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D. Ziegler
University of Düsseldorf
Publications 1
Published on May 8, 2003in Journal of Neurochemistry 4.87
D. Ziegler1
Estimated H-index: 1
(HHU: University of Düsseldorf)
Increased oxidative stress has been implicated in the pathogenesis of diabetic polyneuropathy (DPN). Antioxidant treatment with alpha-lipoic acid (ALA) has been shown to prevent or ameliorate experimental diabetic neuropathy, providing the rationale for treatment in humans. A recent meta-analysis including four controlled clinical trials provided evidence that treatment with ALA (600 mg/day i.v.) over 3 weeks is safe and significantly improves both neuropathic symptoms and deficits to a clinical...