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Chun Y. Wong
Curtin University
BioavailabilityChemistryOral administrationInsulinDrug delivery
5Publications
5H-index
104Citations
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Publications 10
Newest
#1Chun Y. Wong (Curtin University)H-Index: 5
#2Hani Al-Salami (Curtin University)H-Index: 22
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 3 authors...
Abstract A successful oral protein nanocarrier needs to exhibit the following characteristics: stability in the gastrointestinal (GI) tract, drug release at specific site, overcoming high mucus turnover, mucoadhesive properties and enhanced epithelial absorption. The purpose of this research was to examine the potential of complex coacervation technique for manufacturing of insulin-loaded chitosan-Dz13Scr nanoparticles. The nanoparticles were characterized for size, polydispersity index, entrapm...
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#1Chun Y. Wong (Curtin University)H-Index: 5
#2Hani Al-Salami (Curtin University)H-Index: 22
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 3 authors...
Oral delivery of insulin-loaded therapeutics is challenging due to the extreme pH condition, enzymatic degradation, and limited permeation in the gastrointestinal (GI) tract. Nanoparticles can overcome various GI barriers and improve the oral bioavailability of insulin. Although a number of novel strategies have been reported to optimise the orally administered nano-formulation, its clinical translation remains unachievable. Animal studies are essential to establish the protective effect, transi...
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#1Chun Y. Wong (Curtin University)H-Index: 5
#2Hani Al-SalamiH-Index: 22
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 3 authors...
The oral bioavailability of therapeutic proteins is limited by the gastrointestinal barriers. Encapsulation of labile proteins into nanoparticles is a promising strategy. In order to improve the stability of nanoparticles, lyophilisation has been used to remove water molecules from the suspension. Although various cryoprotections were employed in the preparation of lyophilised nanoparticles, the selection of cryoprotectant type and concentration in majority of the developed formulation was not j...
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#1Chun Y. Wong (Curtin University)H-Index: 5
#2Hani Al-Salami (Curtin University)H-Index: 22
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 3 authors...
AbstractCellular assays are essential in pharmaceutical development of protein-loaded nanomedicine. Cell lines provide robust and efficient models to characterise cytotoxicity, cellular uptake, abs...
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#1Chun Y. Wong (Curtin University)H-Index: 5
#2Giuseppe Luna (Curtin University)H-Index: 4
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 5 authors...
Abstract Therapeutic proteins are labile macromolecules that are prone to degradation during production, freeze-drying and storage. Recent studies showed that nanoparticles can enhance the stability and oral bioavailability of encapsulated proteins. Several conventional approaches (enzyme inhibitors, mucoadhesive polymers) and novel strategies (surface modification, ligand conjugation, flash nano-complexation, stimuli-responsive drug delivery systems) have been employed to improve the physiochem...
4 CitationsSource
#1Chun Y. Wong (Curtin University)H-Index: 5
#2Hani Al-Salami (Curtin University)H-Index: 22
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 3 authors...
Abstract Diabetes mellitus is a chronic metabolic health disease affecting the homeostasis of blood sugar levels. However, subcutaneous injection of insulin can lead to patient non-compliance, discomfort, pain and local infection. Sub-micron sized drug delivery systems have gained attention in oral delivery of insulin for diabetes treatment. In most of the recent literature, the terms “microparticles” and “nanoparticle” refer to particles where the dimensions of the particle are measured in micr...
24 CitationsSource
#1Chun Y. Wong (Curtin University)H-Index: 5
#2Hani Al-Salami (Curtin University)H-Index: 22
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 3 authors...
AbstractTherapeutic peptides are conventionally administered via subcutaneous injection. Chitosan-based nanoparticles are gaining increased attention for their ability to serve as a carrier for oral delivery of peptides and vaccination. They offered superior biocompatibiltiy, controlled drug release profile and facilitated gastrointestinal (GI) absorption. The encapsulated peptides can withstand enzymatic degradation and various pH. Chitosan-based nanoparticles can also be modified by ligand con...
11 CitationsSource
#1Chun Y. Wong (Curtin University)H-Index: 5
#2Hani Al-Salami (Curtin University)H-Index: 22
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 3 authors...
Abstract Nanoparticles have demonstrated significant advancements in potential oral delivery of insulin. In this publication, we review the current status of polymeric, inorganic and solid-lipid nanoparticles designed for oral administration of insulin. Firstly, the structure and physiological function of insulin are examined. Then, the efficiency and shortcomings of insulin nanoparticle are discussed. These include the susceptibility to digestive enzyme degradation, instability in the acidic pH...
27 CitationsSource
#1Chun Y. Wong (Curtin University)H-Index: 5
#2Jorge Martinez (Curtin University)H-Index: 5
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 4 authors...
Objectives The aim of this study was to develop an enteric coated insulin tablet formulation using polymers, absorption enhancer and enzyme inhibitor, which protect the tablets in acidic pH and enhance systemic bioavailability. Methods In this study, the influence of coating by cellulose acetate hydrogen phthalate solution and chosen excipients on Glut-4 transporter translocation in C2C12 skeletal muscle cells was examined. Following the determination of optimum number of coating layers, two dis...
6 CitationsSource
#1Chun Y. Wong (Curtin University)H-Index: 5
#2Jorge Martinez (Curtin University)H-Index: 5
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 3 authors...
Objectives Diabetes mellitus is characterised by progressive β-cell destruction and loss of function, or loss of ability of tissues to respond to insulin. Daily subcutaneous insulin injection is standard management for people with diabetes, although patient compliance is hard to achieve due to the inconvenience of injections, so other forms of delivery are being tested, including oral administration. This review summarises the developments in oral insulin administration. Methods The PubMed datab...
36 CitationsSource
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