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Jilly Naaijen
Radboud University Nijmegen
PsychologyNeuroscienceAnterior cingulate cortexAttention deficit hyperactivity disorderGlutamate receptor
29Publications
6H-index
150Citations
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Publications 33
Newest
#1Christienne G. Damatac (Radboud University Nijmegen)H-Index: 3
#2Marcel P. Zwiers (Radboud University Nijmegen)H-Index: 38
Last. Emma Sprooten (Radboud University Nijmegen)H-Index: 27
view all 13 authors...
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by age-inappropriate levels of inattention and/or hyperactivity-impulsivity. ADHD has been related to differences in white matter microstructure, measured by diffusion-weighted imaging (DWI) and quantified by fractional anisotropy (FA). In the largest DWI analysis of ADHD to date, we systematically investigated if FA is associated with: current and lifetime diagnosis, categorical diagnosis and continuo...
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#1Lara M. Wierenga (LEI: Leiden University)H-Index: 4
#2Gaelle E. Doucet (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 17
Last. Ole A. Andreassen (University of Oslo)H-Index: 89
view all 160 authors...
For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy indivi...
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#2Sarita DamH-Index: 1
Last. Alejandro Arias VasquezH-Index: 24
view all 10 authors...
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. Given the growing evidence of gut microbiota being involved in psychiatric (including neurodevelopmental) disorders, we aimed to identify differences in gut microbiota composition between participants with ADHD and controls and to investigate the role of the microbiota in inattention and hyperactivity/impulsivity. Fecal samples were collected from 107 participants (NADHD = 42; Ncontrols = 50; NsubthreholdADH...
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#1Milou Straathof (UU: Utrecht University)H-Index: 2
#2Erwin L. A. Blezer (UU: Utrecht University)H-Index: 27
Last. Maarten Mennes (Radboud University Nijmegen)H-Index: 35
view all 65 authors...
Abstract Obsessive-compulsive disorder (OCD) is increasingly considered to be a neurodevelopmental disorder. However, despite insights in neural substrates of OCD in adults, less is known about mechanisms underlying compulsivity during brain development in children and adolescents. Therefore, we developed an adolescent rat model of compulsive checking behavior and investigated developmental changes in structural and functional measures in the frontostriatal circuitry. Five-weeks old Sprague Dawl...
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#1Thaira J.C. Openneer (UMCG: University Medical Center Groningen)H-Index: 5
#2Natalie J. Forde (Radboud University Nijmegen)H-Index: 5
Last. Andrea Dietrich (UMCG: University Medical Center Groningen)H-Index: 15
view all 7 authors...
Abstract Findings of executive functioning deficits in Tourette syndrome (TS) have so far been inconsistent, possibly due to methodological challenges of previous studies, such as the use of small sample sizes and not accounting for comorbid attention-deficit/hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), or medication use. We aimed to address these issues by examining several areas of executive functioning (response inhibition, attentional flexibility, cognitive control, an...
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#1Thaira J.C. Openneer (UMCG: University Medical Center Groningen)H-Index: 5
#2Jan-Bernard C. Marsman (UMCG: University Medical Center Groningen)H-Index: 10
Last. Pieter J. Hoekstra (UMCG: University Medical Center Groningen)H-Index: 40
view all 9 authors...
Abstract Little is known about the brain’s functional organization during resting-state in children with Tourette syndrome (TS). We aimed to investigate this with a specific focus on the role of comorbid attention-deficit/hyperactivity disorder (ADHD). We applied graph theoretical analysis to resting-state functional magnetic resonance imaging data of 109 8-to-12-year-old children with TS (n=46), ADHD without tics (n=23), and healthy controls (n=40). First, we compared these three groups, and in...
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#1Michael C. Craig ('KCL': King's College London)H-Index: 29
#2Leandra M Mulder (Radboud University Nijmegen)H-Index: 1
Last. Jilly Naaijen (Radboud University Nijmegen)H-Index: 6
view all 23 authors...
Abstract Disruptive behavior is associated with societally and personally problematic levels of aggression and has been linked to abnormal structure and function of fronto-amygdala-striatal regions. Abnormal glutamatergic signalling within this network may play a role in aggression. However, disruptive behavior does not represent a homogeneous construct, but can be fractionated across several dimensions. Of particular interest, callous-unemotional (CU) traits have been shown to modulate the seve...
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#1Sophie E.A. Akkermans (Radboud University Nijmegen)H-Index: 4
#2Daan van Rooij (Radboud University Nijmegen)H-Index: 12
Last. Jan K. Buitelaar (Radboud University Nijmegen)H-Index: 104
view all 9 authors...
Abstract Attention-deficit/hyperactivity disorder (ADHD) is the most common comorbidity in individuals with Tourette syndrome (TS). Yet, it is unclear to what extent TS and ADHD show overlapping or distinct neural abnormalities. ADHD has been associated with altered reward processing, but there are very few studies on reward processing in TS. This study assessed neural activation of basal ganglia and thalamus during reward anticipation and receipt in children with TS and/or ADHD. We analysed mea...
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#1Renata B. Cupertino (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 5
Last. Emma Sprooten (Radboud University Nijmegen)H-Index: 27
view all 20 authors...
Neuroimaging studies have associated Attention-Deficit/Hyperactivity Disorder (ADHD) with altered brain anatomy. However, small and heterogeneous study samples, and the use of region-of-interest and tissue-specific analyses have limited the consistency and replicability of these effects. The present study uses a fully data-driven multivariate approach to investigate alterations in both gray and white matter simultaneously, and capture neuroanatomical features associated with ADHD in two large, i...
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#1Llera Arenas (Radboud University Nijmegen)
Last. Mennes
view all 6 authors...
Functional connectivity between brain regions is modulated by cognitive states or experimental conditions. Such connectivity variations can be appreciated in covariance or correlation matrices obtained from fMRI data. A multivariate methodology that can capture fMRI connectivity maps in light of different experimental conditions would be of primary importance to learn about the specific roles of the different brain areas involved in the observed connectivity variations. Here we introduce Spatial...
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