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Fabiana H. G. Farias
Science for Life Laboratory
16Publications
9H-index
317Citations
Publications 16
Newest
OBJECTIVE To evaluate the coding regions of ADAMTS17 for potential mutations in Chinese Shar-Pei with a diagnosis of primary open-angle glaucoma (POAG), primary lens luxation (PLL), or both. ANIMAL...
6 CitationsSource
The risk allele A of rs200395694 associated with SLE in Swedish patients affects on MEF2D gene regulation and alternative splicing
#1Brita Ardesjö-Lundgren (SLU: Swedish University of Agricultural Sciences)H-Index: 2
#2Katarina Tengvall (KI: Karolinska Institutet)H-Index: 7
Last.Goran Andersson (SLU: Swedish University of Agricultural Sciences)H-Index: 64
view all 8 authors...
Background - Canine atopic dermatitis (CAD) is an inflammatory and pruritic allergic skin disease caused by interactions between genetic and environmental factors. Previously, a genome-wide signifi ...
1 CitationsSource
#1Katarina Tengvall (Science for Life Laboratory)H-Index: 7
#2Sergey V. Kozyrev (Science for Life Laboratory)H-Index: 14
Last.Kerstin Lindblad-Toh (Broad Institute)H-Index: 70
view all 14 authors...
Background: Canine atopic dermatitis (CAD) is a chronic inflammatory skin disease triggered by allergic reactions involving IgE antibodies directed towards environmental allergens. We previously id ...
2 CitationsSource
#1Daniel Eriksson (KI: Karolinska Institutet)H-Index: 4
#2Matteo Bianchi (Science for Life Laboratory)H-Index: 4
Last.Gerli Pielberg (Science for Life Laboratory)H-Index: 17
view all 30 authors...
BACKGROUND: Autoimmune disease is one of the leading causes of morbidity and mortality worldwide. In Addison's disease, the adrenal glands are targeted by destructive autoimmunity. Despite being th ...
11 CitationsSource
#1Katarina TengvallH-Index: 7
#2Sergey V. KozyrevH-Index: 14
view all 14 authors...
Source
#1Maria Wilbe (SLU: Swedish University of Agricultural Sciences)H-Index: 7
#2Sergey V. Kozyrev (Science for Life Laboratory)H-Index: 14
Last.Kerstin Lindblad-Toh (Broad Institute)H-Index: 70
view all 13 authors...
The complexity of clinical manifestations commonly observed in autoimmune disorders poses a major challenge to genetic studies of such diseases. Systemic lupus erythematosus (SLE) affects humans as well as other mammals, and is characterized by the presence of antinuclear antibodies (ANA) in patients’ sera and multiple disparate clinical features. Here we present evidence that particular sub-phenotypes of canine SLE-related disease, based on homogenous (ANAH) and speckled ANA (ANAS) staining pat...
12 CitationsSource
#1Katarina TengvallH-Index: 7
#2Sergey V. KozyrevH-Index: 14
Last.Kerstin Lindblad-TohH-Index: 70
view all 13 authors...
This thesis presents genetic studies of atopic dermatitis (AD) and IgA deficiency in dogs.AD is a chronic inflammatory and pruritic skin disorder caused by allergic reactions against environmental allergens. Both genetic and environmental factors are involved in the development of Canine AD (CAD) and human AD. In Paper I, we performed genome-wide association studies (GWAS) and identified a locus on chromosome 27 significantly associated with CAD in German shepherd dogs (GSDs). The locus contains...
#2Maria WilbeH-Index: 7
Last.Kerstin Lindblad-TohH-Index: 70
view all 9 authors...
High-Throughput Sequencing of 219 Candidate Genes for Identification of SLE-Associated Risk Variants
#1Katarina Tengvall (Science for Life Laboratory)H-Index: 7
#2Marcin Kierczak (SLU: Swedish University of Agricultural Sciences)H-Index: 10
Last.Kerstin Lindblad-Toh (Broad Institute)H-Index: 70
view all 13 authors...
Humans and dogs are both affected by the allergic skin disease atopic dermatitis (AD), caused by an interaction between genetic and environmental factors. The German shepherd dog (GSD) is a high-risk breed for canine AD (CAD). In this study, we used a Swedish cohort of GSDs as a model for human AD. Serum IgA levels are known to be lower in GSDs compared to other breeds. We detected significantly lower IgA levels in the CAD cases compared to controls (p = 1.1 × 10(-5)) in our study population. We...
42 CitationsSource
12