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Michael M. Swarbrick
Garvan Institute of Medical Research
19Publications
8H-index
724Citations
Publications 20
Newest
#2Rebecca A. StokesH-Index: 11
Last.Jenny E. GuntonH-Index: 30
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#1Rebecca A. Stokes (USYD: University of Sydney)H-Index: 11
#2Kim Cheng (Garvan Institute of Medical Research)H-Index: 9
Last.Jenny E. GuntonH-Index: 30
view all 10 authors...
Aims/hypothesis Beta cell replacement is a potential cure for type 1 diabetes. In humans, islet transplants are currently infused into the liver via the portal vein, although this site has disadvantages. Here, we investigated alternative transplantation sites for human and murine islets in recipient mice, comparing the portal vein with quadriceps muscle and kidney, liver and spleen capsules.
13 CitationsSource
#1Tara S. RogersH-Index: 5
#2Peter J. HavelH-Index: 71
Last.Marta D. Van LoanH-Index: 31
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Bariatric surgery is associated with increased bone turnover. The mechanisms involved are unclear but may involve nutrition, mechanical unloading, altered secretion of gastrointestinal and adipose hormones and changes in inflammatory status leading to weight loss induced bone loss. We assessed markers of bone turnover in obese adults (F=19, M=1; BMI 46.5 + 7.9 kg/m2) following Roux-en-Y gastric bypass surgery (RYGB), and investigated their relationship to endocrine and inflammatory markers follo...
#1Samantha L. Hocking (Garvan Institute of Medical Research)H-Index: 7
#2Rebecca L. Stewart (Garvan Institute of Medical Research)H-Index: 2
Last.Michael M. Swarbrick (UNSW: University of New South Wales)H-Index: 8
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Aims/hypothesis Adipose tissue (AT) distribution is a major determinant of mortality and morbidity in obesity. In mice, intra-abdominal transplantation of subcutaneous AT (SAT) protects against glucose intolerance and insulin resistance (IR), but the underlying mechanisms are not well understood. Methods We investigated changes in adipokines, tissuespecific glucose uptake, gene expression and systemic inflammation in male C57BL6/J mice implanted intra-abdominally with either inguinal SATor epidi...
24 CitationsSource
#1Paul Lee (Garvan Institute of Medical Research)H-Index: 14
#2Michael M. Swarbrick (Millennium Institute)H-Index: 8
Last.Jerry R. Greenfield (Garvan Institute of Medical Research)H-Index: 36
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FGF21 mimetics are a promising therapeutic tool, believed to exert their anti-obesity effect partly through browning of white fat. Veniant et al. (2015) and Samms et al. (2015) present evidence arguing against fat browning as the primary mechanism causal to weight loss following FGF21-based treatment in mice.
4 CitationsSource
#2Rebecca L. Stewart (Garvan Institute of Medical Research)H-Index: 2
Last.Reginald V. Lord (University of Notre Dame Australia)H-Index: 38
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#1Samantha L. Hocking (Garvan Institute of Medical Research)H-Index: 7
#2Rebecca L. Stewart (Garvan Institute of Medical Research)H-Index: 2
Last.Michael M. Swarbrick (UNSW: University of New South Wales)H-Index: 8
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#1Michael M. Swarbrick (Garvan Institute of Medical Research)H-Index: 8
In the 60 years since Vague (1) described that an “android” pattern of adipose tissue (AT) distribution was associated with diabetes, atherosclerosis, gout, and kidney stones, many of the physiological mechanisms underlying this relationship have been illuminated. To date, most of the effort has been directed at understanding how accumulation of intra-abdominal fat, also known as visceral AT (VAT), promotes insulin resistance (IR). IR is the common defect underlying glucose intolerance, central ...
3 CitationsSource
#1Michele Petruzzelli (BBVA Compass)H-Index: 1
#2Martina Schweiger (University of Graz)H-Index: 26
Last.Erwin F. Wagner (BBVA Compass)H-Index: 115
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Summary Cancer-associated cachexia (CAC) is a wasting syndrome characterized by systemic inflammation, body weight loss, atrophy of white adipose tissue (WAT) and skeletal muscle. Limited therapeutic options are available and the underlying mechanisms are poorly defined. Here we show that a phenotypic switch from WAT to brown fat, a phenomenon termed WAT browning, takes place in the initial stages of CAC, before skeletal muscle atrophy. WAT browning is associated with increased expression of unc...
227 CitationsSource
#1Michael M. Swarbrick (Garvan Institute of Medical Research)H-Index: 8
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