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Adolfo López de Munain
University of the Basque Country
Publications 147
Published on Apr 26, 2019in Brain 10.85
Tim W. Rattay8
Estimated H-index: 8
(University of Tübingen),
Tobias Lindig5
Estimated H-index: 5
+ 27 AuthorsJennifer Reichbauer2
Estimated H-index: 2
(University of Tübingen)
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Alicia Alonso-Jimenez2
Estimated H-index: 2
(Autonomous University of Barcelona),
Rosemarie H M J M Kroon (Radboud University Nijmegen)+ 47 AuthorsCarmen Paradas13
Estimated H-index: 13
(Spanish National Research Council)
Background and objective Oculopharyngeal muscular dystrophy (OPMD) is a genetic disorder caused by an abnormal expansion of GCN triplets within the PABPN1 gene. Previous descriptions have focused on lower limb muscles in small cohorts of patients with OPMD, but larger imaging studies have not been performed. Previous imaging studies have been too small to be able to correlate imaging findings to genetic and clinical data. Methods We present cross-sectional, T1-weighted muscle MRI and CT-scan dat...
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Published on Apr 1, 2019in Molecular Neurobiology 5.08
Sokhna M.S. Yakhine-Diop5
Estimated H-index: 5
(University of Extremadura),
Mireia Niso-Santano23
Estimated H-index: 23
(University of Extremadura)
+ 11 AuthorsJ. Mark Cooper26
Estimated H-index: 26
(University College London)
Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disorder. While most PD cases are idiopathic, the known genetic causes of PD are useful to understand common disease mechanisms. Recent data suggests that autophagy is regulated by protein acetylation mediated by histone acetyltransferase (HAT) and histone deacetylase (HDAC) activities. The changes in histone acetylation reported to be involved in PD pathogenesis have prompted this investigation of protein acetylation and HA...
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Published on Dec 1, 2018in Muscle & Nerve 2.50
David Gómez-Andrés5
Estimated H-index: 5
Jordi Díaz-Manera19
Estimated H-index: 19
(Autonomous University of Barcelona)
+ 15 AuthorsN. Muelas11
Estimated H-index: 11
1 Citations Source Cite
Published on Dec 1, 2018in Molecular Neurodegeneration 6.43
Jesús Madero-Pérez7
Estimated H-index: 7
(Spanish National Research Council),
Elena Fdez10
Estimated H-index: 10
(Spanish National Research Council)
+ 19 AuthorsAngus C. Nairn106
Estimated H-index: 106
(Yale University)
Mutations in LRRK2 are a common genetic cause of Parkinson’s disease (PD). LRRK2 interacts with and phosphorylates a subset of Rab proteins including Rab8a, a protein which has been implicated in various centrosome-related events. However, the cellular consequences of such phosphorylation remain elusive. Human neuroblastoma SH-SY5Y cells stably expressing wildtype or pathogenic LRRK2 were used to test for polarity defects in the context of centrosomal positioning. Centrosomal cohesion deficits w...
10 Citations Source Cite
Published on Dec 1, 2018in Scientific Reports 4.12
Maitane Ezquerra-Inchausti2
Estimated H-index: 2
(Ministry of Economy),
Ander Anasagasti3
Estimated H-index: 3
+ 5 AuthorsJavier Ruiz-Ederra1
Estimated H-index: 1
(Ministry of Economy)
This work was supported by grants from the National Institute of Health Carlos III (Institute of Health Carlos III/ISCIII) (CP10/00572, PI13/02621 and RD16/0008/0027 to JRE, PI17/01413 to CI, and a Research Intensification Contract to ALdM); the Basque Government's Industry Department (SAIOTEK: SAIO11-PE11BN002; and SAIO12-PC12BN001 to JRE), a grant from the Mutua Madrilena Foundation and support from the Retinitis Pigmentosa Patients of Gipuzkoa Foundation (BEGISARE). JR-E is a Miguel Servet II...
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Published on Nov 28, 2018in Frontiers in Aging Neuroscience 3.58
Gorka Fernández-Eulate , Ainhoa Alberro2
Estimated H-index: 2
+ 19 AuthorsNora Soberón3
Estimated H-index: 3
Many factors may converge in healthy ageing in the oldest old, but their association and predictive power on healthy o functionally impaired ageing has yet to be demonstrated. By detecting healthy ageing and in turn, poor ageing, we could take action to prevent chronic diseases associated with age. We conducted a pilot study comparing results of a set of markers (peripheral blood mononuclear cell telomere length or PBMC, circulating Aβ peptides, anti-Aβ antibodies, and ApoE status) previously as...
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