Mark I. McCarthy
University of Oxford
Genome-wide association studyEndocrinologyGeneticsMedicineBiology
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Publications 1228
#1Agata Juszczak (University of Oxford)H-Index: 4
Last. Katharine R. Owen (University of Oxford)H-Index: 33
view all 8 authors...
#1Yan Zheng (Fudan University)
#2Tao Huang (PKU: Peking University)H-Index: 29
Last. Rob M. van Dam (NUS: National University of Singapore)H-Index: 87
view all 118 authors...
Epidemiology studies suggested that low birthweight was associated with a higher risk of hypertension in later life. However, little is known about the causality of such associations. In our study, we evaluated the causal association of low birthweight with adulthood hypertension following a standard analytic protocol using the study-level data of 183,433 participants from 60 studies (CHARGE-BIG consortium), as well as that with blood pressure using publicly available summary-level genome-wide a...
#1Anil K. Giri (Institute of Genomics and Integrative Biology)H-Index: 6
#2Indico (Institute of Genomics and Integrative Biology)H-Index: 1
Last. Donaka Rajashekar (Institute of Genomics and Integrative Biology)H-Index: 1
view all 16 authors...
Obesity, a risk factor for multiple diseases (e.g. diabetes, hypertension, cancers) originates through complex interactions between genes and prevailing environment (food habit and lifestyle) that varies across populations. Indians exhibit a unique obesity phenotype with high abdominal adiposity for a given body weight compared to matched white populations suggesting presence of population-specific genetic and environmental factors influencing obesity. However, Indian population-specific genetic...
#1M. Geoffrey Hayes (NU: Northwestern University)H-Index: 30
#2Margrit Urbanek (NU: Northwestern University)H-Index: 32
Last. Stephen Franks (Imperial College London)H-Index: 77
view all 23 authors...
#1Samuela PollackH-Index: 11
Last. Ayellet V. SegrèH-Index: 26
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#1Katherine Minjee Chung (MIT: Massachusetts Institute of Technology)H-Index: 2
#2Jaffarguriqbal Singh (Yale University)
Last. Xiaojian Zhao (Yale University)H-Index: 8
view all 29 authors...
Summary Obesity is a major modifiable risk factor for pancreatic ductal adenocarcinoma (PDAC), yet how and when obesity contributes to PDAC progression is not well understood. Leveraging an autochthonous mouse model, we demonstrate a causal and reversible role for obesity in early PDAC progression, showing that obesity markedly enhances tumorigenesis, while genetic or dietary induction of weight loss intercepts cancer development. Molecular analyses of human and murine samples define microenviro...
1 CitationsSource
#1Robin N. Beaumont (University of Exeter)H-Index: 16
#2Sarah J. Kotecha (Cardiff University)H-Index: 11
Last. Rachel M. Freathy (University of Exeter)H-Index: 36
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Babies born clinically Small- or Large-for-Gestational-Age (SGA or LGA; sex- and gestational age-adjusted birth weight (BW) 90th percentile, respectively), are at higher risks of complications. SGA and LGA include babies who have experienced growth-restriction or overgrowth, respectively, and babies who are naturally small or large. However, the relative proportions within each group are unclear. We aimed to assess the extent to which the genetics of normal variation in birth weight influence th...
#1Naeimeh Atabaki-Pasdar (Lund University)H-Index: 3
#2Mattias Ohlsson (Lund University)H-Index: 27
Last. Azra Kurbasic (Lund University)H-Index: 6
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Background: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in type 2 diabetes (T2D) and beyond. Early diagnosis of NAFLD is important, as this can help prevent irreversible damage to the liver and ultimately hepatocellular carcinomas. Methods and Findings: Utilizing the baseline data from the IMI DIRECT participants (n=1514) we sought to expand etiological understanding and develop a diagnostic tool for NAFLD using machine learning. Multi-om...
#1Katherine S. Ruth (University of Exeter)H-Index: 18
#2Felix R Day (Medical Research Council)H-Index: 1
Last. Alexander S. Busch (Medical Research Council)H-Index: 6
view all 22 authors...
Testosterone supplementation is commonly used for its effects on sexual function, bone health and body composition, yet its effects on disease outcomes are unknown. To better understand this, we identified genetic determinants of testosterone levels and related sex hormone traits in 425,097 UK Biobank study participants. Using 2,571 genome-wide significant associations, we demonstrate that the genetic determinants of testosterone levels are substantially different between sexes and that genetica...
4 CitationsSource
#1Paul Petrus (KI: Karolinska Institutet)H-Index: 5
#2Simon Lecoutre (KI: Karolinska Institutet)H-Index: 2
Last. Mikael Rydén (KI: Karolinska Institutet)H-Index: 43
view all 20 authors...
Summary While obesity and associated metabolic complications are linked to inflammation of white adipose tissue (WAT), the causal factors remain unclear. We hypothesized that the local metabolic environment could be an important determinant. To this end, we compared metabolites released from WAT of 81 obese and non-obese women. This identified glutamine to be downregulated in obesity and inversely associated with a pernicious WAT phenotype. Glutamine administration in vitro and in vivo attenuate...
3 CitationsSource