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John R Benson
Cambridge University Hospitals NHS Foundation Trust
157Publications
19H-index
1,544Citations
Publications 157
Newest
#1Maurizio Bruno Nava (University of Milan)H-Index: 11
#2John R Benson (ARU: Anglia Ruskin University)H-Index: 19
Last.Jacek Jassem (Gdańsk Medical University)H-Index: 58
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#1John R Benson (University of Cambridge)H-Index: 19
#2Ismail Jatoi (University of Texas Health Science Center at San Antonio)H-Index: 26
Last.Masakazu Toi (Kyoto University)H-Index: 63
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#1Ismail Jatoi (University of Texas at Austin)H-Index: 26
#2John R Benson (Cambridge University Hospitals NHS Foundation Trust)H-Index: 19
Last.Maskazu Toi (Kyoto University)
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#1Satish KumarH-Index: 6
#2John R BensonH-Index: 19
Last.Elena ProvenzanoH-Index: 34
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Background: Published preclinical findings provided new insights into the functional 9cross-talk9 between the oestrogen receptor (ER) and the progesterone receptor (PR) in breast cancer (BC) (Mohammed et al., Nature, 2015). Addition of a PR agonist to anti-oestrogens directly modifies ERa chromatin binding and the transcriptional response in breast cancer cells, and is anti-proliferative in vitro and in vivo . Megestrol Acetate (MA), an off-patent semi-synthetic derivative of progesterone, has b...
#1John R BensonH-Index: 19
Last.Elena ProvenzanoH-Index: 34
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#1Ismail Jatoi (University of Texas Health Science Center at San Antonio)H-Index: 26
#2John R Benson (ARU: Anglia Ruskin University)H-Index: 19
Last.Ian Kunkler (Western General Hospital)H-Index: 30
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Radiotherapy is an integral component of loco-regional therapy for breast cancer. Randomized controlled trials indicate that increasing the extent of extirpative surgery primarily reduces the risk of local recurrences, while the addition of radiotherapy to surgery can also reduce the risk of distant recurrences, thereby lowering breast cancer-specific mortality. This may suggest an “abscopal” effect beyond the immediate zone of loco-regional irradiation that favorably perturbs the natural histor...
#1Ramsey I. Cutress (University of Southampton)H-Index: 20
#2Stuart McIntosh ('QUB': Queen's University Belfast)H-Index: 13
Last.Js Vaidya (UCL: University College London)H-Index: 26
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The Breast Cancer Campaign Gap analysis (2013) established breast cancer research priorities without specific focus on surgical research nor the role of surgeons. The majority of breast cancer patients encounter a surgeon at diagnosis or during treatment, thus surgical involvement in design and delivery of high-quality research to improve patient care is critical. This review aims to identify opportunities and priorities for breast surgical research to complement the previous gap analysis.
#1John R Benson (Cambridge University Hospitals NHS Foundation Trust)H-Index: 19
#2Ismail Jatoi (University of Texas Health Science Center at San Antonio)H-Index: 26
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