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Jie Liao
Zhejiang University
Triple quadrupole mass spectrometerTraditional Chinese medicineAlternative medicineSelected reaction monitoringMedicine
4Publications
3H-index
18Citations
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Publications 8
Newest
#1Xin Shao (ZJU: Zhejiang University)H-Index: 3
#2Jie Liao (ZJU: Zhejiang University)H-Index: 3
Last. Xiaohui Fan (ZJU: Zhejiang University)H-Index: 24
view all 6 authors...
Summary Recent advancements in single-cell RNA sequencing (scRNA-seq) have facilitated the classification of thousands of cells through transcriptome profiling, wherein accurate cell-type identification is critical for mechanistic studies. In most of current analysis protocols, cell type-based cluster annotation is manually performed and heavily relies on prior knowledge, resulting in poor replicability of cell type annotation. This study aimed to introduce a single-cell Cluster-based automatic ...
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#1Rui XueH-Index: 1
#2Jie LiaoH-Index: 3
Last. Xiaohui FanH-Index: 24
view all 8 authors...
As one of the primary contributors to high clinical attrition rates of drugs, toxicity evaluation is of critical significance to new drug discovery. Unsurprisingly, a vast number of computational methods have been developed at various stages of development pipeline to evaluate potential adverse drug reactions (ADRs). Despite of previous success of these methods on individual ADR or certain drug family, it poses great challenges to toxicity evaluation. In this study, a novel strategy was develope...
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#1Zhenhao Li (ZJU: Zhejiang University)H-Index: 3
#2Xiaohui Zhang (ZJU: Zhejiang University)
Last. Yiyu Cheng (ZJU: Zhejiang University)H-Index: 31
view all 5 authors...
Abstract Chromatographic fingerprinting has been perceived as an essential tool for assessing quality and chemical equivalence of traditional Chinese medicine. However, this pattern-oriented approach still has some weak points in terms of chemical coverage and robustness. In this work, we proposed a multiple reaction monitoring (MRM)-based fingerprinting method in which approximately 100 constituents were simultaneously detected for quality assessment. The derivative MRM approach was employed to...
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#1Xin Shao (ZJU: Zhejiang University)H-Index: 3
#2Ning Lv (ZJU: Zhejiang University)H-Index: 2
Last. Xiaohui Fan (ZJU: Zhejiang University)H-Index: 24
view all 8 authors...
Background Cancer is a heterogeneous disease with many genetic variations. Lines of evidence have shown copy number variations (CNVs) of certain genes are involved in development and progression of many cancers through the alterations of their gene expression levels on individual or several cancer types. However, it is not quite clear whether the correlation will be a general phenomenon across multiple cancer types.
1 CitationsSource
#1Jie Liao (ZJU: Zhejiang University)H-Index: 3
#2Cui Hao (ZJU: Zhejiang University)H-Index: 2
Last. Xiaohui Fan (ZJU: Zhejiang University)H-Index: 24
view all 8 authors...
Abstract Ethnopharmacological relevance Shenqi Fuzheng (SQ) is a renowned traditional Chinese medicine extracted from Radix Codonopsis and Radix Astragali. Although SQ is widely used to treat myocardial ischemia-reperfusion (I/R) injury, the molecular mechanisms supporting its clinical application remain elusive. Aim of the study The purpose of current study was to understand its cardioprotective effects at the molecular level using network pharmacology approach. Materials and method In an I/R i...
3 CitationsSource
#1Qian Chen (WMU: Wenzhou Medical College)H-Index: 3
#2Ni Ai (ZJU: Zhejiang University)H-Index: 8
Last. Xiaohui Fan (ZJU: Zhejiang University)H-Index: 24
view all 6 authors...
Background Valuable scientific results on biomedicine are very rich, but they are widely scattered in the literature. Topic modeling enables researchers to discover themes from an unstructured collection of documents without any prior annotations or labels. In this paper, taking ginseng as an example, biological dynamic topic model (Bio-DTM) was proposed to conduct a retrospective study and interpret the temporal evolution of the research of ginseng.
6 CitationsSource
#1Zhenhao Li (ZJU: Zhejiang University)H-Index: 3
#2Ting Liu (ZJU: Zhejiang University)H-Index: 2
Last. Yiyu Cheng (ZJU: Zhejiang University)H-Index: 31
view all 6 authors...
In this study, we propose an integrated strategy for the efficient identification and quantification of herbal constituents using liquid chromatography with mass spectrometry. First, liquid chromatography with quadrupole time-of-flight mass spectrometry was employed for the chemical profiling of herbs, where a targeted following non-targeted approach was developed to detect trace constituents by using structural correlations and extracted ion chromatograms. Next, ion pairs and parameters of MS2 ...
3 CitationsSource
#1Yufeng LiuH-Index: 6
#2Ni AiH-Index: 8
Last. Xiaohui FanH-Index: 24
view all 4 authors...
The systemic effects of traditional Chinese medicine (TCM) seem to be a Gordian knot, impossible to untie for decades. With the advent of transcriptomics, a useful sword is provided to cut the knot and shed some light on complex bioprocesses and intrinsic connections among them. Here, we revisit studies on TCM ZHENGs using this approach, highlight its applications on elucidating the potential scientific basis of ZHENG and investigating mechanisms of action for the TCM formula, and demonstrating ...
6 CitationsSource
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