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Sean Stevens
Somatic hypermutationAntibodyAllelic exclusionImmunoglobulin light chainImmunoglobulin heavy chain
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Antibodies in humans and mice typically consist of two identical immunoglobulin heavy chains paired with two identical light chains, either kappa (Igκ) or lambda (Igλ), joined by disulfide bonds. B cells normally produce antibodies derived from a single heavy and a single light chain that recognize a single antigen, and thus are monospecific. The germ line Igκ and Igλ loci are complex units that coordinate ordered, cell- and stage-specific functions including chromatin structure and epigenetic s...
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