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Crispin R. Dass
Curtin University
CancerOsteosarcomaCancer researchMedicineBiology
220Publications
44H-index
8,853Citations
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Publications 232
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#1Chun Y. Wong (Curtin University)H-Index: 5
#2Hani Al-Salami (Curtin University)H-Index: 22
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 3 authors...
Abstract A successful oral protein nanocarrier needs to exhibit the following characteristics: stability in the gastrointestinal (GI) tract, drug release at specific site, overcoming high mucus turnover, mucoadhesive properties and enhanced epithelial absorption. The purpose of this research was to examine the potential of complex coacervation technique for manufacturing of insulin-loaded chitosan-Dz13Scr nanoparticles. The nanoparticles were characterized for size, polydispersity index, entrapm...
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#1Chun Y. Wong (Curtin University)H-Index: 5
#2Hani Al-Salami (Curtin University)H-Index: 22
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 3 authors...
Oral delivery of insulin-loaded therapeutics is challenging due to the extreme pH condition, enzymatic degradation, and limited permeation in the gastrointestinal (GI) tract. Nanoparticles can overcome various GI barriers and improve the oral bioavailability of insulin. Although a number of novel strategies have been reported to optimise the orally administered nano-formulation, its clinical translation remains unachievable. Animal studies are essential to establish the protective effect, transi...
Source
#1Chun Y. Wong (Curtin University)H-Index: 5
#2Hani Al-SalamiH-Index: 22
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 3 authors...
The oral bioavailability of therapeutic proteins is limited by the gastrointestinal barriers. Encapsulation of labile proteins into nanoparticles is a promising strategy. In order to improve the stability of nanoparticles, lyophilisation has been used to remove water molecules from the suspension. Although various cryoprotections were employed in the preparation of lyophilised nanoparticles, the selection of cryoprotectant type and concentration in majority of the developed formulation was not j...
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#1Sangeetha Mathavan (Curtin University)H-Index: 5
Last. Hani Al-Salami (Curtin University)H-Index: 22
view all 8 authors...
Aim: Gliclazide (G) is a drug prescribed for Type 2 diabetics, although recent studies suggest it has desirable effects in both types of diabetes, Type 1 diabetes and Type 2 diabetes. G has an inco...
1 CitationsSource
#1Chun Y. Wong (Curtin University)H-Index: 5
#2Hani Al-Salami (Curtin University)H-Index: 22
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 3 authors...
AbstractCellular assays are essential in pharmaceutical development of protein-loaded nanomedicine. Cell lines provide robust and efficient models to characterise cytotoxicity, cellular uptake, abs...
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#1Naomi Brook (Curtin University)H-Index: 1
#2Emily Brook (Curtin University)H-Index: 3
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 5 authors...
Abstract Pigment epithelium-derived factor (PEDF) is an endogenous human glycoprotein first identified as a neurotrophic factor in retinal pigmented epithelium cells. PEDF has since been shown to play a central role in mediating cellular protection against oxidative stress, by promoting cell survival, reducing inflammation, and inhibiting pathological angiogenesis in a range of cell types and tissues. PEDF is a well-established neurotrophic factor which supports neurogenesis and provides neuropr...
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#1Ahmed Gedawy (Curtin University)H-Index: 2
#2Hani Al-Salami (Curtin University)H-Index: 22
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 3 authors...
Abstract The antidiabetic drugs metformin, gliclazide and glipizide have been widely used and studied in terms of pharmacological and antidiabetic effects, and their individual stability has been studied in the literature. However, the drugs’ combined stability profiling remains poorly understood, and hence the aim of this study was to investigate the collective stability profiling of different combinations at various controlled conditions. Degradation assessments were carried out on metformin, ...
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#1Naomi Brook (Curtin University)H-Index: 1
#2Emily Brook (Curtin University)H-Index: 3
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 5 authors...
AbstractSince its discovery as a neurotrophic factor in retinal pigmented epithelium cells in the late 1980s, there has been an increase in understanding of the role that pigment epithelium-derived...
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#1Chun Y. Wong (Curtin University)H-Index: 5
#2Giuseppe Luna (Curtin University)H-Index: 4
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 5 authors...
Abstract Therapeutic proteins are labile macromolecules that are prone to degradation during production, freeze-drying and storage. Recent studies showed that nanoparticles can enhance the stability and oral bioavailability of encapsulated proteins. Several conventional approaches (enzyme inhibitors, mucoadhesive polymers) and novel strategies (surface modification, ligand conjugation, flash nano-complexation, stimuli-responsive drug delivery systems) have been employed to improve the physiochem...
4 CitationsSource
#1Sangeetha Mathavan (Curtin University)H-Index: 5
Last. Hani Al-Salami (Curtin University)H-Index: 22
view all 8 authors...
Aim: Recent studies suggest potential applications of endogenously produced human bile acids as formulation-excipient and drug tissue permeation enhancers in Type 1 diabetes. We aimed to examine th...
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