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Robert M. Lust
East Carolina University
EndocrinologyCardiologyDiabetes mellitusMedicineBiology
84Publications
18H-index
1,417Citations
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Publications 102
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#1Andrew Kisling (ECU: East Carolina University)H-Index: 1
#2Robert M. Lust (ECU: East Carolina University)H-Index: 18
Last. Laxmansa C. Katwa (ECU: East Carolina University)H-Index: 10
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Abstract Collagen is the most abundant protein in mammalian systems; it can be found in organs such as bones, the liver, kidney, heart, teeth, and skin. Collagen provides the necessary structural framework for tissues in which it is found. However, if there are any alterations in the delicate balance of collagen types in the extracellular matrix (ECM), then problems arise. For example, increasing collagen I:III ratio would provide additional rigidity to tissue structure, whereas decreasing this ...
1 CitationsSource
#1Leslie C. Thompson (ECU: East Carolina University)H-Index: 6
#2Nicole L. Sheehan (ECU: East Carolina University)
Last. Christopher J. Wingard (Bellarmine University)H-Index: 1
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The broad list of commercial applications for multi-walled carbon nanotubes (MWCNT) can be further expanded with the addition of various surface chemistry modifications. For example, standard commercial grade MWCNT (C-grade) can be carboxylated (COOH) or nitrogen-doped (N-doped) to suite specific utilities. We previously reported dose-dependent expansions of cardiac ischemia/reperfusion (I/R) injury, 24 h after intratracheal instillation of C-grade, COOH, or N-doped MWCNT in mice. Here, we have ...
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#1Madaniah Zakari (Taibah University)
#2Musaad Alsahly (ECU: East Carolina University)
Last. Robert M. Lust (ECU: East Carolina University)H-Index: 18
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Substantial evidence exists indicating that regular exercise is essential in the promotion of health and treatment of disease. In fact, overwhelming evidence from various studies has revealed that regular exercise enhances both the quality of life was well as the life expectancy of an individual, and for that reason, exercise is now referred to as a “medicine”; as a drug. Yet, a significant subset of the population dies not respond to exercise, and in some settings, the stress induced by exercis...
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#1Nathan A. Holland (ECU: East Carolina University)H-Index: 7
#2Robert M. Lust (ECU: East Carolina University)H-Index: 18
Last. David A. Tulis (ECU: East Carolina University)H-Index: 17
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Introduction: The genotype associated with an inducible response to dynamic exercise is different from the genotype associated with the intrinsic capacity for aerobic exercise. The inducible response is an established component of rehab protocols after ischemic events, but the influence of the intrinsic capacity for exercise on the vascular response to active exercise following ischemic injury is unknown. Hypothesis: Reduced intrinsic aerobic exercise capacity will limit the early (2 week) induc...
#1Andrew W. Holt (ECU: East Carolina University)H-Index: 3
#2Danielle N. Martin (ECU: East Carolina University)H-Index: 4
Last. David A. Tulis (ECU: East Carolina University)H-Index: 17
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Coronary artery disease (CAD) accounts for over half of all cardiovascular disease-related deaths. Uncontrolled arterial smooth muscle (ASM) cell migration is a major component of CAD pathogenesis and efforts aimed at attenuating its progression are clinically essential. Cyclic nucleotide signaling has long been studied for its growth-mitigating properties in the setting of CAD and other vascular disorders. Heme-containing soluble guanylyl cyclase (sGC) synthesizes cyclic guanosine monophosphate...
10 CitationsSource
#1Surovi HazarikaH-Index: 5
Last. Robert M. LustH-Index: 18
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#1Nathan A. Holland (ECU: East Carolina University)H-Index: 7
#2Leslie C. Thompson (ECU: East Carolina University)H-Index: 6
Last. Christopher J. Wingard (ECU: East Carolina University)H-Index: 25
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Background The uses of engineered nanomaterials have expanded in biomedical technology and consumer manufacturing. Furthermore, pulmonary exposure to various engineered nanomaterials has, likewise, demonstrated the ability to exacerbate cardiac ischemia reperfusion (I/R) injury. However, the influence of particle size or capping agent remains unclear. In an effort to address these influences we explored response to 2 different size gold core nanosilver particles (AgNP) with two different capping...
10 CitationsSource
#1Nathan A. Holland (ECU: East Carolina University)H-Index: 7
#2Gregory Harris (ECU: East Carolina University)H-Index: 3
Last. Christopher J. Wingard (ECU: East Carolina University)H-Index: 25
view all 4 authors...
2 Citations
#1Jitka A. I. Virag (ECU: East Carolina University)H-Index: 13
#2Robert M. Lust (ECU: East Carolina University)H-Index: 10
Components of circadian rhythm maintenance, or “clock genes,” are endogenous entrainable oscillations of about 24 h that regulate biological processes and are found in the suprachaismatic nucleus (SCN) and many peripheral tissues, including the heart. They are influenced by external cues, or Zeitgebers, such as light and heat, and can influence such diverse phenomena as cytokine expression immune cells, metabolic activity of cardiac myocytes, and vasodilator regulation by vascular endothelial ce...
13 CitationsSource
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