Match!
Jakub Rok
Medical University of Silesia
20Publications
7H-index
97Citations
Publications 21
Newest
#1Michalina Respondek (Medical University of Silesia)H-Index: 2
#2Artur Beberok (Medical University of Silesia)H-Index: 9
Last.Dorota Wrześniok (Medical University of Silesia)H-Index: 13
view all 5 authors...
Source
#1Zuzanna RzepkaH-Index: 3
#2Jakub RokH-Index: 7
Last.Dorota WrześniokH-Index: 13
view all 7 authors...
Cobalamin deficiency is an important health problem. The major non-hematological symptoms of hypocobalaminemia are nervous system disorders, but the molecular and cellular mechanisms underlying this phenomenon have not yet been fully explained. Increasing scientific evidence is stressing the pivotal role of astrocyte dysfunction in the pathogenesis of a wide range of neurological disorders. In light of the above, the aim of this study was to develop an in vitro model of cobalamin deficiency by o...
Source
#1Michalina Respondek (Medical University of Silesia)H-Index: 2
#2Artur Beberok (Medical University of Silesia)H-Index: 9
Last.Dorota Wrześniok (Medical University of Silesia)H-Index: 13
view all 5 authors...
Mcl-1 is a potent antiapoptotic protein and amplifies frequently in many human cancer. Currently, it is considered that the extensively expressed of Mcl-1 protein in melanoma cells is associated with rapid tumor progression, poor prognosis and low chemosensitivity. Therefore, the antiapoptotic protein Mcl-1 could be considered as a potential target for malignant melanoma treatment. The aim of this study was to assess the effect of MIM1 a specific low molecular Mcl-1 protein inhibitor and mixture...
Source
#1Jakub Rok (Medical University of Silesia)H-Index: 7
#2Zuzanna Rzepka (Medical University of Silesia)H-Index: 2
Last.Dorota Wrześniok (Medical University of Silesia)H-Index: 13
view all 5 authors...
Abstract Tetracyclines belong to antimicrobial classes with the highest consumption in veterinary medicine and agriculture, which leads to the contamination of the environment and food products, as well as to antibiotic resistance and adverse drug reactions. Chloro-derivatives of tetracyclines are thought to be relatively more phototoxic than others and belong to the most frequently cited drugs as photosensitizers. Melanins are heterogenous biopolymers determining skin, hair and eye colour. They...
Source
#1Artur Beberok (Medical University of Silesia)H-Index: 9
#2Zuzanna Rzepka (Medical University of Silesia)H-Index: 2
Last.Dorota Wrześniok (Medical University of Silesia)H-Index: 13
view all 6 authors...
Abstract Fluoroquinolones were shown to be cytotoxic towards various cancer cell lines, thus representing a potentially important source of new anticancer agents. The aim of the present study was to examine the effect of moxifloxacin on cell viability, redox balance and apoptosis in both amelanotic – C32 and melanotic – COLO829 melanoma cells. Herein, we found that moxifloxacin decreases the viability of C32 and COLO829 cells in concentration- and time-dependent manner. The EC50 values were foun...
1 CitationsSource
#1Michalina Respondek (Medical University of Silesia)H-Index: 2
#2Artur Beberok (Medical University of Silesia)H-Index: 9
Last.Ewa Buszman (Medical University of Silesia)H-Index: 18
view all 6 authors...
Abstract Glioblastoma multiforme (GBM) is the most common and high aggressive malignant brain tumor. Despite evolving oncology treatment and novel chemotherapeutic agents the median survival of patients diagnosed with GBM is only 12–15 months. This grim fact highlights necessity to identify new drugs that could improve the effectiveness of GBM patients treatment. MIM1 is a specific low molecular Mcl-1 protein inhibitor able to induce Mcl-1-dependent cancer cells death. The aim of this study was ...
1 CitationsSource
Vitamin B12 deficiency causes significant changes in cellular metabolism leading to various clinical symptoms, such as hematological, psychiatric, and neurological disorders. We hypothesize that skin pigmentation disorders may be a diagnostically important manifestation of vitamin B12 deficiency, however the cellular and molecular mechanisms underlying these effects remain unknown. The aim of this study was to examine the effect of vitamin B12 deficiency on melanocytes homeostasis. Hypocobalamin...
2 CitationsSource
#1Artur Beberok (Medical University of Silesia)H-Index: 9
#2Zuzanna Rzepka (Medical University of Silesia)H-Index: 2
Last.Dorota Wrześniok (Medical University of Silesia)H-Index: 13
view all 6 authors...
Abstract Fluoroquinolones are a known synthetic group of antibiotics that have been the subject of many research interests. This class of antibiotics was shown to be cytotoxic towards various cancer cell lines, thus representing a potentially important source of new anticancer agents. The present study was designed to examine the effect of ciprofloxacin and moxifloxacin on cell viability, redox balance and apoptosis in U87MG glioblastoma cells. Herein, we found that both fluoroquinolones decreas...
2 CitationsSource
#1Jakub Rok (Medical University of Silesia)H-Index: 7
#2Dorota Wrześniok (Medical University of Silesia)H-Index: 13
Last.Ewa Buszman (Medical University of Silesia)H-Index: 18
view all 6 authors...
Abstract Oxytetracycline is a broad-spectrum antibiotic, used in dermatology and veterinary medicine. Like other tetracyclines, it may evoke skin phototoxic reactions related to generation of reactive oxygen species (ROS). Melanins are biopolymers synthesised in melanocytes – highly specialised cells, localised in the basal layer of epidermis. Production of melanin is a defence mechanism against harmful effects of UV radiation, ROS and many chemical substances, including drugs. In the present st...
2 CitationsSource
#1Artur Beberok (Medical University of Silesia)H-Index: 9
#2Dorota Wrześniok (Medical University of Silesia)H-Index: 13
Last.Ewa Buszman (Medical University of Silesia)H-Index: 18
view all 6 authors...
11 CitationsSource
123