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Carol J. Bult
European Bioinformatics Institute
190Publications
53H-index
30.6kCitations
Publications 190
Newest
Published on Apr 10, 2019in F1000Research
Cynthia L. Smith20
Estimated H-index: 20
,
Carol J. Bult53
Estimated H-index: 53
+ 1 AuthorsMouse Genome Informatics
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Published on Apr 1, 2019
Wen Cai Zhang7
Estimated H-index: 7
(Beth Israel Deaconess Medical Center),
Julie Wells16
Estimated H-index: 16
+ 9 AuthorsDaniel B. Costa37
Estimated H-index: 37
(Beth Israel Deaconess Medical Center)
Drug tolerance is an acute defence response preceding a fully drug-resistant state and tumour relapse; however, there are few therapeutic agents targeting drug tolerance in the clinic. Here we show that miR-147b initiates a reversible state of tolerance to the epidermal growth factor receptor (EGFR) inhibitor osimertinib in non-small-cell lung cancer. With miRNA-seq analysis, we find that miR-147b is the most upregulated microRNA in osimertinib-tolerant and EGFR-mutated lung cancer cells. Whole-...
1 Citations Source Cite
Published on Mar 28, 2019in PeerJ 2.12
Joan Malcolm2
Estimated H-index: 2
(University of Maine),
Tim Stearns55
Estimated H-index: 55
+ 2 AuthorsCarol J. Bult53
Estimated H-index: 53
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Published on Mar 1, 2019in Pain 5.56
Jill M. Recla4
Estimated H-index: 4
,
Jason A. Bubier12
Estimated H-index: 12
+ 11 AuthorsRichard S. Maser1
Estimated H-index: 1
Identification of genetic variants that influence susceptibility to chronic pain is key to identifying molecular mechanisms and targets for effective and safe therapeutic alternatives to opioids. To identify genes and variants associated with chronic pain, we measured late phase response to formalin injection in 275 male and female Diversity Outbred (DO) mice genotyped for over 70 thousand SNPs. One quantitative trait locus (QTL) reached genome-wide significance on chromosome 1 with a support in...
1 Citations Source Cite
Published on Jan 8, 2019in Nucleic Acids Research 11.56
Carol J. Bult53
Estimated H-index: 53
,
Judith A. Blake52
Estimated H-index: 52
+ 32 AuthorsSusan M. Bello7
Estimated H-index: 7
3 Citations Source Cite
Published on Jan 8, 2019in Nucleic Acids Research 11.56
Blake A. Sweeney6
Estimated H-index: 6
,
Anton I. Petrov9
Estimated H-index: 9
+ 58 AuthorsJamie J. Cannone25
Estimated H-index: 25
4 Citations Source Cite
Published on Dec 1, 2018in Scientific Reports 4.12
Hyun Soo Kim33
Estimated H-index: 33
,
Pooja Kumar1
Estimated H-index: 1
+ 16 AuthorsHenry C. Chen
The processes by which tumors evolve are essential to the efficacy of treatment, but quantitative understanding of intratumoral dynamics has been limited. Although intratumoral heterogeneity is common, quantification of evolution is difficult from clinical samples because treatment replicates cannot be performed and because matched serial samples are infrequently available. To circumvent these problems we derived and assayed large sets of human triple-negative breast cancer xenografts and cell c...
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Published on Oct 1, 2018in Lab Animal 0.83
Douglas G. Howe13
Estimated H-index: 13
(University of Oregon),
Judith A. Blake52
Estimated H-index: 52
+ 11 AuthorsStanley J. F. Laulederkind14
Estimated H-index: 14
(Medical College of Wisconsin)
Model organism databases (MODs) have been collecting and integrating biomedical research data for 30 years and were designed to meet specific needs of each model organism research community. The contributions of model organism research to understanding biological systems would be hard to overstate. Modern molecular biology methods and cost reductions in nucleotide sequencing have opened avenues for direct application of model organism research to elucidating mechanisms of human diseases. Thus, t...
5 Citations Source Cite
Published on Sep 12, 2018in bioRxiv
Xing Yi Woo11
Estimated H-index: 11
,
Anuj Srivastava10
Estimated H-index: 10
+ 13 AuthorsRangjiao Liu2
Estimated H-index: 2
Bioinformatics workflows for analyzing genomic data obtained from xenografted tumor (e.g., human tumors engrafted in a mouse host) must address several challenges, including separating mouse and human sequence reads and accurate identification of somatic mutations and copy number aberrations when paired normal DNA from the patient is not available. We report here data analysis workflows that address these challenges and result in reliable identification of somatic mutations, copy number alterati...
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