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Vicente Andrés
Centro Nacional de Investigaciones Cardiovasculares
177Publications
41H-index
5,638Citations
Publications 177
Newest
Published on Mar 19, 2019in Cell discovery
Beatriz Dorado3
Estimated H-index: 3
(Ciber),
Beatriz Dorado (Ciber)+ 18 AuthorsGonzález-Gómez C2
Estimated H-index: 2
(Ciber)
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder for which no cure exists. The disease is characterized by premature aging and inevitable death in adolescence due to cardiovascular complications. Most HGPS patients carry a heterozygous de novo LMNA c.1824C > T mutation, which provokes the expression of a dominant-negative mutant protein called progerin. Therapies proven effective in HGPS-like mouse models have yielded only modest benefit in HGPS clinical trials. ...
Published in The Journal of Pathology 5.94
Raquel Toribio-Fernández1
Estimated H-index: 1
(Centro Nacional de Investigaciones Cardiovasculares),
Beatriz Herrero-Fernandez + -3 AuthorsVicente Andrés41
Estimated H-index: 41
(Ciber)
Published on Jul 1, 2019in Cell Stem Cell 21.46
Ya-Hsuan Ho (University of Cambridge), Raquel del Toro (Ciber)+ 17 AuthorsMonika Wittner6
Estimated H-index: 6
(French Institute of Health and Medical Research)
Summary Hematopoietic stem cells (HSCs) residing in the bone marrow (BM) accumulate during aging but are functionally impaired. However, the role of HSC-intrinsic and -extrinsic aging mechanisms remains debated. Megakaryocytes promote quiescence of neighboring HSCs. Nonetheless, whether megakaryocyte-HSC interactions change during pathological/natural aging is unclear. Premature aging in Hutchinson-Gilford progeria syndrome recapitulates physiological aging features, but whether these arise from...
Published on Jul 1, 2019in Journal of Molecular and Cellular Cardiology 5.05
Marian Vila-Caballer4
Estimated H-index: 4
,
José M. González-Granado6
Estimated H-index: 6
+ 12 AuthorsM. J. Sanz39
Estimated H-index: 39
(University of Valencia)
Abstract The CC chemokine 1 (CCL1, also called I-309 or TCA3) is a potent chemoattractant for leukocytes that plays an important role in inflammatory processes and diseases through binding to its receptor CCR8. Here, we investigated the role of the CCL1-CCR8 axis in atherosclerosis. We found increased expression of CCL1 in the aortas of atherosclerosis-prone fat-fed apolipoprotein E ( Apoe )-null mice; moreover, in vitro flow chamber assays and in vivo intravital microscopy demonstrated an essen...
Published on Jun 1, 2019in Aging Cell 7.35
Lara del Campo2
Estimated H-index: 2
(Ciber),
Amanda Sánchez‐López1
Estimated H-index: 1
(Ciber)
+ 10 AuthorsJesus Maria Ruiz Cabello Osuna32
Estimated H-index: 32
(Ciber)
Ministerio Ciencia, Innovacion y Universidades, Grant/Award Number: SAF2016-79490-R, SAF2016-8035-P, SEV-2015-0505, SVP-2014-068334; European Regional Development Fund; NIH grants, Grant/Award Number: AG047373, T32-GM008076, F31HL142160; NSF grant, Grant/Award Number: CMMI 1548571; Red de Investigacion Cardiovascular (RETIC Program, Instituto de Salud Carlos III; ProCNIC Foundation
Published on Apr 1, 2019in Embo Molecular Medicine 10.62
Magda R. Hamczyk5
Estimated H-index: 5
(University of Oviedo),
Magda R Hamczyk1
Estimated H-index: 1
(University of Oviedo)
+ 7 AuthorsCarlos López-Otín110
Estimated H-index: 110
(University of Oviedo)
Abstract Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by progerin, a mutant lamin A variant. HGPS patients display accelerated aging and die prematurely, typically from atherosclerosis complications. Recently, we demonstrated that progerin‐driven vascular smooth muscle cell (VSMC) loss accelerates atherosclerosis leading to premature death in apolipoprotein E‐deficient mice. However, the molecular mechanism underlying this process remains unknown. Using a transcr...
Published on Mar 1, 2019in The FASEB Journal 5.39
Silvia González-Ramos1
Estimated H-index: 1
(CSIC: Spanish National Research Council),
Marta Paz-García (CSIC: Spanish National Research Council)+ 9 AuthorsPaloma Martín-Sanz (CSIC: Spanish National Research Council)
Atherosclerosis is a chronic disease characterized by vascular lipid retention and inflammation, and pattern recognition receptors (PRRs) are important contributors in early stages of the disease. Given the implication of the intracellular PRR nucleotide-binding oligomerization domain 1 (NOD1) in cardiovascular diseases, we investigated its contribution to early atherosclerosis. We evidenced NOD1 induction in atherosclerotic human and mouse tissues, predominantly in vascular endothelial cells. A...
Published on Jan 1, 2019in Nucleus 2.16
Magda R. Hamczyk5
Estimated H-index: 5
(University of Oviedo),
Vicente Andrés41
Estimated H-index: 41
(Ciber)
ABSTRACTLamin A, a product of the LMNA gene, is an essential nuclear envelope component in most differentiated cells. Mutations in LMNA have been linked to premature aging disorders, including Hutchinson-Gilford progeria syndrome (HGPS). HGPS is caused by progerin, an aberrant form of lamin A that leads to premature death, typically from the complications of atherosclerotic disease. A key characteristic of HGPS is a severe loss of vascular smooth muscle cells (VSMCs) in the arteries. Various mou...
Published on Dec 1, 2018in Nature Communications 11.88
Cristina Clemente3
Estimated H-index: 3
(Centro Nacional de Investigaciones Cardiovasculares),
Cristina Rius8
Estimated H-index: 8
(Ciber)
+ 12 AuthorsCristina Rodríguez27
Estimated H-index: 27
(Ciber)
Matrix metalloproteinases are involved in vascular remodeling. Little is known about their immune regulatory role in atherosclerosis. Here we show that mice deficient for MT4-MMP have increased adherence of macrophages to inflamed peritonea, and larger lipid deposits and macrophage burden in atherosclerotic plaques. We also demonstrate that MT4-MMP deficiency results in higher numbers of patrolling monocytes crawling and adhered to inflamed endothelia, and the accumulation of Mafb+ apoptosis inh...
Published on Nov 1, 2018in Atherosclerosis 4.25
A. Purroy3
Estimated H-index: 3
(University of Navarra),
Carmen Roncal17
Estimated H-index: 17
(University of Navarra)
+ 8 AuthorsJosé A. Páramo36
Estimated H-index: 36
(University of Navarra)
Abstract Background and aims Matrix metalloproteinases (MMPs) have been implicated in atherosclerosis and vascular calcification. Among them, we reported that MMP10 is present in human atheroma, associated with atherosclerosis. However, it remains unclear whether MMP10 is involved in atherogenesis and vascular calcification. Methods MMP10 was measured in serum from patients with subclinical atherosclerosis and analyzed in carotid endarterectomies by immunostaining. ApoE-deficient mice ( Apoe −/−...
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