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Jan Borén
Sahlgrenska University Hospital
385Publications
64H-index
15.8kCitations
Publications 385
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#1Ismena Mardani (Sahlgrenska University Hospital)H-Index: 1
#2Knut Tomas Dalen (University of Oslo)H-Index: 20
Last.Malin Levin (Sahlgrenska University Hospital)H-Index: 16
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Myocardial dysfunction is commonly associated with accumulation of cardiac lipid droplets (LDs). Perilipin 2 (Plin2) is a LD protein that is involved in LD formation, stability and trafficking events within the cell. Even though Plin2 is highly expressed in the heart, little is known about its role in myocardial lipid storage. A recent report shows that cardiac overexpression of Plin2 result in massive myocardial steatosis suggesting that Plin2 stabilizes LDs. In this study, we hypothesized that...
#1Alba Carreras (Sahlgrenska University Hospital)H-Index: 2
#2Alba Carreras (Sahlgrenska University Hospital)H-Index: 1
Last.Marcello MarescaH-Index: 5
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Background Plasma concentration of low-density lipoprotein (LDL) cholesterol is a well-established risk factor for cardiovascular disease. Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9), which regulates cholesterol homeostasis, has recently emerged as an approach to reduce cholesterol levels. The development of humanized animal models is an important step to validate and study human drug targets, and use of genome and base editing has been proposed as a mean to target diseas...
Abstract Aims The microsomal triglyceride transport protein (MTTP) is critical for assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins and is most abundant in the liver and intestine. Surprisingly, MTTP is also expressed in the heart. Here we tested the functional relevance of cardiac MTTP expression. Materials and methods We combined clinical studies, advanced expression analysis of human heart biopsies and analyses in genetically modified mice lacking cardiac expression o...
#2Jens B. NielsenH-Index: 84
Last.Adil MardinogluH-Index: 27
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Abstract The advancement in high-throughput sequencing technologies and systems biology approaches have revolutionized our understanding of biological systems and opened a new path to investigate unacknowledged biological phenomena. In parallel, the field of human microbiome research has greatly evolved and the relative contribution of the gut microbiome to health and disease have been systematically explored. This review provides an overview of the network-based and translational systems biolog...
Abstract Drug repositioning is a powerful method that can assists the conventional drug discovery process by using existing drugs for treatment of a disease rather than its original indication. The first examples of repurposed drugs were discovered serendipitously, however data accumulated by high-throughput screenings and advancements in computational biology methods have paved the way for rational drug repositioning methods. As chemotherapeutic agents have notorious side effects that significa...
#1Emmelie CansbyH-Index: 8
Last.Margit MahlapuuH-Index: 20
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Ectopic lipid storage in the liver is considered the main risk factor for nonalcoholic steatohepatitis (NASH). Understanding the molecular networks controlling hepatocellular lipid deposition is therefore essential for developing new strategies to effectively prevent and treat this complex disease. Here, we describe a new regulator of lipid partitioning in human hepatocytes: mammalian sterile 20–like (MST) 3. We found that MST3 protein coats lipid droplets in mouse and human liver cells. Knockdo...
#1Robert A. Hegele (UWO: University of Western Ontario)H-Index: 82
#2Jan Borén (Sahlgrenska University Hospital)H-Index: 64
Last.Alberico L. Catapano (University of Milan)H-Index: 61
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Summary Genome sequencing and gene-based therapies appear poised to advance the management of rare lipoprotein disorders and associated dyslipidaemias. However, in practice, underdiagnosis and undertreatment of these disorders are common, in large part due to interindividual variability in the genetic causes and phenotypic presentation of these conditions. To address these challenges, the European Atherosclerosis Society formed a task force to provide practical clinical guidance focusing on pati...
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