Yadav (Manipal University)H-Index: 3
#2Prabhu Srinivas Yavvari (Indian Institute of Science Education and Research, Bhopal)H-Index: 5
Last. Avinash BajajH-Index: 22
view all 15 authors...
A major impediment to develop effective antimicrobials against Gram-negative bacteria like Salmonella is the ability of the bacteria to develop resistance against existing antibiotics and inability of the antimicrobials to clear the intracellular bacteria residing in the gastrointestinal tract. As critical balance of charge and hydrophobicity is required for effective membrane-targeting antimicrobials without causing any toxicity to mammalian cells, herein we report the synthesis and antibacteri...
1 CitationsSource
#1Kavita Yadav (Manipal University)H-Index: 3
#2Sandeep Kumar (Manipal University)H-Index: 4
Last. Avinash BajajH-Index: 22
view all 18 authors...
The presence of lipopolysaccharide and emergence of drug resistance make the treatment of Gram-negative bacterial infections highly challenging. Herein, we present the synthesis and antibacterial activities of cholic acid–peptide conjugates (CAPs), demonstrating that valine–glycine dipeptide-derived CAP 3 is the most effective antimicrobial. Molecular dynamics simulations and structural analysis revealed that a precise intramolecular network of CAP 3 is maintained in the form of evolving edges, ...
2 CitationsSource
#1Vivek T. Natarajan (CSIR: Council of Scientific and Industrial Research)H-Index: 9
#2Desingu Ayyappa Raja (Institute of Genomics and Integrative Biology)H-Index: 2
Last. Rajesh S. GokhaleH-Index: 31
view all 9 authors...
Tanning response and melanocyte differentiation are mediated by the central transcription factor MITF. Enigmatically, these involve rapid and selective induction of melanocyte maturation genes, while concomitantly maintaining the expression of other effectors. In this study using cell-based and zebrafish model systems, we elucidate a pH mediated feed-forward mechanism of epigenetic regulation that enables selective amplification of melanocyte maturation program. We demonstrate that MITF activati...
Source
#1Anusha Aditya (AcSIR: Academy of Scientific and Innovative Research)H-Index: 2
#2Sabyasachi Chattopadhyay (Institute of Genomics and Integrative Biology)H-Index: 2
Last. Munia Ganguli (AcSIR: Academy of Scientific and Innovative Research)H-Index: 14
view all 10 authors...
ZnO nanoparticles of different sizes were functionalized with an amphipathic peptide, and its effect on nanoparticle stabilization and UV photoprotective activity was studied in this article. The peptide-modified nanoparticles exhibited lower aggregation, significant reduction in Zn2+ leaching in vitro and even inside the cells for smaller particle sizes, reduced photocatalytic activity, and reduced cellular toxicity under UV-B treated conditions. In addition, the peptide-modified 60 nm ZnO nano...
2 CitationsSource
#1Ankur Bothra (Institute of Genomics and Integrative Biology)H-Index: 3
#2Prabhakar Arumugam (Institute of Genomics and Integrative Biology)H-Index: 2
Last. Vivek Rao (AcSIR: Academy of Scientific and Innovative Research)H-Index: 3
view all 12 authors...
The mycobacterial cell wall is a chemically complex array of molecular entities that dictate the pathogenesis of Mycobacterium tuberculosis. Biosynthesis and maintenance of this dynamic entity in mycobacterial physiology is still poorly understood. Here we demonstrate a requirement for M. tuberculosis MmpL11 in the maintenance of the cell wall architecture and stability in response to surface stress. In the presence of a detergent like Tyloxapol, a mmpL11 deletion mutant suffered from a severe g...
3 CitationsSource
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