Mirim Jin
Gachon University
Immunoglobulin EMolecular biologyImmunologyBiochemistryBiology
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Publications 62
#2Mirim JinH-Index: 15
Last. YoungJoo LeeH-Index: 17
view all 4 authors...
Tumor necrosis factor-alpha (TNF-α) is a well-known pro-inflammatory cytokine responsible for the modulation of the immune system. TNF-α plays a critical role in almost every type of inflammatory disorder, including central nervous system (CNS) diseases. Although TNF-α is a well-studied component of inflammatory responses, its functioning in diverse cell types is still unclear. TNF-α functions through its two main receptors: tumor necrosis factor receptor 1 and 2 (TNFR1, TNFR2), also known as p5...
Tryptophanyl tRNA synthetase (WRS) is an essential enzyme as it catalyzes the ligation of tryptophan to its cognate tRNA during translation. Interestingly, mammalian WRS has evolved to acquire domains or motifs for novel functions beyond protein synthesis; WRS can also further expand its functions via alternative splicing and proteolytic cleavage. WRS is localized not only to the nucleus but also to the extracellular space, playing a key role in innate immunity, angiogenesis, and IFN-γ signaling...
2 CitationsSource
Functional dyspepsia (FD) is the most common functional gastrointestinal disorder (FGID). FD is characterized by bothersome symptoms such as postprandial fullness, early satiety, and epigastric pain or burning sensations in the upper abdomen. The complexity and heterogeneity of FD pathophysiology, which involves multiple mechanisms, make both treatment and new drug development for FD difficult. Current medicines for FD targeting a single pathway have failed to show satisfactory efficacy and safe...
#1Mirim Jin (Gachon University)H-Index: 15
#2Juhan YoonH-Index: 1
#1Hyun-Cheol LeeH-Index: 5
#2Eun-Seo LeeH-Index: 2
Last. Jong-Soo LeeH-Index: 22
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1 CitationsSource
#1Eunho ChunH-Index: 1
Last. Mirim JinH-Index: 15
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Irritable bowel syndrome (IBS) is a common gastrointestinal disorder manifesting as unexplained abdominal pain and bowel habit changes. The pathogenesis of post-infectious IBS is associated with gut–brain axis dysfunction, including low-grade colonic inflammation and anxiety-related long-term brain changes. This study analyzed the efficacy of a standardized extract of Dolichos lablab L. extract (DL), a bean species, in an IBS mouse model resembling post-infectious, diarrhea-dominant IBS. Using a...
#1Kyohee Cho (Gachon University)H-Index: 2
#2Amna Parveen (Gachon University)H-Index: 3
Last. Sun Yeou Kim (Gachon University)H-Index: 36
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Abstract Purpose Pyrus ussuriensis Maxim. has been reported to treat the fever, cough, asthma, and chronic skin disease in Korean Medicine. However, there is no scientific evidence for the use of Pyrus ussuriensis Maxim. Leaves (PUL) extract or its mechanism of action in atopic dermatitis (AD). This study was performed to find the potential therapeutic effects of PUL on the progression of AD using in vitro and in vivo experimental models. Methods We examined the effects of PUL on the production ...
2 CitationsSource
#1Se-Ra Park (Gachon University)H-Index: 5
#2Ara Cho (Gachon University)H-Index: 1
Last. In-Sun Hong (Gachon University)H-Index: 12
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Gonadotropin-releasing hormone (GnRH) stimulates the synthesis and release of gonadotropins, which induce estrogen production and subsequent ovulation. Therefore, long-term GnRH exposure to regulate ovarian hyperstimulation is recognized as the gold standard for most in vitro fertilization (IVF) strategies. However, one of the most disappointing aspects of current IVF technology is relatively low rate (between 35 and 50%) of positive pregnancy outcomes, and the major reason for this high cancell...
#1Na-Hee Lee (SKKU: Sungkyunkwan University)H-Index: 3
#2Ara Cho (Gachon University)H-Index: 1
Last. In-Sun Hong (Gachon University)H-Index: 12
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The toxicological evaluation of potential drug candidates is very important in the preclinical phase of drug development. Toxic materials may cause serious decline in stem cell function and loss of stemness. Indeed, we found that toxic exposure more profoundly suppressed the growth of stem cells than terminally differentiated fibroblasts. Importantly, toxic exposure suppressed stem cell migration and multi-lineage differentiation potential in vitro and in vivo. Moreover, early-response genes inv...
4 CitationsSource