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Archana Singh
Institute of Genomics and Integrative Biology
23Publications
7H-index
187Citations
Publications 23
Newest
#1Kavita Yadav (Manipal University)H-Index: 2
#2Prabhu Srinivas Yavvari (Indian Institute of Science Education and Research, Bhopal)H-Index: 5
Last.Priyanka Sharma (AIIMS: All India Institute of Medical Sciences)H-Index: 2
view all 15 authors...
A major impediment to developing effective antimicrobials against Gram-negative bacteria like Salmonella is the ability of the bacteria to develop resistance against existing antibiotics and the inability of the antimicrobials to clear the intracellular bacteria residing in the gastrointestinal tract. As the critical balance of charge and hydrophobicity is required for effective membrane-targeting antimicrobials without causing any toxicity to mammalian cells, herein we report the synthesis and ...
#1Kavita Yadav (Manipal University)H-Index: 2
#2Sandeep Kumar (Manipal University)H-Index: 4
view all 18 authors...
The presence of lipopolysaccharide and emergence of drug resistance make the treatment of Gram-negative bacterial infections highly challenging. Herein, we present the synthesis and antibacterial activities of cholic acid–peptide conjugates (CAPs), demonstrating that valine–glycine dipeptide-derived CAP 3 is the most effective antimicrobial. Molecular dynamics simulations and structural analysis revealed that a precise intramolecular network of CAP 3 is maintained in the form of evolving edges, ...
#1Anusha Aditya (AcSIR: Academy of Scientific and Innovative Research)H-Index: 2
#2Sabyasachi Chattopadhyay (Institute of Genomics and Integrative Biology)H-Index: 2
Last.Munia Ganguli (AcSIR: Academy of Scientific and Innovative Research)H-Index: 13
view all 10 authors...
ZnO nanoparticles of different sizes were functionalized with an amphipathic peptide, and its effect on nanoparticle stabilization and UV photoprotective activity was studied in this article. The peptide-modified nanoparticles exhibited lower aggregation, significant reduction in Zn2+ leaching in vitro and even inside the cells for smaller particle sizes, reduced photocatalytic activity, and reduced cellular toxicity under UV-B treated conditions. In addition, the peptide-modified 60 nm ZnO nano...
#1Ankur Bothra (Institute of Genomics and Integrative Biology)H-Index: 2
#2Prabhakar Arumugam (Institute of Genomics and Integrative Biology)H-Index: 2
Last.Rajesh S. Gokhale (AcSIR: Academy of Scientific and Innovative Research)H-Index: 27
view all 12 authors...
The mycobacterial cell wall is a chemically complex array of molecular entities that dictate the pathogenesis of Mycobacterium tuberculosis. Biosynthesis and maintenance of this dynamic entity in mycobacterial physiology is still poorly understood. Here we demonstrate a requirement for M. tuberculosis MmpL11 in the maintenance of the cell wall architecture and stability in response to surface stress. In the presence of a detergent like Tyloxapol, a mmpL11 deletion mutant suffered from a severe g...
The cell wall of Mycobacterium tuberculosis (Mtb) is a complex structure that protects the pathogen in hostile environments. Peptidoglycan (PG), which helps determine the morphology of the cell envelope, undergoes substantial remodeling under stress. This meshwork of linear chains of sugars, crosslinked through attached peptides, is generated through the sequential action of enzymes termed transglycosylases and transpeptidases. The Mtb genome encodes two classical transglycosylases and four tran...
#1Archana Singh (Institute of Genomics and Integrative Biology)H-Index: 7
#2Vishvabandhu Gotherwal (AcSIR: Academy of Scientific and Innovative Research)H-Index: 2
Last.Aayush GuptaH-Index: 10
view all 21 authors...
In vitiligo, chronic loss of melanocytes and consequent absence of melanin from the epidermis presents a challenge for long-term tissue maintenance. The stable vitiligo patches are known to attain an irreversible depigmented state. However, the molecular and cellular processes resulting in this remodeled tissue homeostasis is unclear. To investigate the complex interplay of inductive signals and cell intrinsic factors that support the new acquired state, we compared the matched lesional and non-...
#1Amrita Ramkumar (Institute of Genomics and Integrative Biology)H-Index: 2
#2Divya Murthy (Institute of Genomics and Integrative Biology)H-Index: 4
Last.Sridhar Sivasubbu (Institute of Genomics and Integrative Biology)H-Index: 22
view all 13 authors...
ABSTRACTMacroautophagy/autophagy is a dynamic and inducible catabolic process that responds to a variety of hormonal and environmental cues. Recent studies highlight the interplay of this central pathway in a variety of pathophysiological diseases. Although defective autophagy is implicated in melanocyte proliferation and pigmentary disorders, the mechanistic relationship between the 2 pathways has not been elucidated. In this study, we show that autophagic proteins LC3B and ATG4B mediate melano...
#1Shilpa JamwalH-Index: 5
#2Parul MehrotraH-Index: 2
Last.Kanury V. S. RaoH-Index: 23
view all 6 authors...
Survival of Mycobacterium tuberculosis (Mtb) within the host macrophage is mediated through pathogen-dependent inhibition of phagosome-lysosome fusion, which enables bacteria to persist within the immature phagosomal compartment. By employing ultrastructural examination of different field isolates supported by biochemical analysis, we found that some of the Mtb strains were in fact poorly adapted for subsistence within endocytic vesicles of infected macrophages. Instead, through a mechanism invo...
#1Vijay Pal Singh (Institute of Genomics and Integrative Biology)H-Index: 17
#2Rajender K. Motiani (Institute of Genomics and Integrative Biology)H-Index: 18
Last.Rajesh S. Gokhale (AcSIR: Academy of Scientific and Innovative Research)H-Index: 27
view all 10 authors...
Vitiligo is a multifactorial acquired depigmenting disorder. Recent insights into the molecular mechanisms driving the gradual destruction of melanocytes in vitiligo will likely lead to the discovery of novel therapies, which need to be evaluated in animal models that closely recapitulate the pathogenesis of human vitiligo. In humans, vitiligo is characterized by a spontaneous loss of functional melanocytes from the epidermis, but most animal models of vitiligo are either inducible or geneticall...
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