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Luca Bernasconi
35Publications
6H-index
119Citations
Publications 34
Newest
#1Tristan StrujaH-Index: 4
#2Rebecca JutziH-Index: 1
Last.Philipp Schuetz (University of Basel)H-Index: 49
view all 13 authors...
Early diagnosis and relapse prediction in Graves’ disease influences treatment. We assessed the abilities of four TSH-receptor antibody tests [TRAb] and one cyclic adenosine monophosphate bioassay to predict relapse of Graves’ disease. Observational study investigating patients presenting with Graves’ disease at a Swiss hospital endocrine referral center or an endocrine outpatient clinic. Main outcomes were diagnosis and relapse of Graves’ disease after stop of anti-thyroid drugs. We used Cox re...
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1 CitationsSource
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#1Hansotto ReiberH-Index: 27
#2David Zeman (University of Ostrava)H-Index: 5
Last.Luca BernasconiH-Index: 6
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Abstract Background Free light chains, type kappa (FLC-K), in cerebrospinal fluid (CSF) were compared to oligoclonal IgG in many studies for sensitive detection of immune reactions in brain. The missing consensus about CSF data interpretation prevents reliable conclusions. This can be overcome by a theory-based hyperbolic reference range in CSF/serum quotient diagrams. Methods Mean Quotients for FLC-K, QKappa, and albumin, QAlb, of grouped, biochemically defined controls (N = 433) are fitted wit...
1 CitationsSource
#1Fahim Ebrahimi (University of Basel)H-Index: 4
#2Sandrine A Urwyler (University of Basel)H-Index: 6
Last.Mirjam Christ-Crain (University of Basel)H-Index: 53
view all 8 authors...
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#1Tristan StrujaH-Index: 4
#2Andreas EckartH-Index: 1
Last.Philipp Schuetz (University of Basel)H-Index: 49
view all 9 authors...
Early diagnosis of thyroid disorders is key to further treatment. We assessed the ability of a high-throughput proton NMR metabolomic profile to distinguish disease type amongst of Graves’ disease (n=87), Hashimoto’s thyroiditis (n=17), toxic goiter (n=11), and autoimmune thyroiditis [i. e., subacute thyroiditis (n=4), postpartum thyroiditis (n=1)]. This observational study was conducted investigating patients presenting with a thyroid disorder at a Swiss hospital endocrine referral center and a...
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#1Clara O Sailer (University of Basel)H-Index: 3
#2Bettina Winzeler (University of Basel)H-Index: 7
Last.Mirjam Christ-Crain (University of Basel)H-Index: 53
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#1Thomas BaumgartnerH-Index: 21
#2Giedre ZurauskaiteH-Index: 1
Last.Philipp SchuetzH-Index: 49
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Oxidative stress is a modifiable risk-factor in infection causing damage to human cells. As an adaptive response, cells catabolize Tyrosine to 3-Nitrotyrosine (Tyr-NO2) by nitrosylation. We investigated whether a more efficient reduction in oxidative stress, mirrored by a lowering of Tyrosine, and an increase in Tyr-NO2 and the Tyrosine/Tyr-NO2 ratio was associated with better clinical outcomes in patients with community-acquired pneumonia (CAP). We measured Tyrosine and Tyr-NO2 in CAP patients ...
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#1Seline ZurfluhH-Index: 2
#2Manuela NicklerH-Index: 5
Last.Philipp SchuetzH-Index: 49
view all 14 authors...
Adrenal hormone metabolite levels are altered in acute illnesses such as community-acquired pneumonia (CAP). Our aim was to investigate associations of sex and mineralocorticoid hormone metabolites with short- and long-term mortality and severity of CAP in male and female patients. We prospectively followed 285 patients (60.4% male, mean age 71 years) with CAP from a previous multicenter trial. At baseline, levels of different metabolites of sex hormones and mineralocorticoids were measured by l...
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