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Xing Zheng
University of South China
31Publications
9H-index
326Citations
Publications 31
Newest
#1Zehua Yang (University of South China)
#2Fang Xiao (University of South China)
Last.Xing Zheng (University of South China)H-Index: 9
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AbstractFlavan-3-ols are a series of natural products widely present in plants and show versatile biological activities. The structures of such compounds are characterized by owing two adjacent chi...
#1Yue Zhu (University of South China)
#2Xu Yao (University of South China)
Last.Xing Zheng (University of South China)H-Index: 9
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#1Yang Li (University of South China)H-Index: 1
#2Yan-peng Li (University of South China)H-Index: 1
Last.Yunmei Liu (University of South China)H-Index: 5
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#1Zhuo Liu (CAS: Chinese Academy of Sciences)
#2Jin Long (CAS: Chinese Academy of Sciences)
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Abstract As trifluoromethylthiolation has received increasing attention recently, many CF3S-reagents and trifluoromethylthiolation methods have been developed. Herein we describe trifluoromethylthiolation of alkyl halides by using Ph3P+CF2CO2− as a fluoride and difluorocarbene source. Difluorocarbene is a versatile intermediate, but its side reactions are usually ignored and the by-products would therefore be discarded. In this work, a side reaction of difluorocarbene, the generation of a fluori...
#1Jin Long (CAS: Chinese Academy of Sciences)
#2Jia Chen (CAS: Chinese Academy of Sciences)H-Index: 10
Last.Ji-Chang Xiao (CAS: Chinese Academy of Sciences)H-Index: 31
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Ph3P/I–-promoted dichlorination and dibromination of epoxides by using XCH2CH2X (X = Cl or Br) as the halogen source and reaction solvent is described. All reagents are widely available and easy to handle, and mild conditions and operational simplicity make this protocol attractive.
#1Xiangping Deng (University of South China)H-Index: 4
#2Zhongli Li (University of South China)H-Index: 1
Last.Guotao Tang (University of South China)H-Index: 4
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Abstract In this study, we investigated the anticancer effects of FS-7, a flavonoid salicylate derivative, in human gastric carcinoma MGC-803 cell line and studied its preliminary anticancer effects. FS-7 displayed greater in vitro cytotoxicity against MGC-803 cell line compared with 5-Fu and had a certain extent of selectivity to cancer cells. The flow cytometry analysis revealed that FS-7 induced apoptosis MGC-803 cells and mainly caused cells arrest in the G2/M phase in a concentration-depend...
#1Xiangping Deng (University of South China)H-Index: 4
#2Renbo Liu (University of South China)H-Index: 1
Last.Guotao Tang (University of South China)H-Index: 4
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According to the pharmacophore combination principle, a set of new 3′,4′,5′-trimethoxy flavonoid salicylate derivatives were designed, synthesized, and evaluated for biological activity. The cytotoxicity evaluation revealed that compound 10v exhibited higher potency than 5-Fu against HCT-116 cells. Preliminary biological activity studies showed that compound 10v could inhibit the colony formation and migration of HCT-116 cells. Besides, the Hoechst 33258 staining assay and flow cytometry reveale...
#1Zhe Wang (University of South China)H-Index: 4
#2Xiangping Deng (University of South China)H-Index: 4
Last.Guotao Tang (University of South China)H-Index: 4
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AbstractA series of chrysin benzimidazole derivatives were synthesised and evaluated for their anticancer activity in the search for potential anticancer agents. Among them, compound 18 displayed t...
#1Xiangping Deng (University of South China)H-Index: 4
#2Zihao Zhao (University of South China)H-Index: 2
Last.Guotao Tang (University of South China)H-Index: 4
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AbstractA series of chrysin salicylate derivatives as potential antitumour agents were synthesised and evaluated their antitumour activities in vitro and in vivo. Most of the compounds exhibited moderate to good activities against MCF-7 cells, HepG2 cells, MGC-803cells and MFC cells. Among them, compound 3f showed the most potent activity against MGC-803 cells and MFC cells with IC50 values of 23.83 ± 3.68 and 27.34 ± 5.21 μM, respectively. The flow cytometry assay reconfirmed that compound 3f p...
#1Qiu-xia Huang (University of South China)H-Index: 2
#2Hong-fei Chen (University of South China)H-Index: 2
Last.Xing Zheng (University of South China)H-Index: 9
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Firstly discovered in 1980s, human immunodeficiency virus (HIV) continues to affect more and more people. However, there is no effective drug available for the therapy of HIV infection. Betulinic acid existing in various medicinal herbs and fruits exhibits multiple biological effects, especially its outstanding anti-HIV activity, which has drawn the attentions of many pharmacists. Among the derivatives of betulinic acid, some compounds exhibited inhibitory activities at the nanomolar concentrati...
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