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Fabrice Navarro
Commissariat à l'énergie atomique et aux énergies alternatives
MicroscopyNanoparticleFluorescence-lifetime imaging microscopyCell cultureFluorescence
56Publications
12H-index
483Citations
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Publications 58
Newest
#1Ozgul Tezgel (CNRS: Centre national de la recherche scientifique)H-Index: 2
#2Nicholas DiStasioH-Index: 1
Last. Isabelle TexierH-Index: 19
view all 8 authors...
Abstract Achieving prolonged and localized delivery of small interfering RNA (siRNA) at a specific site is highly desirable, since siRNA therapy has become a promising strategy for many medical applications. Many different synthetic or natural biomaterials have been studied for local sustained drug delivery. Of those, collagen has received increased attention, especially for wound applications, due to its biocompatibility, safety, and hemostatic properties. Therefore, we here investigated freeze...
1 CitationsSource
#1Laurent DevelH-Index: 15
#2Gunter AlmerH-Index: 17
Last. Isabelle TexierH-Index: 19
view all 10 authors...
Atherosclerosis is a major cardiovascular disease worldwide, that could benefit from innovative nanomedicine imaging tools and treatments. In this perspective, we here studied, by fluorescence imaging in ApoE-/- mice, the biodistribution of non-functionalized and RXP470.1-targeted nanostructured lipid carriers (NLC) loaded with DiD dye. RXP470.1 specifically binds to MMP12, a metalloprotease that is over-expressed by macrophages residing in atherosclerotic plaques. Physico-chemical characterizat...
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#1Lionel HervéH-Index: 2
#2Cédric AllierH-Index: 2
Last. Sophie MoralesH-Index: 2
view all 6 authors...
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#1Valentina Laghezza Masci (Tuscia University)H-Index: 4
#2Annarita Taddei (Tuscia University)H-Index: 6
Last. Isabelle TexierH-Index: 19
view all 9 authors...
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#1Lionel HervéH-Index: 13
#2Olivier CioniH-Index: 4
Last. Cédric AllierH-Index: 13
view all 8 authors...
Lens-free microscopy multispectral acquisitions are processed with an inverse problem approach: a multispectral total variation criterion is defined and minimized with the conjugate gradients method. Reconstruction results show that the method is efficient to recover the phase image of densely packed cells.
5 CitationsSource
#1Emilie Bayon (French Institute of Health and Medical Research)H-Index: 2
#2Jessica MorlierasH-Index: 1
Last. Fabrice NavarroH-Index: 12
view all 9 authors...
HIV is one of the deadliest pandemics of modern times, having already caused 35 million deaths around the world. Despite the huge efforts spent to develop treatments, the virus cannot yet be eradicated and continues to infect new people. Spread of the virus remains uncontrolled, thus exposing the worldwide population to HIV danger, due to the lack of efficient vaccines. The latest clinical trials describe the challenges associated with developing an effective prophylactic HIV vaccine. These immu...
3 CitationsSource
#1Emilie BayonH-Index: 2
#2Nathalie BosquetH-Index: 3
Last. Fabrice NavarroH-Index: 12
view all 8 authors...
#1Cédric AllierH-Index: 13
#2R. VincentH-Index: 1
Last. Sophie MoralesH-Index: 2
view all 13 authors...
We present our implementation of lens-free video microscopy setup for the monitoring of adherent cell cultures. We use a multi-wavelength LED illumination together with a dedicated holographic reconstruction algorithm that allows for an efficient removal of twin images from the reconstructed phase image for densities up to those of confluent cell cultures (>500 cells/mm 2 ). We thereby demonstrate that lens-free video microscopy, with a large field of view (~30 mm 2 ) can enable us to capture th...
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#1Cédric AllierH-Index: 13
#2Romaric VincentH-Index: 1
Last. Sophie MoralesH-Index: 2
view all 13 authors...
Here, we demonstrate that lens-free video microscopy enables us to simultaneously capture the kinetics of thousands of cells directly inside the incubator and that it is possible to monitor and quantify single cells along several cell cycles. We describe the full protocol used to monitor and quantify a HeLa cell culture for 2.7 days. First, cell culture acquisition is performed with a lens-free video microscope, and then the data is analyzed following a four-step process: multi-wavelength hologr...
1 CitationsSource
#1Lionel HervéH-Index: 2
#2Cédric AllierH-Index: 2
Last. Sophie MoralesH-Index: 2
view all 8 authors...
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