Match!
Randolph J. Nudo
University of Kansas
NeuroscienceMotor cortexMicrostimulationPrimary motor cortexStroke
147Publications
48H-index
12.4kCitations
What is this?
Publications 146
Newest
#1Kevin C. Elliott (KU: University of Kansas)H-Index: 1
#2Jordan A Borrell (KU: University of Kansas)H-Index: 2
Last. Randolph J. Nudo (KU: University of Kansas)H-Index: 48
view all 4 authors...
Cortical injuries (e.g. strokes or traumatic brain injuries) can create a host of secondary events that further impair the brain9s sensory, motor, or cognitive capabilities. Here, we attempted to isolate the acute effects of the primary injury, i.e., the loss of cortical activity, on rodent motor cortex (caudal forelimb area, CFA) without the secondary effects that arise from damage to cortical tissue. We then observed the effects of this loss of activity on the rodent premotor cortex (rostral f...
Source
#1David W. McNeal (KU: University of Kansas)H-Index: 12
#2Scott Barbay (KU: University of Kansas)H-Index: 24
Last. Randolph J. Nudo (KU: University of Kansas)H-Index: 48
view all 6 authors...
Brain injury affecting the isocortical frontal cortex is a common pathological occurrence. Many patients report severe deficits to functions of daily living. However, there is a variable degree of motor recovery that occurs with some individuals recovering astounding degrees of motor recovery while others have not. This variability has led researchers into investigating the possible mechanisms for this variability. Recently, several non-human primate studies have shed light on the possibility of...
Source
#1Jordan A Borrell (KU: University of Kansas)H-Index: 2
#2Dora Krizsan-Agbas (KU: University of Kansas)H-Index: 9
Last. Shawn B. Frost (KU: University of Kansas)H-Index: 19
view all 4 authors...
Objective. The purpose of this study was to determine the effects of spinal cord injury (SCI) on spike activity evoked in the hindlimb spinal cord of the rat from cortical electrical stimulation. Approach. Adult, male, Sprague Dawley rats were randomly assigned to a Healthy or SCI group. SCI rats were given a 175 kDyn dorsal midline contusion injury at the level of the T8 vertebrae. At four weeks post-SCI, intracortical microstimulation (ICMS) was delivered at several sites in the hindlimb motor...
1 CitationsSource
#1Jordan A BorrellH-Index: 2
#2Dora Krizsan-AgbasH-Index: 9
Last. Shawn B. FrostH-Index: 19
view all 4 authors...
Objective: The purpose of this study was to assess the ability of intraspinal microstimulation, triggered by action potentials (spikes) recorded in motor cortex, to alter synaptic efficacy in descending motor pathways in an anesthetized rat model of spinal cord injury. Approach. Experiments were carried out in adult, male, Sprague Dawley rats with a moderate contusion injury at T8. Four weeks after SCI, and under ketamine/xylazine anesthesia, fine wire electromyographic (EMG) electrodes were imp...
Source
#1Andrea Pack (Emory University)H-Index: 2
#2Maxwell D. Murphy (KU: University of Kansas)H-Index: 2
Last. David J. Guggenmos (KU: University of Kansas)H-Index: 9
view all 5 authors...
Acquired injuries to primary motor cortex (M1) contribute to motor impairment and disability. Functional recovery is predicated on the reorganization of spared areas, which has been demonstrated through cortical motor map representations and neuroanatomical projection and termination patterns. The purpose of this study was to understand how neurophysiological outputs of spared motor areas relate to motor recovery of a skilled reach task following an ischemic infarct to M1. We examined changes in...
Source
#1Edward T. R. UrbanH-Index: 2
#2Randolph J. Nudo (KU: University of Kansas)H-Index: 48
Last. David J. Guggenmos (KU: University of Kansas)H-Index: 9
view all 5 authors...
The rostral forelimb area (RFA) in the rat is considered to be a premotor cortical region based primarily on its efferent projections to the primary motor cortex. The purpose of the present study was to identify corticocortical connections of RFA, and to describe the relative strength of connections with other cortical areas. This will allow us to better understand the broader cortical network in which RFA participates, and thus, determine its function in motor behavior. In the present study, th...
Source
#1Alberto Averna (IIT: Istituto Italiano di Tecnologia)H-Index: 2
Last. David J. Guggenmos (KU: University of Kansas)H-Index: 9
view all 8 authors...
Intracortical microstimulation can be used successfully to modulate neuronal activity. Activity-dependent stimulation (ADS), in which action potentials recorded extracellularly from a single neuron are used to trigger stimulation at another cortical location (closed-loop), is an effective treatment for behavioral recovery after brain lesion, but the related neurophysiological changes are still not clear. Here, we investigated the ability of ADS and random stimulation (RS) to alter firing pattern...
Source
#1Jakob M. Townsend (OU: University of Oklahoma)H-Index: 5
#2Goksel Sali (University of Oklahoma Health Sciences Center)H-Index: 5
Last. S DetamoreMichael (OU: University of Oklahoma)H-Index: 40
view all 10 authors...
Abstract Bone regeneration of large cranial defects, potentially including traumatic brain injury (TBI) treatment, presents a major problem with non-crosslinking, clinically available products due to material migration outside the defect. Commercial products such as bone cements are permanent and thus not conducive to bone regeneration, and typical commercial bioactive materials for bone regeneration do not crosslink. Our previous work demonstrated that non-crosslinking materials may be prone to...
Source
#1Aiwane Iboaya (KU: University of Kansas)H-Index: 1
#2Janna L. Harris (KU: University of Kansas)H-Index: 9
Last. Randolph J. Nudo (KU: University of Kansas)H-Index: 48
view all 4 authors...
Traumatic brain injury (TBI) is a major cause of morbidity and mortality in the United States, with advanced age being one of the major predictors of poor prognosis. To replicate the mechanisms and...
1 CitationsSource
#1David T. Bundy (KU: University of Kansas)H-Index: 12
#2David J. Guggenmos (KU: University of Kansas)H-Index: 9
Last. Randolph J. Nudo (KU: University of Kansas)H-Index: 48
view all 4 authors...
While substantial task-related neural activity has been observed during motor tasks in rodent primary motor cortex and premotor cortex, the long-term stability of these responses in healthy rats is uncertain, limiting the interpretability of longitudinal changes in the specific patterns of neural activity associated with learning or motor recovery following injury. This study examined the stability of task-related neural activity associated with execution of two distinct reaching tasks in health...
Source
12345678910