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Lars Sottrup-Jensen
Aarhus University
Molecular biologyChemistryMacroglobulinBiochemistryBiology
171Publications
51H-index
7,812Citations
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Publications 171
Newest
#1Torben E. PetersenH-Index: 50
Last. Staffan MagnussonH-Index: 26
view all 7 authors...
Approximately one-half of the amino acid se- quence (911 amino acid residues out of 1,880 expected) for bovine plasma fibronectin (cold-insoluble globulin) has been determined. Three types of internal homology were identified, showing that a number of partial gene duplications (multiplications) have oc- curred during the evolution of this protein. Digestion of fibro- nectin with plasmin results in major fragments with molecular masses of 29, 170, 23, and 6 kilodaltons (kDal). The NH2-terminal 29...
European, Spanish, and Catalan Agencies. Grant Number: FP7-HEALTH-2010-261460; GumsJ RAPID. Grant Number: FP7-HEALTH-2012-306029-2; TRIGGER. Grant Numbers: BFU2012-32862, CSD2006-00015; La Marato de TV3. Grant Numbers: 2009-100732, 2009SGR1036; ESRF
5 CitationsSource
#1Lars Sottrup-Jensen (AU: Aarhus University)H-Index: 51
#2Gregers R. Andersen (AU: Aarhus University)H-Index: 36
4 CitationsSource
#1Gregers R. Andersen (AU: Aarhus University)H-Index: 36
#2Rune T. Kidmose (AU: Aarhus University)H-Index: 6
Last. Péter Gál (MTA: Hungarian Academy of Sciences)H-Index: 32
view all 10 authors...
2 CitationsSource
An essential aspect of innate immunity is recognition of molecular patterns on the surface of pathogens or altered self through the lectin and classical pathways, two of the three well-established activation pathways of the complement system. This recognition causes activation of the MASP-2 or the C1s serine proteases followed by cleavage of the protein C4. Here we present the crystal structures of the 203-kDa human C4 and the 245-kDa C4⋅MASP-2 substrate⋅enzyme complex. When C4 binds to MASP-2, ...
68 CitationsSource
#1A. Marrero (CSIC: Spanish National Research Council)H-Index: 8
#2Stéphane Duquerroy (University of Paris-Sud)H-Index: 21
Last. F. Xavier Gomis-Rüth (CSIC: Spanish National Research Council)H-Index: 31
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1 CitationsSource
#1A. Marrero (CSIC: Spanish National Research Council)H-Index: 8
#2Stéphane Duquerroy (University of Paris-Sud)H-Index: 21
Last. F. Xavier Gomis-Rüth (CSIC: Spanish National Research Council)H-Index: 31
view all 9 authors...
Source
#1A. Marrero (CSIC: Spanish National Research Council)H-Index: 8
#2Stéphane Duquerroy (University of Paris-Sud)H-Index: 21
Last. F. Xavier Gomis-Rüth (CSIC: Spanish National Research Council)H-Index: 31
view all 9 authors...
61 CitationsSource
#1A. MarreroH-Index: 8
#2Stéphane DuquerroyH-Index: 21
Last. Franz-Xaver Gomis-RüthH-Index: 21
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Source
#1N.S. Laursen (AU: Aarhus University)H-Index: 6
#2Kasper R. Andersen (AU: Aarhus University)H-Index: 15
Last. Gregers R. Andersen (AU: Aarhus University)H-Index: 36
view all 6 authors...
Complement acts as a danger-sensing system in the innate immune system, and its activation initiates a strong inflammatory response and cleavage of the proteins C3 and C5 by proteolytic enzymes, the convertases. These contain a non-catalytic substrate contacting subunit (C3b or C4b) in complex with a protease subunit (Bb or C2a). We determined the crystal structures of the C3b homologue cobra venom factor (CVF) in complex with C5, and in complex with C5 and the inhibitor SSL7 at 4.3 A resolution...
55 CitationsSource
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