Nathaniel Marchetti
Temple University
Intensive care medicinePhysical therapyCOPDLungMedicine
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Publications 128
#1Mark T. Dransfield (UAB: University of Alabama at Birmingham)H-Index: 41
#2Justin L. GarnerH-Index: 2
Last. Shawn E. Wright (St. Joseph's Hospital and Medical Center)H-Index: 3
view all 18 authors...
RATIONALE: Bronchoscopic Lung Volume Reduction (BLVR) with Zephyr(R) Valves improves lung function, exercise tolerance and quality of life (QoL) of patients with hyperinflated emphysema and little to no collateral ventilation (CV). OBJECTIVES: Post-hoc analysis of patient reported outcomes (PROs) including multidimensional measures of dyspnea, activity, and QoL in the LIBERATE Study are reported. METHODS: 190 patients with severe heterogeneous emphysema and little to no CV in the target lobe wer...
#1Amarnath S. Marudamuthu (University of Texas Health Science Center at Tyler)H-Index: 10
#2Yashodhar P. Bhandary (University of Texas Health Science Center at Tyler)H-Index: 13
Last. Sreerama Shetty (University of Texas Health Science Center at Tyler)H-Index: 25
view all 18 authors...
Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disease with a median 5-year survival of ~20%. Current U.S. Food and Drug Administration–approved pharmacotherapies slow progression of IPF, providing hope that even more effective treatments can be developed. Alveolar epithelial progenitor type II cell (AEC) apoptosis and proliferation, and accumulation of activated myofibroblasts or fibrotic lung fibroblasts (fLfs) contribute to the progression of IPF. Full-length caveolin-1 scaffold...
#1Chih-Ru Lin (TU: Temple University)H-Index: 2
#2Karim Bahmed (TU: Temple University)H-Index: 4
Last. Beata Kosmider (TU: Temple University)H-Index: 14
view all 9 authors...
Pulmonary emphysema is characterized by alveolar type II (ATII) cell death, destruction of alveolar wall septa, and irreversible airflow limitation. Cigarette smoke induces oxidative stress and is ...
1 CitationsSource
Background: Chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality. Present-day diagnostic criteria are largely based solely on spirometric criteria. Accumulating evidence has identified a substantial number of individuals without spirometric evidence of COPD who suffer from respiratory symptoms and/or increased morbidity and mortality. There is a clear need for an expanded definition of COPD that is linked to physiologic, structural (computed tomography [C...
#1Chandra DassH-Index: 7
#2Farouk DakoH-Index: 2
Last. Gj. CrinerH-Index: 63
view all 6 authors...
#1Victor Kim (TU: Temple University)H-Index: 23
#2H. Zhao (TU: Temple University)H-Index: 4
Last. Mario E. RuizH-Index: 5
view all 152 authors...
Background Chronic bronchitis (CB) increases risk of COPD exacerbations. We have shown that the St. George’s Respiratory Questionnaire (SGRQ) CB definition identifies patients with a similar clinical phenotype as classically defined CB. Whether the SGRQ CB definition is a predictor of future COPD exacerbations is unknown. Methods We analyzed 7,557 smokers with normal spirometry and Global Initiative for Chronic Obstructive Lung Disease stage 1-4 COPD in the Genetic Epidemiology of COPD study wit...
1 CitationsSource
#1A. Gangemi (TU: Temple University)H-Index: 1
#2Catherine N. Myers (TU: Temple University)
Last. A. James Mamary (TU: Temple University)H-Index: 9
view all 10 authors...
Abstract Rationale Sarcoidosis progresses to end stage fibrotic lung disease in 10% of patients and may necessitate lung transplantation. Organ allocation is currently determined by the Lung Allocation Score (LAS), but its performance in a sarcoidosis population has not been evaluated. Objectives To determine sarcoidosis-specific wait list mortality and identify predictive factors of death on the transplantation wait list. Methods This was a single-center retrospective study of all sarcoidosis p...
#1Silvia Moimas (International Centre for Genetic Engineering and Biotechnology)H-Index: 12
#2Francesco SaltonH-Index: 3
Last. Marco Confalonieri (UniTS: University of Trieste)H-Index: 28
view all 17 authors...
Rationale Alveolar type II (ATII) cells act as adult stem cells contributing to alveolar type I (ATI) cell renewal and play a major role in idiopathic pulmonary fibrosis (IPF), as supported by familial cases harbouring mutations in genes specifically expressed by these cells. During IPF, ATII cells lose their regenerative potential and aberrantly express pathways contributing to epithelial–mesenchymal transition (EMT). The microRNA miR-200 family is downregulated in IPF, but its effect on human ...
#1Mark T. Dransfield (UAB: University of Alabama at Birmingham)H-Index: 41
#2Surya P. Bhatt (UAB: University of Alabama at Birmingham)H-Index: 24
Last. Gerard J. Criner (TU: Temple University)H-Index: 64
view all 11 authors...
Introduction: Bronchoscopic Lung Volume Reduction (BLVR) with the Zephyr® Valve improves lung function, exercise tolerance and quality of life in hyperinflated emphysema patients with little to no collateral ventilation (CV). Here we report further analysis of the impact of BLVR on patient reported outcomes (PROs) in the LIBERATE Study. Methods: 190 severe heterogeneous emphysema subjects were randomized 2:1 (Zephyr Valve to Standard of Care (SOC)) at 24 centers. Subjects were 53% female and had...