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Ichizo Kobayashi
University of Tokyo
GeneRestriction enzymeMolecular biologyGeneticsBiology
162Publications
39H-index
6,501Citations
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Publications 163
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#1Ichizo Kobayashi (Kyorin University)H-Index: 39
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Double-strand breakage of DNA is a process central to life and death in DNA-coded organisms. Its sensitive and quantitative detection is realized by pulsed-field gel electrophoresis of a huge (Mb) circular chromosome. A single double-strand break at one of its millions of potential sites will make it linear and release it from branches of an agarose jungle. Then the huge fragments will move according to their size. We developed this method to analyze formation of DNA double-strand breaks and the...
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#1Masaki FukuyoH-Index: 8
#2Hirokazu YanoH-Index: 16
Last. Ichizo KobayashiH-Index: 39
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#1Yingbiao Zhang (UTokyo: University of Tokyo)H-Index: 1
#2Tomoyuki Matsuzaka (Hiroshima University)H-Index: 1
Last. Ichizo KobayashiH-Index: 39
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1 CitationsSource
#1Masaki FukuyoH-Index: 8
#2Toshiaki NakanoH-Index: 18
Last. Ichizo KobayashiH-Index: 39
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#1Kenji K. KojimaH-Index: 27
#2Yoshikazu Furuta (UTokyo: University of Tokyo)H-Index: 14
Last. Ichizo Kobayashi (UTokyo: University of Tokyo)H-Index: 39
view all 10 authors...
11 CitationsSource
#1Iwona Mruk (University of Gdańsk)H-Index: 8
#2Ichizo Kobayashi (UTokyo: University of Tokyo)H-Index: 39
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#1Ikuo Uchiyama (National Institute for Basic Biology, Japan)H-Index: 32
#2Jacob Albritton (UTokyo: University of Tokyo)H-Index: 1
Last. Ichizo KobayashiH-Index: 39
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Genomes of a given bacterial species can show great variation in gene content and thus systematic analysis of the entire gene repertoire, termed the pan-genome, is important for understanding bacterial intra-species diversity, population genetics, and evolution. Here, we analyzed the pan-genome from 30 completely sequenced strains of the human gastric pathogen Helicobacter pylori belonging to various phylogeographic groups, focusing on 991 accessory (not fully conserved) orthologous groups (OGs)...
9 CitationsSource
#1Koji Yahara (Swansea University)H-Index: 11
#2Yoshikazu Furuta (UTokyo: University of Tokyo)H-Index: 14
Last. Ichizo Kobayashi (UTokyo: University of Tokyo)H-Index: 39
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Selection has been a central issue in biology in eukaryotes as well as prokaryotes. Inference of selection in recombining bacterial species, compared with clonal ones, has been a challenge. It is not known how codons under diversifying selection are distributed along the chromosome or among functional categories or how frequently such codons are subject to mutual homologous recombination. Here, we explored these questions by analysing genes present in >90% among 29 genomes of Helicobacter pylori...
7 CitationsSource
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