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Vicente Andrés
Ciber
185Publications
43H-index
6,210Citations
Publications 186
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#1Sergio Esteban (Centro Nacional de Investigaciones Cardiovasculares)
#2Cristina Clemente (CSIC: Spanish National Research Council)H-Index: 3
Last.Alicia G. Arroyo (CSIC: Spanish National Research Council)H-Index: 30
view all 13 authors...
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#1Beatriz Dorado (Ciber)H-Index: 4
#2Gro Grunnet Pløen (AU: Aarhus University)
Last.Vicente Andrés (Ciber)H-Index: 43
view all 21 authors...
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder for which no cure exists. The disease is characterized by premature aging and inevitable death in adolescence due to cardiovascular complications. Most HGPS patients carry a heterozygous de novo LMNA c.1824C > T mutation, which provokes the expression of a dominant-negative mutant protein called progerin. Therapies proven effective in HGPS-like mouse models have yielded only modest benefit in HGPS clinical trials. ...
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#1Raquel Toribio-Fernandez (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 1
view all 11 authors...
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#1Ya-Hsuan Ho (University of Cambridge)H-Index: 1
#2Raquel del Toro (Ciber)H-Index: 7
Last.Simón Méndez-Ferrer (University of Cambridge)H-Index: 23
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Summary Hematopoietic stem cells (HSCs) residing in the bone marrow (BM) accumulate during aging but are functionally impaired. However, the role of HSC-intrinsic and -extrinsic aging mechanisms remains debated. Megakaryocytes promote quiescence of neighboring HSCs. Nonetheless, whether megakaryocyte-HSC interactions change during pathological/natural aging is unclear. Premature aging in Hutchinson-Gilford progeria syndrome recapitulates physiological aging features, but whether these arise from...
3 CitationsSource
#1Marian Vila-Caballer (CSIC: Spanish National Research Council)H-Index: 4
Last.Vicente Andrés (Ciber)H-Index: 43
view all 15 authors...
Abstract The CC chemokine 1 (CCL1, also called I-309 or TCA3) is a potent chemoattractant for leukocytes that plays an important role in inflammatory processes and diseases through binding to its receptor CCR8. Here, we investigated the role of the CCL1-CCR8 axis in atherosclerosis. We found increased expression of CCL1 in the aortas of atherosclerosis-prone fat-fed apolipoprotein E (Apoe)-null mice; moreover, in vitro flow chamber assays and in vivo intravital microscopy demonstrated an essenti...
1 CitationsSource
#1Lara del Campo (Ciber)H-Index: 2
#2Amanda Sánchez‐López (Ciber)H-Index: 1
Last.Vicente Andrés (Ciber)H-Index: 43
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Ministerio Ciencia, Innovacion y Universidades, Grant/Award Number: SAF2016-79490-R, SAF2016-8035-P, SEV-2015-0505, SVP-2014-068334; European Regional Development Fund; NIH grants, Grant/Award Number: AG047373, T32-GM008076, F31HL142160; NSF grant, Grant/Award Number: CMMI 1548571; Red de Investigacion Cardiovascular (RETIC Program, Instituto de Salud Carlos III; ProCNIC Foundation
3 CitationsSource
#1Magda R. Hamczyk (University of Oviedo)H-Index: 5
#2Ricardo Villa-Bellosta (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 8
Last.Vicente Andrés (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 43
view all 10 authors...
Abstract Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by progerin, a mutant lamin A variant. HGPS patients display accelerated aging and die prematurely, typically from atherosclerosis complications. Recently, we demonstrated that progerin‐driven vascular smooth muscle cell (VSMC) loss accelerates atherosclerosis leading to premature death in apolipoprotein E‐deficient mice. However, the molecular mechanism underlying this process remains unknown. Using a transcr...
4 CitationsSource
#1Silvia Gonzalez-Ramos (CSIC: Spanish National Research Council)H-Index: 1
#2Marta Paz-García (CSIC: Spanish National Research Council)
Last.Lisardo Boscá (CSIC: Spanish National Research Council)
view all 12 authors...
Atherosclerosis is a chronic disease characterized by vascular lipid retention and inflammation, and pattern recognition receptors (PRRs) are important contributors in early stages of the disease. ...
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#1Magda R. Hamczyk (University of Oviedo)H-Index: 5
#2Vicente Andrés (Ciber)H-Index: 43
ABSTRACTLamin A, a product of the LMNA gene, is an essential nuclear envelope component in most differentiated cells. Mutations in LMNA have been linked to premature aging disorders, including Hutc...
1 CitationsSource
#1Cristina Clemente (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 3
#2Cristina Rius (Ciber)H-Index: 8
Last.Alicia G. Arroyo (CSIC: Spanish National Research Council)H-Index: 30
view all 15 authors...
We thank Angel Colmenar and Laura Balonga for technical support, the BioBanco VIH (Hospital Gregorio Maranon, Madrid) for providing essential reagents, and Simon Bartlett for English editing. This study was supported by grants from the Spanish Ministry of Economy, Industry and Competitiveness (MEIC; RD12/0042/0023 [FEDER cofunded] and SAF2014-52050R and SAF2017-83229R to A.G.A., SAF2015-64287R and SAF2015-71878-REDT to M.R., RD12/0042/0053 [FEDER cofunded] and SAF2015-64767-R to J.M-G., and SAF2...
1 CitationsSource
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