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Ronald L. Korn
Translational Genomics Research Institute
CancerPathologyPancreatic cancerGemcitabineMedicine
66Publications
14H-index
1,394Citations
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Publications 71
Newest
#1Allyson J. Ocean (NewYork–Presbyterian Hospital)H-Index: 17
#2Ronald L. KornH-Index: 14
Last. Giuseppe Del Priore (Morehouse School of Medicine)H-Index: 1
view all 7 authors...
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#1Erkut BorazanciH-Index: 8
#2Gayle S. JamesonH-Index: 12
Last. Ronald L. KornH-Index: 14
view all 17 authors...
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#1Cynthia SirardH-Index: 8
#2Samuel J. KlempnerH-Index: 19
Last. Ronald L. KornH-Index: 14
view all 8 authors...
429Background: Dickkopf-1 (DKK1) modulates Wnt and PI3K/AKT signaling pathways and contributes to an immune suppressive tumor microenvironment. Recently, anti-DKK1 antibody (DKN-01) [D] plus pembro...
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#1Erkut BorazanciH-Index: 8
#2Ronald L. KornH-Index: 14
Last. Gayle S. JamesonH-Index: 12
view all 10 authors...
BACKGROUND: Molecular analysis has revealed four subtypes of pancreatic ductal adenocarcinoma (PDAC). One subtype identified for the presence of DNA damage repair deficiency can be targeted therapeutically with the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib. We performed a single institution retrospective analysis of treatment response in patients with PDAC treated with olaparib who have DNA damage repair deficiency mutations. SUBJECTS, MATERIALS, AND METHODS: Patients with germline ...
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#1Erkut Borazanci (TGen: Translational Genomics Research Institute)H-Index: 8
#2Gayle S. Jameson (TGen: Translational Genomics Research Institute)H-Index: 12
view all 16 authors...
Background: Localized PDAC management has recently evolved. Due to concerns over micrometastases at diagnosis, the use of neoadjuvant chemotherapy for PDAC has become more common. Typical therapies involve the use of multiagent systemic chemotherapy with or without radiation therapy. Cancer antigen 19-9 (CA 19-9) normalization in borderline resectable (BR) and locally advanced (LA) PDAC has been associated with greater OS. The addition of cisplatin (C) to gemcitabine (G) and paclitaxel protein b...
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#1Allyson J. Ocean (Cornell University)H-Index: 17
#2Marcus Noel (UR: University of Rochester)H-Index: 2
Last. Vincent J. Picozzi (Virginia Mason Medical Center)H-Index: 27
view all 9 authors...
Abstract Background SM-88 (D,L-alpha-metyrosine; racemetyrosine [USAN]) is a relatively non-toxic, targeted therapy based on the Warburg Effect. It may be well suited for pancreas cancer because of its ability to penetrate tumors and tolerability in compromised patients. Methods Subjects progressed on at least one line of chemotherapy were randomized to receive either 460 mg/d or 920 mg/d single agent SM-88 administered with low doses of methoxsalen, phenytoin, and sirolimus (MPS) in the dose se...
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#1Hani M. Babiker (UA: University of Arizona)H-Index: 8
#2Sara A. Byron (TGen: Translational Genomics Research Institute)H-Index: 16
Last. Michael S. GordonH-Index: 74
view all 23 authors...
Malignant melanoma (MM) exhibits a high propensity for central nervous system dissemination with ~50% of metastatic MM patients developing brain metastases (BM). Targeted therapies and immune checkpoint inhibitors have improved overall survival for MM patients with BM. However, responses are usually of short duration and new agents that effectively penetrate the blood brain barrier (BBB) are needed. Here, we report a MM patient with BM who experienced an exceptional response to E6201, an ATP-com...
1 CitationsSource
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#1Erkut BorazanciH-Index: 8
#2Gayle S. JamesonH-Index: 12
Last. Daniel D. Von HoffH-Index: 84
view all 9 authors...
Background: Effective therapy for the treatment of PDAC remains one of the greatest unmet oncology clinical needs. The addition of C to G and AP has shown promising clinical data in a previously reported study [J Clin Oncol 35, 2017 (suppl 4S; abstract 341)]. In preclinical work, vitamin D (Vit D) analog therapy decreases myeloid derived suppressor cells and regulatory T cells, favorably influencing the immune environment. This trial combines AP/C/G with Vit D analog P and the anti-PD-1 antibody...
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#1Rebecca F. Halperin (TGen: Translational Genomics Research Institute)H-Index: 14
#2Winnie S. Liang (TGen: Translational Genomics Research Institute)H-Index: 24
Last. Sara A. Byron (TGen: Translational Genomics Research Institute)H-Index: 16
view all 14 authors...
Archival tumor samples represent a rich resource of annotated specimens for translational genomics research. However, standard variant calling approaches require a matched normal sample from the same individual, which is often not available in the retrospective setting, making it difficult to distinguish between true somatic variants and individual-specific germline variants. Archival sections often contain adjacent normal tissue, but this tissue can include infiltrating tumor cells. As existing...
1 CitationsSource
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