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Maurizio Viale
National Cancer Research Institute
103Publications
20H-index
1,255Citations
Publications 105
Newest
#1Maurizio VialeH-Index: 20
#2Graziella Vecchio (University of Catania)H-Index: 29
Last.Mattia RoccoH-Index: 23
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Abstract In vivo local antitumor activity of fibrin gels (FBGs) loaded with the poly-cyclodextrin oCD-NH2/Dox, compared to FBGs loaded with doxorubicin (Dox) or to free Dox, was evaluated in two mouse orthotopic neuroblastoma (NB) models, after positioning of the releasing devices in the visceral space. FBGs were prepared at the fibrinogen (FG) concentrations of 22 and 40 mg/ml clotted in the presence of 0.81 mM/mg FG Ca2+ and 1.32 U/mg FG thrombin. Our results indicate that FBGs loaded with oCD...
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#2Maurizio VialeH-Index: 20
Last.Graziella VecchioH-Index: 29
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#1Maurizio VialeH-Index: 20
#2Rita TostoH-Index: 2
Last.Graziella VecchioH-Index: 29
view all 8 authors...
Polymeric cyclodextrin–based nanoparticles are currently undergoing clinical trials as nanotherapeutics. Using a non-covalent approach, we decorated two cross-linked cyclodextrin polymers of different molecular weights with an RGD peptide derivative to construct a novel carrier for the targeted delivery of doxorubicin. RGD is the binding sequence for the integrin receptor family that is highly expressed in tumour tissues. The assembled host–guest systems were investigated using NMR and DLS techn...
2 CitationsSource
#1Maurizio VialeH-Index: 20
#2Graziella Vecchio (University of Catania)H-Index: 29
Last.Mattia RoccoH-Index: 23
view all 12 authors...
Purpose Fibrin gels (FBGs) are potential delivery vehicles for many drugs, and can be easily prepared from purified components. We previously demonstrated their applicability for the release of different doxorubicin (Dox) nanoparticles used clinically or in an experimental stage, such as its inclusion complex with the amino β-cyclodextrin polymer (oCD-NH2/Dox). Here we extend these studies by in vitro and in vivo evaluations.
1 CitationsSource
Source
#1Valentina GiglioH-Index: 5
#2Maurizio VialeH-Index: 20
Last.Graziella VecchioH-Index: 29
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Polymeric nanoparticles based on cyclodextrins are currently undergoing clinical trials as new promising nanotherapeutics. In light of this interest, we investigated cyclodextrin cross-linked polymers with different lengths as carriers for the poorly water-soluble drug sorafenib. Both polymers significantly enhanced sorafenib solubility, with shorter polymers showing the most effective solubilizing effect. Inclusion complexes between sorafenib and the investigated polymers exhibited an antiproli...
4 CitationsSource
#1Maurizio VialeH-Index: 20
Last.Mattia RoccoH-Index: 23
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Abstract Background Local delivery of anticancer drugs represents a desirable type of treatment. Nevertheless, characteristics such as availability, biocompatibility, ease of operation, and efficacy sometimes represent difficult to overcome hurdles. Fibrin gels (FBGs) may be attractive biomaterials for local treatment when loaded with different chemotherapeutics or with polymer-anticancer-drug conjugates and nanoparticles. These components, linked together, might represent candidates to countera...
4 CitationsSource
#1Paola Bonaccorsi (UNIME: University of Messina)H-Index: 17
#2Teresa Papalia (UNIME: University of Messina)H-Index: 8
Last.Fausto Puntoriero (UNIME: University of Messina)H-Index: 30
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We prepared a bichromophoric species 1, made of two different bodipy dyes bridged by a D-galactose unit. 1 exhibits different emission spectra when located in different compartments of biological systems, independently of its concentration. This is an unprecedented feature for a single multicomponent molecule and is due to the dependence on the environment of the photoinduced energy transfer process occurring between its bodipy subunits. Therefore, 1 can give useful information about cell compos...
1 CitationsSource
#1Valentina Oliveri (University of Catania)H-Index: 13
#2Federica Bentivegna (University of Catania)
Last.Graziella Vecchio (University of Catania)H-Index: 29
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8-Hydroxyquinolines show a wide range of pharmacological activities, and some are marketed as therapeutic agents. Despite the significant number of biologically active hydroxyquinolines proposed, there is a continued interest in the development of new active derivatives to overcome the drawbacks associated with their use. Herein, we report the synthesis and characterization of a set of positional isomers of hydroxyquinoline–mannose conjugates. Since in many cases the complexation ability of 8-hy...
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#1Valentina OliveriH-Index: 13
#2Francesco BelliaH-Index: 18
Last.Graziella VecchioH-Index: 29
view all 5 authors...
Abstract Cyclodextrins have been used to encapsulate drugs improving their stability and efficiently regulating their release. Polymeric nanoparticles containing cyclodextrins are currently undergoing clinical trials as nanotherapeutics. In this context, we have synthesized new linear polymers based on polyglutamic acid with pendant β- or γ-cyclodextrins, using a high yield reaction route. The new polymers with an average number of about 17 cyclodextrin cavities were characterized (NMR, MALDI-MS...
7 CitationsSource
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