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Hanna Maja Tunset
Norwegian University of Science and Technology
4Publications
2H-index
17Citations
Publications 4
Newest
#1Michael G. Chiorazzo (UPenn: University of Pennsylvania)H-Index: 2
#2Hanna Maja Tunset (NTNU: Norwegian University of Science and Technology)H-Index: 2
Last.E. James Delikatny (UPenn: University of Pennsylvania)H-Index: 11
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Cytosolic phospholipase A2α (cPLA2α) has been shown to be elevated in breast cancer and is a potential biomarker in the differentiation of molecular sub-types. Using a cPLA2α activatable fluorophore, DDAO arachidonate, we explore its ability to function as a contrast agent in fluorescence-guided surgery. In cell lines ranging in cPLA2α expression and representing varying breast cancer sub-types, we show DDAO arachidonate activates with a high correlation to cPLA2α expression level. Using a contr...
#1Maria T. Grinde (NTNU: Norwegian University of Science and Technology)H-Index: 4
#2Bylgja Hilmarsdottir (University of Oslo)H-Index: 6
Last.Siver Andreas Moestue (NTNU: Norwegian University of Science and Technology)H-Index: 13
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Introduction Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 has shown promising effects in preclinical experiments and is currently undergoing clinical trials in several human malignancies, including triple-negative breast cancer (TNBC). However, response to glutaminase inhibitors is variable and there is a need for identification of pre...
Metastatic disease is the leading cause of death in breast cancer patients. Disrupting the cancer cell’s ability to migrate may be a strategy for hindering metastasis. Cytosolic phospholipase A2 α (cPLA2α), along with downstream proinflammatory and promigratory metabolites, has been implicated in several aspects of tumorigenesis, as well as metastasis, in various types of cancer. In this study, we aim to characterize the response to reduced cPLA2α activity in metastatic versus non-metastatic cel...
#1Matti W. Leino (Stockholm University)H-Index: 10
#2Svein Ø. SolbergH-Index: 2
Last.Jenny Hagenblad (Linköping University)H-Index: 14
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Multiplying onion (Allium cepa L. Aggregatum-Group), commonly known as shallot or potato onion, has a long tradition of cultivation in Fennoscandian home gardens. During the last decades, more than 80 accessions, maintained as vegetatively propagated clones, have been gathered from home gardens in all Fennoscandian countries. A genetic analysis showed regional patterns of accessions belonging to the same genetic group. However, accessions belonging to the same genetic group could originate in an...
#1Eugene Kim (NTNU: Norwegian University of Science and Technology)H-Index: 10
#2Hanna Maja Tunset (NTNU: Norwegian University of Science and Technology)H-Index: 2
Last.Siver Andreas Moestue (NTNU: Norwegian University of Science and Technology)H-Index: 13
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Background Group IVA cytosolic phospholipase A2 (cPLA2α) plays an important role in tumorigenesis and angiogenesis. It is overexpressed in basal-like breast cancer (BLBC), which is aggressive and usually triple-negative, making it unresponsive to current targeted therapies. Here, we evaluated the anti-angiogenic effects of a specific cPLA2α inhibitor, AVX235, in a patient-derived triple-negative BLBC model.
#1Syed Majid Bukhari (CUI: COMSATS Institute of Information Technology)H-Index: 3
#2Astrid Jullumstrø Feuerherm (University of the Sciences)H-Index: 8
Last.Erik Fuglset (University of the Sciences)H-Index: 1
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The activation of PLA 2 by means of pro-inflammatory cytokines results in the subsequent release of arachidonic acid (AA) and generates eicosanoids, which further propagate inflammation. By 6the cyclooxygenases (COX1/2) responsible for the enzymatic conversion of AA to eicosanoids, the non-steroidal anti-inflammatory drugs are effective in relieving the pain and discomfort of inflammation. By using AA release assay as a guide for biological and anti-inflammatory activity, novel compound 1- O -(3...
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