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Jorge Martinez
Curtin University
ChemistryInsulinBile acidChromatographyBiochemistry
7Publications
5H-index
115Citations
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Publications 10
Newest
#1Chun Y. Wong (Curtin University)H-Index: 5
#2Giuseppe Luna (Curtin University)H-Index: 4
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 5 authors...
Abstract Therapeutic proteins are labile macromolecules that are prone to degradation during production, freeze-drying and storage. Recent studies showed that nanoparticles can enhance the stability and oral bioavailability of encapsulated proteins. Several conventional approaches (enzyme inhibitors, mucoadhesive polymers) and novel strategies (surface modification, ligand conjugation, flash nano-complexation, stimuli-responsive drug delivery systems) have been employed to improve the physiochem...
4 CitationsSource
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#1Chun Yuen Wong (Curtin University)H-Index: 1
#2Jorge Martinez (Curtin University)H-Index: 5
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 4 authors...
Therapeutic proteins are administered subcutaneously because of their instability in the gastrointestinal tract. Current research suggests that polymeric-based nanoparticles, microparticles and liposomes are ideal nanocarriers to encapsulate proteins for disease management. In order to develop a successful drug delivery system, it is crucial to determine drug release profile and stability. However, the non-active excipients in polymeric formulations can influence the quantification of proteins i...
1 CitationsSource
#1Ahmed Gedawy (Curtin University)H-Index: 2
#2Jorge Martinez (Curtin University)H-Index: 5
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 4 authors...
14 CitationsSource
#1Chun Y. Wong (Curtin University)H-Index: 5
#2Jorge Martinez (Curtin University)H-Index: 5
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 4 authors...
Objectives The aim of this study was to develop an enteric coated insulin tablet formulation using polymers, absorption enhancer and enzyme inhibitor, which protect the tablets in acidic pH and enhance systemic bioavailability. Methods In this study, the influence of coating by cellulose acetate hydrogen phthalate solution and chosen excipients on Glut-4 transporter translocation in C2C12 skeletal muscle cells was examined. Following the determination of optimum number of coating layers, two dis...
6 CitationsSource
#1Chun Y. Wong (Curtin University)H-Index: 5
#2Jorge Martinez (Curtin University)H-Index: 5
Last. Crispin R. Dass (Curtin University)H-Index: 44
view all 3 authors...
Objectives Diabetes mellitus is characterised by progressive β-cell destruction and loss of function, or loss of ability of tissues to respond to insulin. Daily subcutaneous insulin injection is standard management for people with diabetes, although patient compliance is hard to achieve due to the inconvenience of injections, so other forms of delivery are being tested, including oral administration. This review summarises the developments in oral insulin administration. Methods The PubMed datab...
36 CitationsSource
#1P. LeeH-Index: 1
#2Jorge MartinezH-Index: 5
Last. Crispin R. DassH-Index: 44
view all 3 authors...
2 CitationsSource
AbstractIntroduction: In previous studies, we have shown that a gliclazide–cholic acid derivative (G–CA) mixture resulted in an enhanced ileal permeation of G (ex vivo). When administered orally to diabetic rats, it brought about a significant hypoglycaemic effect. In this study, we aim to create a novel microencapsulated-formulation of G–CA with uniform and coherent structure that can be further tested in our rat model of type 1 diabetes (T1D). We also aim to examine the effect of CA addition t...
28 CitationsSource
#1Armin Mooranian (Curtin University)H-Index: 17
#2Rebecca Negrulj (Curtin University)H-Index: 17
Last. Hani Al-Salami (Curtin University)H-Index: 22
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Introduction In previous studies carried out in our laboratory, a bile acid (BA) formulation exerted a hypoglycaemic effect in a rat model of type-1 diabetes (T1D). When the antidiabetic drug gliclazide (G) was added to the bile acid, it augmented the hypoglycaemic effect. In a recent study, we designed a new formulation of gliclazide-cholic acid (G-CA), with good structural properties, excipient compatibility and exhibits pseudoplastic-thixotropic characteristics. The aim of this study is to te...
28 CitationsSource
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