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Michael M. Swarbrick
Garvan Institute of Medical Research
20Publications
8H-index
668Citations
Publications 20
Newest
Published on Oct 1, 2017in Diabetologia7.11
Rebecca A. Stokes10
Estimated H-index: 10
(USYD: University of Sydney),
Kim Cheng8
Estimated H-index: 8
(Garvan Institute of Medical Research)
+ 7 AuthorsJenny E. Gunton29
Estimated H-index: 29
Aims/hypothesis Beta cell replacement is a potential cure for type 1 diabetes. In humans, islet transplants are currently infused into the liver via the portal vein, although this site has disadvantages. Here, we investigated alternative transplantation sites for human and murine islets in recipient mice, comparing the portal vein with quadriceps muscle and kidney, liver and spleen capsules.
Published on Sep 17, 2015in Medical research archives
Tara S. Rogers4
Estimated H-index: 4
,
Peter J. Havel67
Estimated H-index: 67
+ 5 AuthorsMarta D. Van Loan29
Estimated H-index: 29
Bariatric surgery is associated with increased bone turnover. The mechanisms involved are unclear but may involve nutrition, mechanical unloading, altered secretion of gastrointestinal and adipose hormones and changes in inflammatory status leading to weight loss induced bone loss. We assessed markers of bone turnover in obese adults (F=19, M=1; BMI 46.5 + 7.9 kg/m2) following Roux-en-Y gastric bypass surgery (RYGB), and investigated their relationship to endocrine and inflammatory markers follo...
Published on Jul 1, 2015in Diabetologia7.11
Samantha L. Hocking7
Estimated H-index: 7
(Garvan Institute of Medical Research),
Rebecca L. Stewart2
Estimated H-index: 2
(Garvan Institute of Medical Research)
+ 14 AuthorsJenny E. Gunton29
Estimated H-index: 29
(USYD: University of Sydney)
Aims/hypothesis Adipose tissue (AT) distribution is a major determinant of mortality and morbidity in obesity. In mice, intra-abdominal transplantation of subcutaneous AT (SAT) protects against glucose intolerance and insulin resistance (IR), but the underlying mechanisms are not well understood. Methods We investigated changes in adipokines, tissuespecific glucose uptake, gene expression and systemic inflammation in male C57BL6/J mice implanted intra-abdominally with either inguinal SATor epidi...
Published on Jun 1, 2015in Cell Metabolism22.41
Paul Lee13
Estimated H-index: 13
(Garvan Institute of Medical Research),
Michael M. Swarbrick8
Estimated H-index: 8
(Millennium Institute),
Jerry R. Greenfield35
Estimated H-index: 35
(Garvan Institute of Medical Research)
FGF21 mimetics are a promising therapeutic tool, believed to exert their anti-obesity effect partly through browning of white fat. Veniant et al. (2015) and Samms et al. (2015) present evidence arguing against fat browning as the primary mechanism causal to weight loss following FGF21-based treatment in mice.
Published on Dec 1, 2014in Obesity Research & Clinical Practice2.06
Frank L.S. Kyang , Rebecca L. Stewart2
Estimated H-index: 2
(Garvan Institute of Medical Research)
+ 3 AuthorsReginald V. Lord37
Estimated H-index: 37
(University of Notre Dame Australia)
Published on Dec 1, 2014in Obesity Research & Clinical Practice2.06
Samantha L. Hocking7
Estimated H-index: 7
(Garvan Institute of Medical Research),
Rebecca L. Stewart2
Estimated H-index: 2
(Garvan Institute of Medical Research)
+ 9 AuthorsBenjamin R. Herbert6
Estimated H-index: 6
(Macquarie University)
Published on Nov 1, 2014in Diabetes7.20
Michael M. Swarbrick8
Estimated H-index: 8
(Garvan Institute of Medical Research)
In the 60 years since Vague (1) described that an “android” pattern of adipose tissue (AT) distribution was associated with diabetes, atherosclerosis, gout, and kidney stones, many of the physiological mechanisms underlying this relationship have been illuminated. To date, most of the effort has been directed at understanding how accumulation of intra-abdominal fat, also known as visceral AT (VAT), promotes insulin resistance (IR). IR is the common defect underlying glucose intolerance, central ...
Published on Sep 1, 2014in Cell Metabolism22.41
Michele Petruzzelli1
Estimated H-index: 1
(BBVA Compass),
Martina Schweiger25
Estimated H-index: 25
(University of Graz)
+ 9 AuthorsGraham Robertson1
Estimated H-index: 1
(Garvan Institute of Medical Research)
Summary Cancer-associated cachexia (CAC) is a wasting syndrome characterized by systemic inflammation, body weight loss, atrophy of white adipose tissue (WAT) and skeletal muscle. Limited therapeutic options are available and the underlying mechanisms are poorly defined. Here we show that a phenotypic switch from WAT to brown fat, a phenomenon termed WAT browning, takes place in the initial stages of CAC, before skeletal muscle atrophy. WAT browning is associated with increased expression of unc...
Published on Jun 1, 2013in Endocrine Reviews15.17
Paul Lee11
Estimated H-index: 11
(Princess Alexandra Hospital),
Michael M. Swarbrick8
Estimated H-index: 8
(Garvan Institute of Medical Research),
Ken K. Y. Ho54
Estimated H-index: 54
(Princess Alexandra Hospital)
Brown adipose tissue (BAT) plays a key role in energy homeostasis and thermogenesis in animals, conferring protection against diet-induced obesity and hypothermia through the action of uncoupling protein 1 (UCP1). Recent metabolic imaging studies using positron emission tomography computerized tomography (PET-CT) scanning have serendipitously revealed significant depots of BAT in the cervical-supraclavicular regions, demonstrating persistence of BAT beyond infancy. Subsequent cold-stimulated PET...
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